
Trodusquemine displaces protein misfolded oligomers from cell membranes and abrogates their cytotoxicity through a generic mechanism
The onset and progression of numerous protein misfolding diseases are associated with the presence of oligomers formed during the aberrant aggregation of several different proteins, including amyloid-β (Aβ) in Alzheimer’s disease and α-synuclein (αS) in Parkinson’s disease.
These small, soluble aggregates are currently major targets for drug discovery. In this study, we show that trodusquemine, a naturally-occurring aminosterol, markedly reduces the cytotoxicity of αS, Aβ and HypF-N oligomers to human neuroblastoma cells by displacing the oligomers from cell membranes in the absence of any substantial morphological and structural changes to the oligomers.
These results indicate that the reduced toxicity results from a mechanism that is common to oligomers from different proteins, shed light on the origin of the toxicity of the most deleterious species associated with protein aggregation and suggest that aminosterols have the therapeutically-relevant potential to protect cells from the oligomer-induced cytotoxicity associated with numerous protein misfolding diseases.
Comparing supermarket loyalty card data with traditional diet survey data for understanding how protein is purchased and consumed in older adults for the UK, 2014-16
Background: Our ability to understand population-level dietary intake patterns is dependent on having access to high quality data. Diet surveys are common diet assessment methods, but can be limited by bias associated with under-reporting.
Food purchases tracked using supermarket loyalty card records may supplement traditional surveys, however they are rarely available to academics and policy makers. The aim of our study is to explore population level patterns of protein purchasing and consumption in ageing adults (40 years onwards).
Methods: We used diet survey data from the National Diet and Nutrition Survey (2014-16) on food consumption, and loyalty card records on food purchases from a major high street supermarket retailer (2016-17) covering the UK. We computed the percentage of total energy derived from protein, protein intake per kg of body mass, and percentage of protein acquired by food type.
Results: We found that protein consumption (as the percentage of total energy purchased) increased between ages 40-65 years, and declined thereafter. In comparison, protein purchased in supermarkets was roughly 2-2.5 percentage points lower at each year of age.
The proportion of adults meeting recommended levels of protein was lowest in age groups 55-69 and 70+. The time of protein consumption was skewed towards evening meals, with low intakes during breakfast or between main meals. Meat, fish and poultry dominated as sources of protein purchased and consumed, although adults also acquired a large share of their protein from dairy and bread, with little from plant protein.
Conclusions: Our study provides novel insights into how protein is purchased and consumed by ageing adults in the UK. Supermarket loyalty card data can reveal patterns of protein purchasing that when combined with traditional sources of dietary intake may enhance our understanding of dietary behaviors.
Keywords: Big data; Diet surveys; Population; Protein; Supermarket loyalty cards.

choleratox
Recombinant EBV EBNA1 Mosaic Protein, His, E.coli-100ug |
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QP11732-100ug | EnQuireBio | 100ug | EUR 261.6 |
Recombinant EBV EBNA1 Mosaic Protein, His, E.coli-500ug |
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QP11732-500ug | EnQuireBio | 500ug | EUR 795.6 |
Recombinant EBV EBNA1 Mosaic Protein (aa 1-90 & 408-498) [GST] |
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VAng-Lsx0111-100g | Creative Biolabs | 100 µg | EUR 759.6 |
Description: EBV EBNA1 Mosaic protein [GST], recombinant protein from E. coli. |
Recombinant EBV EBNA1 Mosaic Protein (aa 1-90 & 408-498) [GST] |
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VAng-Lsx0111-500g | Creative Biolabs | 500 µg | EUR 2419.2 |
Description: EBV EBNA1 Mosaic protein [GST], recombinant protein from E. coli. |
Recombinant EBV EBNA1 Mosaic Protein (aa 1-90 & 408-498) [His] |
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VAng-2528Lsx-100g | Creative Biolabs | 100 µg | EUR 555.6 |
Description: EBV EBNA1 Mosaic protein, His tag at C-terminus, recombinant protein from E. coli. |
Recombinant EBV EBNA1 Mosaic Protein (aa 1-90 & 408-498) [His] |
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VAng-2528Lsx-1mg | Creative Biolabs | 1 mg | EUR 3360 |
Description: EBV EBNA1 Mosaic protein, His tag at C-terminus, recombinant protein from E. coli. |
Recombinant EBV EBNA1 Mosaic Protein (aa 1-90 & 408-498) [His] |
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VAng-2528Lsx-500g | Creative Biolabs | 500 µg | EUR 2040 |
Description: EBV EBNA1 Mosaic protein, His tag at C-terminus, recombinant protein from E. coli. |
EBNA1 protein |
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30-1925 | Fitzgerald | 500 ug | EUR 678 |
