Author Archives: Gregory

A novel signal sequence negative multimeric glycosomal protein required for cell cycle progression of Leishmania donovani parasites.

Expression of the intracellular type amastigote particular genes within the Leishmania donovani parasite performs a serious position in parasite replication within the macrophage. Within the present work, we’ve characterised a… Read more »

Multimeric Amphipathic α-Helical Sequences for Rapid and Efficient Intracellular Protein Transport at Nanomolar Concentrations.

An amphipathic leucine (L) and lysine (Ok)-rich α-helical peptide is multimerized primarily based on helix-loop-helix buildings to maximise the penetrating actions. The multimeric LK-based cell penetrating peptides (LK-CPPs) can penetrate… Read more »

Structure-Function Relationship of Inclusion Bodies of a Multimeric Protein

Excessive stage expression of recombinant proteins in micro organism typically leads to their aggregation into inclusion our bodies. Formation of inclusion our bodies poses a significant bottleneck in high-throughput restoration… Read more »

n-Layer BET adsorption isotherm modeling for multimeric Protein A ligand and its lifetime determination

Langmuir and different single-layer adsorption isotherms present the binding conduct of pure Protein A ligands immobilized on a column. Nevertheless, no fashions have been proven in literature to elucidate the… Read more »

Protein misfolded oligomers from cell membranes and abrogates their cytotoxicity

Trodusquemine displaces protein misfolded oligomers from cell membranes and abrogates their cytotoxicity through a generic mechanism   The onset and progression of numerous protein misfolding diseases are associated with the presence of… Read more »

Potein Separation based on charge anisotropy by spherical polyelectrolyte brushes

Selective protein separation based mostly on cost anisotropy by spherical polyelectrolyte brushes   Protein purification is of significant significance within the meals business, drug discovery and different associated fields. Amongst many separation… Read more »

Fragment Screening for 14 Different Biologically Active RNAs and 10 DNA and protein counter-screens

19F-NMR-based fragment screening for 14 completely different biologically lively RNAs and 10 DNA and protein counter-screens   We report right here on the nuclear magnetic resonance (NMR) 19 F screening of 14… Read more »