Description: Purified Recombinant EBNA1 protein |
EBV EBNA protein |
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30-AE46 | Fitzgerald | 200 ug | EUR 900 |
Description: Purified recombinant EBV EBNA protein |
EBNA1 protein (His tag) |
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80-1340 | Fitzgerald | 100 ug | EUR 289.2 |
Description: Purified recombinant EBNA1 protein (His tag) |
Recombinant EBNA1 Protein [GST] |
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VAng-Lsx0122-100g | Creative Biolabs | 100 µg | EUR 818.4 |
Description: EBNA1 (EBV) (P03211) partial recombinant protein with GST tag expressed in E. coli. |
EBNA1 Binding Protein 2 Protein |
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20-abx260778 | Abbexa |
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EBNA1 Binding Protein 2 (EBNA1BP2) Antibody |
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abx026949-400ul | Abbexa | 400 ul | EUR 627.6 |
EBNA1 Binding Protein 2 (EBNA1BP2) Antibody |
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abx026949-80l | Abbexa | 80 µl | EUR 343.2 |
EBNA1 Binding Protein 2 (EBNA1BP2) Antibody |
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20-abx123650 | Abbexa |
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EBNA1BP2 EBNA1 Binding Protein 2 Human Recombinant Protein |
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PROTQ99848 | BosterBio | Regular: 20ug | EUR 380.4 |
Description: Recombinant Human EBNA1BP2 produced in E. coli is a single polypeptide chain containing 329 amino acids (1-306) and having a molecular mass of 37.2kDa.;EBNA1BP2 is fused to a 23 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques. |
Recombinant EBNA1 Protein [His] (1.185 mg/mL) |
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VAng-0610Lsx-inquire | Creative Biolabs | inquire | Ask for price |
Description: Epstein-Barr Virus (EBV) Nuclear Antigen-1 (EBNA-1), recombinant protein from E. coli. MW 63 kDa, 1.185 mg/mL. |
Recombinant EBNA1 Protein [His] (1.25 mg/mL) |
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VAng-0611Lsx-inquire | Creative Biolabs | inquire | Ask for price |
Description: Epstein-Barr Virus (EBV) Nuclear Antigen-1 (EBNA-1), recombinant protein from E. coli. MW 63 kDa, 1.25 mg/mL. |
Recombinant (E.Coli, GST tag) Epstein-Barr Virus (EBV/HHV-4) Mosaic EBNA1 |
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RP-347 | Alpha Diagnostics | 100 ug | EUR 343.2 |
Epstein-Barr Virus (HHV-4) EBNA1 Protein |
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20-abx260340 | Abbexa |
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Mouse EBNA1 Binding Protein 2 (EBNA1BP2) ELISA Kit |
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abx389130-96tests | Abbexa | 96 tests | EUR 1093.2 |
Human EBNA1 Binding Protein 2 (EBNA1BP2) ELISA Kit |
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abx384822-96tests | Abbexa | 96 tests | EUR 1093.2 |
Recombinant EBNA1 Protein (aa 1-90, 408-498) [GST] |
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VAng-Lsx0128-inquire | Creative Biolabs | inquire | Ask for price |
Description: EBV NA1 (aa 1-90, 408-498) [GST], recombinant protein from E. coli. |
pCXWB- EBNA1 |
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PVT10196 | Lifescience Market | 2 ug | EUR 361.2 |
Epstein-Barr Virus (HHV-4) Mosaic EBNA1 Protein |
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20-abx260113 | Abbexa |
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EBV EBNA-1 IgG ELISA Kit |
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DEIA332 | Creative Diagnostics | 96T | EUR 618 |
Description: The EBVEBNA-1 IgG Antibody ELISA Test Kit has been designed for the the detectionand the quantitative determination of specific IgG antibodies against EBVEBNA-1 in serum and plasma. |
EBV EBNA-1 IgA ELISA Kit |
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DEIA333 | Creative Diagnostics | 96T | EUR 618 |
Description: The EBVEBNA-1 IgA Antibody ELISA Test Kit has been designed for the the detectionand the quantitative determination of specific IgA antibodies against EBVEBNA-1 in serum and plasma. |
EBV EBNA-1 IgM ELISA Kit |
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DEIA334 | Creative Diagnostics | 96T | EUR 618 |
Description: The EBVEBNA-1 IgM Antibody ELISA Test Kit has been designed for the the detectionand the quantitative determination of specific IgM antibodies against EBVEBNA-1 in serum and plasma. |
Epstein-Barr Virus (EBV) Epstein-Bar Nuclear Antigen-1 (EBNA-1) Protein |
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abx061529-1mg | Abbexa | 1 mg | EUR 2030.4 |
pCXWB- EBNA1 Plasmid |
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PVT7175 | Lifescience Market | 2 ug | EUR 319.2 |
EBV antigen EBNA-1 Antibody |
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abx140258-01mg | Abbexa | 0.1 mg | EUR 393.6 |
EBNA1 (RFP-Bsd) Lentivirus |
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LVP1134-RB | GenTarget | 1x107 IFU/ml x 200ul | EUR 418.8 |
Description: Premade lentivirus expressing Epstein Barr Virus' EBNA1 gene under EF1a promoter, containing RFP-Blasticidin dual marker. |
EBNA1 (GFP-Puro) Lentivirus |
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LVP1134-GP | GenTarget | 1x107 IFU/ml x 200ul | EUR 418.8 |
Description: Premade lentivirus expressing Epstein Barr Virus' EBNA1 gene under EF1a promoter, containing GFP-Puromycin dual marker. |
EBNA1 (RFP-Bsd) Lentivirus in PBS |
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LVP1134-RB-PBS | GenTarget | 1x107 IFU/ml x 200ul | EUR 852 |
Description: Concentrated lentivirus in PBS expressing Epstein Barr Virus' EBNA1 gene under EF1a promoter, containing RFP-Blasticidin dual marker. |
EBNA1 (GFP-Puro) Lentivirus in PBS |
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LVP1134-GP-PBS | GenTarget | 1x107 IFU/ml x 200ul | EUR 852 |
Description: Concentrated lentivirus in PBS expressing Epstein Barr Virus' EBNA1 gene under EF1a promoter, containing GFP-Puromycin dual marker. |
HHV-4 recombinant mosaic EBNA1 antigen |
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00212-V-01mg | Virogen | 0,1 mg | EUR 321 |
Description: HHV-4 recombinant mosaic EBNA1 antigen. Region: 1-90/408-498aa |
HHV-4 recombinant mosaic EBNA1 antigen |
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00212-V-1000ug | Virogen | 1000 ug | EUR 1539 |
Description: HHV-4 recombinant mosaic EBNA1 antigen. Region: 1-90/408-498aa |
Recombinant Epstein-Barr Virus (HHV-4) Mosaic EBNA1 |
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7-07786 | CHI Scientific | 100µg | Ask for price |
Recombinant Epstein-Barr Virus (HHV-4) Mosaic EBNA1 |
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7-07787 | CHI Scientific | 500µg | Ask for price |
Recombinant Epstein-Barr Virus (HHV-4) Mosaic EBNA1 |
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7-07788 | CHI Scientific | 1000µg | Ask for price |
Epstein-Barr Virus Nuclear Antigen 1 (EBNA1) Antibody |
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abx414510-01mg | Abbexa | 0.1 mg | EUR 526.8 |
Custom Testing of Samples for Antibodies (IgA/IgG/IgM) to Epstein Barr Virus (EBV/HHV-4) proteins (EBNA-1/EA/VCA/ED) by ELISA |
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510-200-CUX | Alpha Diagnostics | Custom | Ask for price |
Recombinant Epstein-Barr Virus (HHV-4) EBNA1, His Tag |
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7-07789 | CHI Scientific | 100µg | Ask for price |
Recombinant Epstein-Barr Virus (HHV-4) EBNA1, His Tag |
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7-07790 | CHI Scientific | 500µg | Ask for price |
Recombinant Epstein-Barr Virus (HHV-4) EBNA1, His Tag |
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7-07791 | CHI Scientific | 1000µg | Ask for price |
Epstein-Barr virus Epstein-Barr nuclear antigen 1 (EBNA1) |
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1-CSB-EP365878EFA | Cusabio |
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Description: Recombinant Epstein-Barr virus Epstein-Barr nuclear antigen 1(EBNA1),partial expressed in E.coli |
HHV-4 recombinant mosaic EBNA1 antigen. Region: 1-90/408-498aa |
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00212-V-100ugvial | Virogen | 100ug/vial | EUR 150 |
Description: HHV-4 recombinant mosaic EBNA1 antigen. Region: 1-90/408-498aa |
Goat Anti-EBV EBNA-1 Polyclonal antibody [HRP] |
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CABT-RM208 | Creative Diagnostics | 1 ml | EUR 982.8 |
Human Epstein-Barr virus nuclear antigen (EBNA1) antibody (IgG) ELISA kit |
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CSB-EQ027763HU-24T | Cusabio | 1 plate of 24 wells | EUR 198 |
Description: Qualitativeindirect ELISA kit for measuring Human Epstein-Barr virus nuclear antigen (EBNA1) antibody (IgG) in samples from serum. A new trial version of the kit, which allows you to test the kit in your application at a reasonable price. |
Human Epstein-Barr virus nuclear antigen (EBNA1) antibody (IgG) ELISA kit |
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1-CSB-EQ027763HU | Cusabio |
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Description: Qualitativeindirect ELISA kit for measuring Human Epstein-Barr virus nuclear antigen (EBNA1) antibody (IgG) in samples from serum. Now available in a cost efficient pack of 5 plates of 96 wells each, conveniently packed along with the other reagents in 5 separate kits. |
EBNA1BP2 protein (His tag) |
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80R-3035 | Fitzgerald | 100 ug | EUR 392.4 |
Description: Purified recombinant EBNA1BP2 protein (His tag) |
EBNA protein |
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30-AE47 | Fitzgerald | 1 mg | EUR 486 |
Description: Purified native EBNA protein |
EBV protein |
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30-1275 | Fitzgerald | 1 mg | EUR 4177.2 |
Description: Purified recombinant EBV protein |
EBV protein |
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30-1276 | Fitzgerald | 1 mg | EUR 4177.2 |
Description: Purified recombinant EBV protein |
EBV Protein |
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abx069822-1ml | Abbexa | 1 ml | EUR 828 |
EBV Protein |
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abx069824-1mg | Abbexa | 1 mg | EUR 1762.8 |
EBV Protein |
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abx069825-1ml | Abbexa | 1 ml | EUR 376.8 |
EBV Protein |
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abx069828-1mg | Abbexa | 1 mg | EUR 2180.4 |
EBV Protein |
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abx069829-1mg | Abbexa | 1 mg | EUR 2131.2 |
Human Anti-Epstein Barr Virus (EBV/HHV-4) Nuclear Antigen 1 (EBNA-1) IgA ELISA Kit, 96 tests, quantitative |
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510-200-HEA | Alpha Diagnostics | 1 Kit | EUR 708 |
Human Anti-Epstein Barr Virus (EBV/HHV-4) Nuclear Antigen 1 (EBNA-1) IgG ELISA Kit, 96 tests, quantitative |
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510-205-HEG | Alpha Diagnostics | 1 Kit | EUR 708 |
Human Anti-Epstein Barr Virus (EBV/HHV-4) Nuclear Antigen 1 (EBNA-1) IgM ELISA Kit, 96 tests, quantitative |
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510-210-HEM | Alpha Diagnostics | 1 Kit | EUR 708 |
Anti-EBV-EBNA1 antibody |
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STJ16101052 | St John's Laboratory | 100 µg | EUR 424.8 |
EBNA1BP2 Recombinant Protein (Rat) |
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RP198986 | ABM | 100 ug | Ask for price |
EBNA1BP2 Recombinant Protein (Human) |
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RP010111 | ABM | 100 ug | Ask for price |
EBNA1BP2 Recombinant Protein (Mouse) |
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RP130700 | ABM | 100 ug | Ask for price |
EBNA1BP2 Protein Vector (Rat) (pPM-C-HA) |
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PV265320 | ABM | 500 ng | EUR 723.6 |
EBNA1BP2 Protein Vector (Rat) (pPB-C-His) |
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PV265318 | ABM | 500 ng | EUR 723.6 |
EBNA1BP2 Protein Vector (Rat) (pPB-N-His) |
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PV265319 | ABM | 500 ng | EUR 723.6 |
EBNA1BP2 Protein Vector (Rat) (pPM-C-His) |
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PV265321 | ABM | 500 ng | EUR 723.6 |
EBNA1BP2 Protein Vector (Human) (pPM-C-HA) |
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PV013483 | ABM | 500 ng | EUR 394.8 |
EBNA1BP2 Protein Vector (Mouse) (pPM-C-HA) |
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PV174272 | ABM | 500 ng | EUR 723.6 |
EBNA1BP2 Protein Vector (Human) (pPB-C-His) |
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PV013481 | ABM | 500 ng | EUR 394.8 |
EBNA1BP2 Protein Vector (Human) (pPB-N-His) |
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PV013482 | ABM | 500 ng | EUR 394.8 |
EBNA1BP2 Protein Vector (Human) (pPM-C-His) |
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PV013484 | ABM | 500 ng | EUR 394.8 |
EBNA1BP2 Protein Vector (Mouse) (pPB-C-His) |
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PV174270 | ABM | 500 ng | EUR 723.6 |
EBNA1BP2 Protein Vector (Mouse) (pPB-N-His) |
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PV174271 | ABM | 500 ng | EUR 723.6 |
EBNA1BP2 Protein Vector (Mouse) (pPM-C-His) |
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PV174273 | ABM | 500 ng | EUR 723.6 |
EBV EA protein |
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30R-AE005 | Fitzgerald | 100 ug | EUR 392.4 |
Description: Purified recombinant EBV EA protein |
EBV EA protein |
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30-1280 | Fitzgerald | 1 mg | EUR 4177.2 |
Description: Purified recombinant EBV EA protein |
EBV EA protein |
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30-1920 | Fitzgerald | 1 ml | EUR 496.8 |
Description: Viral lysate containing a high concentration of EBV antigens, including VCA, EBNA, EA-D and EA-R |
The role of monoamine oxidase A in HPV-16 E7-induced epithelial-mesenchymal transition and HIF-1α protein accumulation in non-small cell lung cancer cells
Our previous studies have found that human papillomavirus (HPV)-16 E7 oncoprotein promotes epithelial-mesenchymal transition (EMT) and hypoxia-inducible factor-1α (HIF-1α) protein accumulation in non-small cell lung cancer (NSCLC) cells and monoamine oxidase A (MAOA) is highly expressed in NSCLC tissues.
Here, we further explored the role of MAOA in HPV-16 E7-induced EMT and HIF-1α protein accumulation in A549 and NCI-H460 NSCLC cells. Our results showed that HPV-16 E7 enhanced MAOA expression in NSCLC cells. Additionally, MAOA knockout inhibited HPV-16 E7-induced migration, invasion, and EMT, and significantly reduced HPV-16 E7-induced ROS generation and HIF-1α protein accumulation via promoting its degradation.
Furthermore, MAOA knockout suppressed HPV-16 E7-induced ERK1/2 activation. In vivo, MAOA knockout inhibited tumor growth, metastasis, and the expression of EMT-related markers and HIF-1α proteins induced by HPV-16 E7 in NCI-H460 NSCLC subcutaneous xenograft and in situ intrapulmonary models of nude mice. Taken together, our findings provide evidence that MAOA plays a key role in EMT and HIF-1α protein accumulation induced by HPV-16 E7 in NSCLC cells, suggesting that MAOA may be a potential therapeutic target for HPV-related NSCLC.
PKN1 Conjugated Antibody |
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C48392 | SAB | 100ul | EUR 476.4 |
PKN1 Polyclonal Antibody |
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ABP59926-003ml | Abbkine | 0.03ml | EUR 189.6 |
Description: A polyclonal antibody for detection of PKN1 from Human, Mouse, Rat. This PKN1 antibody is for WB, ELISA. It is affinity-purified from rabbit serum by affinity-chromatography using the specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from part region of human PKN1 protein at amino acid sequence of 720-800 |
PKN1 Polyclonal Antibody |
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ABP59926-01ml | Abbkine | 0.1ml | EUR 346.8 |
Description: A polyclonal antibody for detection of PKN1 from Human, Mouse, Rat. This PKN1 antibody is for WB, ELISA. It is affinity-purified from rabbit serum by affinity-chromatography using the specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from part region of human PKN1 protein at amino acid sequence of 720-800 |
PKN1 Polyclonal Antibody |
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ABP59926-02ml | Abbkine | 0.2ml | EUR 496.8 |
Description: A polyclonal antibody for detection of PKN1 from Human, Mouse, Rat. This PKN1 antibody is for WB, ELISA. It is affinity-purified from rabbit serum by affinity-chromatography using the specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from part region of human PKN1 protein at amino acid sequence of 720-800 |
PKN1 Polyclonal Antibody |
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ES8989-100ul | ELK Biotech | 100ul | EUR 334.8 |
Description: A Rabbit Polyclonal antibody against PKN1 from Human/Mouse/Rat. This antibody is tested and validated for WB, ELISA, WB, ELISA |
PKN1 Polyclonal Antibody |
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ES8989-50ul | ELK Biotech | 50ul | EUR 248.4 |
Description: A Rabbit Polyclonal antibody against PKN1 from Human/Mouse/Rat. This antibody is tested and validated for WB, ELISA, WB, ELISA |
PKN1 Antibody (C-Terminal) |
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F53997-0.05ML | NSJ Bioreagents | 0.05 ml | EUR 140.25 |
Description: PKC-related serine/threonine-protein kinase involved in various processes such as regulation of the intermediate filaments of the actin cytoskeleton, cell migration, tumor cell invasion and transcription regulation. Regulates the cytoskeletal network by phosphorylating proteins such as VIM and neurofilament proteins NEFH, NEFL and NEFM, leading to inhibit their polymerization. Phosphorylates 'Ser-575', 'Ser-637' and 'Ser-669' of MAPT/Tau, lowering its ability to bind to microtubules, resulting in disruption of tubulin assembly. Acts as a key coactivator of androgen receptor (ANDR)-dependent transcription, by being recruited to ANDR target genes and specifically mediating phosphorylation of 'Thr-11' of histone H3 (H3T11ph), a specific tag for epigenetic transcriptional activation that promotes demethylation of histone H3 'Lys-9' (H3K9me) by KDM4C/JMJD2C. Phosphorylates HDAC5, HDAC7 and HDAC9, leading to impair their import in the nucleus. Phosphorylates 'Thr-38' of PPP1R14A, 'Ser- 159', 'Ser-163' and 'Ser-170' of MARCKS, and GFAP. Able to phosphorylate RPS6 in vitro. |
PKN1 Antibody (C-Terminal) |
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F53997-0.2ML | NSJ Bioreagents | 0.2 ml | EUR 322.15 |
Description: PKC-related serine/threonine-protein kinase involved in various processes such as regulation of the intermediate filaments of the actin cytoskeleton, cell migration, tumor cell invasion and transcription regulation. Regulates the cytoskeletal network by phosphorylating proteins such as VIM and neurofilament proteins NEFH, NEFL and NEFM, leading to inhibit their polymerization. Phosphorylates 'Ser-575', 'Ser-637' and 'Ser-669' of MAPT/Tau, lowering its ability to bind to microtubules, resulting in disruption of tubulin assembly. Acts as a key coactivator of androgen receptor (ANDR)-dependent transcription, by being recruited to ANDR target genes and specifically mediating phosphorylation of 'Thr-11' of histone H3 (H3T11ph), a specific tag for epigenetic transcriptional activation that promotes demethylation of histone H3 'Lys-9' (H3K9me) by KDM4C/JMJD2C. Phosphorylates HDAC5, HDAC7 and HDAC9, leading to impair their import in the nucleus. Phosphorylates 'Thr-38' of PPP1R14A, 'Ser- 159', 'Ser-163' and 'Ser-170' of MARCKS, and GFAP. Able to phosphorylate RPS6 in vitro. |
PKN1 Antibody (C-Terminal) |
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F53997-005ML | NSJ Bioreagents | 0.05 ml | EUR 165 |
PKN1/PRK1 Conjugated Antibody |
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C35295 | SAB | 100ul | EUR 476.4 |
Protein Kinase N1 (PKN1) Antibody |
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20-abx135704 | Abbexa |
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Protein Kinase N1 (PKN1) Antibody |
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20-abx101658 | Abbexa |
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Protein Kinase N1 (PKN1) Antibody |
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20-abx174267 | Abbexa |
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Protein Kinase N1 (PKN1) Antibody |
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20-abx008827 | Abbexa |
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Monoclonal PKN1 Antibody, Clone: 4H10B1 |
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AMM03009G | Leading Biology | 0.1ml | EUR 633.6 |
Description: A Monoclonal antibody against Human PKN1. The antibodies are raised in Mouse and are from clone 4H10B1. This antibody is applicable in WB and IHC, FC, ICC, E |
Monoclonal PKN1 Antibody, Clone: EPR3238 |
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AMM07214G | Leading Biology | 0.1ml | EUR 633.6 |
Description: A Monoclonal antibody against Human PKN1. The antibodies are raised in Rabbit and are from clone EPR3238. This antibody is applicable in WB, FC |
Antibody for Human PKN1 (pThr774) |
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SPC-1065D | Stressmarq | 0.1ml | EUR 424.8 |
Description: A polyclonal antibody for PKN1 (pThr774) from Human. The antibody is produced in rabbit after immunization with Human A phospho-specific peptide corresponding to residues surrounding Thr774 of human PKN1 (AA771-777). The Antibody is tested and validated for WB, AM assays with the following recommended dilutions: WB (1:250). This PKN1 (pThr774) antibody is unconjugated. |
Antibody for Human PKN1 (pThr774) |
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SPC-1065D-A390 | Stressmarq | 0.1ml | EUR 481.2 |
Description: A polyclonal antibody for PKN1 (pThr774) from Human. The antibody is produced in rabbit after immunization with Human A phospho-specific peptide corresponding to residues surrounding Thr774 of human PKN1 (AA771-777). The Antibody is tested and validated for WB, AM assays with the following recommended dilutions: WB (1:250). This PKN1 (pThr774) antibody is conjugated to ATTO 390. |
Antibody for Human PKN1 (pThr774) |
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SPC-1065D-A488 | Stressmarq | 0.1ml | EUR 480 |
Description: A polyclonal antibody for PKN1 (pThr774) from Human. The antibody is produced in rabbit after immunization with Human A phospho-specific peptide corresponding to residues surrounding Thr774 of human PKN1 (AA771-777). The Antibody is tested and validated for WB, AM assays with the following recommended dilutions: WB (1:250). This PKN1 (pThr774) antibody is conjugated to ATTO 488. |
Antibody for Human PKN1 (pThr774) |
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SPC-1065D-A565 | Stressmarq | 0.1ml | EUR 480 |
Description: A polyclonal antibody for PKN1 (pThr774) from Human. The antibody is produced in rabbit after immunization with Human A phospho-specific peptide corresponding to residues surrounding Thr774 of human PKN1 (AA771-777). The Antibody is tested and validated for WB, AM assays with the following recommended dilutions: WB (1:250). This PKN1 (pThr774) antibody is conjugated to ATTO 565. |
Antibody for Human PKN1 (pThr774) |
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SPC-1065D-A594 | Stressmarq | 0.1ml | EUR 480 |
Description: A polyclonal antibody for PKN1 (pThr774) from Human. The antibody is produced in rabbit after immunization with Human A phospho-specific peptide corresponding to residues surrounding Thr774 of human PKN1 (AA771-777). The Antibody is tested and validated for WB, AM assays with the following recommended dilutions: WB (1:250). This PKN1 (pThr774) antibody is conjugated to ATTO 594. |
Antibody for Human PKN1 (pThr774) |
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SPC-1065D-A633 | Stressmarq | 0.1ml | EUR 480 |
Description: A polyclonal antibody for PKN1 (pThr774) from Human. The antibody is produced in rabbit after immunization with Human A phospho-specific peptide corresponding to residues surrounding Thr774 of human PKN1 (AA771-777). The Antibody is tested and validated for WB, AM assays with the following recommended dilutions: WB (1:250). This PKN1 (pThr774) antibody is conjugated to ATTO 633. |
Antibody for Human PKN1 (pThr774) |
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SPC-1065D-A655 | Stressmarq | 0.1ml | EUR 480 |
Description: A polyclonal antibody for PKN1 (pThr774) from Human. The antibody is produced in rabbit after immunization with Human A phospho-specific peptide corresponding to residues surrounding Thr774 of human PKN1 (AA771-777). The Antibody is tested and validated for WB, AM assays with the following recommended dilutions: WB (1:250). This PKN1 (pThr774) antibody is conjugated to ATTO 655. |
Antibody for Human PKN1 (pThr774) |
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SPC-1065D-A680 | Stressmarq | 0.1ml | EUR 480 |
Description: A polyclonal antibody for PKN1 (pThr774) from Human. The antibody is produced in rabbit after immunization with Human A phospho-specific peptide corresponding to residues surrounding Thr774 of human PKN1 (AA771-777). The Antibody is tested and validated for WB, AM assays with the following recommended dilutions: WB (1:250). This PKN1 (pThr774) antibody is conjugated to ATTO 680. |
Antibody for Human PKN1 (pThr774) |
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SPC-1065D-A700 | Stressmarq | 0.1ml | EUR 480 |
Description: A polyclonal antibody for PKN1 (pThr774) from Human. The antibody is produced in rabbit after immunization with Human A phospho-specific peptide corresponding to residues surrounding Thr774 of human PKN1 (AA771-777). The Antibody is tested and validated for WB, AM assays with the following recommended dilutions: WB (1:250). This PKN1 (pThr774) antibody is conjugated to ATTO 700. |
Antibody for Human PKN1 (pThr774) |
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SPC-1065D-ALP | Stressmarq | 0.1ml | EUR 472.8 |
Description: A polyclonal antibody for PKN1 (pThr774) from Human. The antibody is produced in rabbit after immunization with Human A phospho-specific peptide corresponding to residues surrounding Thr774 of human PKN1 (AA771-777). The Antibody is tested and validated for WB, AM assays with the following recommended dilutions: WB (1:250). This PKN1 (pThr774) antibody is conjugated to Alkaline Phosphatase. |
Antibody for Human PKN1 (pThr774) |
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SPC-1065D-APC | Stressmarq | 0.1ml | EUR 478.8 |
Description: A polyclonal antibody for PKN1 (pThr774) from Human. The antibody is produced in rabbit after immunization with Human A phospho-specific peptide corresponding to residues surrounding Thr774 of human PKN1 (AA771-777). The Antibody is tested and validated for WB, AM assays with the following recommended dilutions: WB (1:250). This PKN1 (pThr774) antibody is conjugated to APC . |
Antibody for Human PKN1 (pThr774) |
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SPC-1065D-APCCY7 | Stressmarq | 0.1ml | EUR 565.2 |
Description: A polyclonal antibody for PKN1 (pThr774) from Human. The antibody is produced in rabbit after immunization with Human A phospho-specific peptide corresponding to residues surrounding Thr774 of human PKN1 (AA771-777). The Antibody is tested and validated for WB, AM assays with the following recommended dilutions: WB (1:250). This PKN1 (pThr774) antibody is conjugated to APC/Cy7. |
Antibody for Human PKN1 (pThr774) |
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SPC-1065D-BI | Stressmarq | 0.1ml | EUR 475.2 |
Description: A polyclonal antibody for PKN1 (pThr774) from Human. The antibody is produced in rabbit after immunization with Human A phospho-specific peptide corresponding to residues surrounding Thr774 of human PKN1 (AA771-777). The Antibody is tested and validated for WB, AM assays with the following recommended dilutions: WB (1:250). This PKN1 (pThr774) antibody is conjugated to Biotin. |
Antibody for Human PKN1 (pThr774) |
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SPC-1065D-DY350 | Stressmarq | 0.1ml | EUR 570 |
Description: A polyclonal antibody for PKN1 (pThr774) from Human. The antibody is produced in rabbit after immunization with Human A phospho-specific peptide corresponding to residues surrounding Thr774 of human PKN1 (AA771-777). The Antibody is tested and validated for WB, AM assays with the following recommended dilutions: WB (1:250). This PKN1 (pThr774) antibody is conjugated to Dylight 350. |
Antibody for Human PKN1 (pThr774) |
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SPC-1065D-DY405 | Stressmarq | 0.1ml | EUR 542.4 |
Description: A polyclonal antibody for PKN1 (pThr774) from Human. The antibody is produced in rabbit after immunization with Human A phospho-specific peptide corresponding to residues surrounding Thr774 of human PKN1 (AA771-777). The Antibody is tested and validated for WB, AM assays with the following recommended dilutions: WB (1:250). This PKN1 (pThr774) antibody is conjugated to Dylight 405. |
Antibody for Human PKN1 (pThr774) |
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SPC-1065D-DY488 | Stressmarq | 0.1ml | EUR 518.4 |
Description: A polyclonal antibody for PKN1 (pThr774) from Human. The antibody is produced in rabbit after immunization with Human A phospho-specific peptide corresponding to residues surrounding Thr774 of human PKN1 (AA771-777). The Antibody is tested and validated for WB, AM assays with the following recommended dilutions: WB (1:250). This PKN1 (pThr774) antibody is conjugated to Dylight 488. |
Antibody for Human PKN1 (pThr774) |
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SPC-1065D-DY594 | Stressmarq | 0.1ml | EUR 523.2 |
Description: A polyclonal antibody for PKN1 (pThr774) from Human. The antibody is produced in rabbit after immunization with Human A phospho-specific peptide corresponding to residues surrounding Thr774 of human PKN1 (AA771-777). The Antibody is tested and validated for WB, AM assays with the following recommended dilutions: WB (1:250). This PKN1 (pThr774) antibody is conjugated to Dylight 594. |
Antibody for Human PKN1 (pThr774) |
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SPC-1065D-DY633 | Stressmarq | 0.1ml | EUR 511.2 |
Description: A polyclonal antibody for PKN1 (pThr774) from Human. The antibody is produced in rabbit after immunization with Human A phospho-specific peptide corresponding to residues surrounding Thr774 of human PKN1 (AA771-777). The Antibody is tested and validated for WB, AM assays with the following recommended dilutions: WB (1:250). This PKN1 (pThr774) antibody is conjugated to Dylight 633. |
Antibody for Human PKN1 (pThr774) |
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SPC-1065D-FITC | Stressmarq | 0.1ml | EUR 470.4 |
Description: A polyclonal antibody for PKN1 (pThr774) from Human. The antibody is produced in rabbit after immunization with Human A phospho-specific peptide corresponding to residues surrounding Thr774 of human PKN1 (AA771-777). The Antibody is tested and validated for WB, AM assays with the following recommended dilutions: WB (1:250). This PKN1 (pThr774) antibody is conjugated to FITC. |
Antibody for Human PKN1 (pThr774) |
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SPC-1065D-HRP | Stressmarq | 0.1ml | EUR 465.6 |
Description: A polyclonal antibody for PKN1 (pThr774) from Human. The antibody is produced in rabbit after immunization with Human A phospho-specific peptide corresponding to residues surrounding Thr774 of human PKN1 (AA771-777). The Antibody is tested and validated for WB, AM assays with the following recommended dilutions: WB (1:250). This PKN1 (pThr774) antibody is conjugated to HRP. |
Antibody for Human PKN1 (pThr774) |
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SPC-1065D-P594 | Stressmarq | 0.1ml | EUR 488.4 |
Description: A polyclonal antibody for PKN1 (pThr774) from Human. The antibody is produced in rabbit after immunization with Human A phospho-specific peptide corresponding to residues surrounding Thr774 of human PKN1 (AA771-777). The Antibody is tested and validated for WB, AM assays with the following recommended dilutions: WB (1:250). This PKN1 (pThr774) antibody is conjugated to PE/ATTO 594. |
Antibody for Human PKN1 (pThr774) |
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SPC-1065D-PCP | Stressmarq | 0.1ml | EUR 478.8 |
Description: A polyclonal antibody for PKN1 (pThr774) from Human. The antibody is produced in rabbit after immunization with Human A phospho-specific peptide corresponding to residues surrounding Thr774 of human PKN1 (AA771-777). The Antibody is tested and validated for WB, AM assays with the following recommended dilutions: WB (1:250). This PKN1 (pThr774) antibody is conjugated to PerCP. |
Antibody for Human PKN1 (pThr774) |
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SPC-1065D-RPE | Stressmarq | 0.1ml | EUR 476.4 |
Description: A polyclonal antibody for PKN1 (pThr774) from Human. The antibody is produced in rabbit after immunization with Human A phospho-specific peptide corresponding to residues surrounding Thr774 of human PKN1 (AA771-777). The Antibody is tested and validated for WB, AM assays with the following recommended dilutions: WB (1:250). This PKN1 (pThr774) antibody is conjugated to RPE . |
Antibody for Human PKN1 (pThr774) |
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SPC-1065D-STR | Stressmarq | 0.1ml | EUR 477.6 |
Description: A polyclonal antibody for PKN1 (pThr774) from Human. The antibody is produced in rabbit after immunization with Human A phospho-specific peptide corresponding to residues surrounding Thr774 of human PKN1 (AA771-777). The Antibody is tested and validated for WB, AM assays with the following recommended dilutions: WB (1:250). This PKN1 (pThr774) antibody is conjugated to Streptavidin. |
Serine/Threonine-Protein Kinase N1 (PKN1) Antibody |
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abx224112-100ug | Abbexa | 100 ug | EUR 493.2 |
Serine/Threonine-Protein Kinase N1 (PKN1) Antibody |
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abx149738-100ug | Abbexa | 100 ug | EUR 526.8 |
Serine/Threonine-Protein Kinase N1 (PKN1) Antibody |
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20-abx327640 | Abbexa |
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Serine/Threonine-Protein Kinase N1 (PKN1) Antibody |
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20-abx015170 | Abbexa |
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Protein Kinase N1 (PKN1) Polyclonal Antibody (Human) |
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4-PAA501Hu01 | Cloud-Clone |
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Description: A Rabbit polyclonal antibody against Human Protein Kinase N1 (PKN1) |
Protein Kinase N1 (PKN1) Polyclonal Antibody (Human), PE |
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4-PAA501Hu01-PE | Cloud-Clone |
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Description: A Rabbit polyclonal antibody against Human Protein Kinase N1 (PKN1). This antibody is labeled with PE. |
Protein Kinase N1 (PKN1) Polyclonal Antibody (Human), APC |
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4-PAA501Hu01-APC | Cloud-Clone |
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Description: A Rabbit polyclonal antibody against Human Protein Kinase N1 (PKN1). This antibody is labeled with APC. |
Protein Kinase N1 (PKN1) Polyclonal Antibody (Human), Cy3 |
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4-PAA501Hu01-Cy3 | Cloud-Clone |
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Description: A Rabbit polyclonal antibody against Human Protein Kinase N1 (PKN1). This antibody is labeled with Cy3. |
Protein Kinase N1 (PKN1) Polyclonal Antibody (Human), HRP |
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4-PAA501Hu01-HRP | Cloud-Clone |
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Description: A Rabbit polyclonal antibody against Human Protein Kinase N1 (PKN1). This antibody is labeled with HRP. |
Protein Kinase N1 (PKN1) Polyclonal Antibody (Human), FITC |
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4-PAA501Hu01-FITC | Cloud-Clone |
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Description: A Rabbit polyclonal antibody against Human Protein Kinase N1 (PKN1). This antibody is labeled with FITC. |
Pkn1/ Rat Pkn1 ELISA Kit |
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ELI-37289r | Lifescience Market | 96 Tests | EUR 1063.2 |
Protein Kinase N1 (PKN1) Polyclonal Antibody (Human), Biotinylated |
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4-PAA501Hu01-Biotin | Cloud-Clone |
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Description: A Rabbit polyclonal antibody against Human Protein Kinase N1 (PKN1). This antibody is labeled with Biotin. |
Protein Kinase N1 (PKN1) Polyclonal Antibody (Human), APC-Cy7 |
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4-PAA501Hu01-APC-Cy7 | Cloud-Clone |
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Description: A Rabbit polyclonal antibody against Human Protein Kinase N1 (PKN1). This antibody is labeled with APC-Cy7. |
Anti-PKN1 antibody |
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STJ190147 | St John's Laboratory | 200 µl | EUR 236.4 |
Description: Unconjugated Rabbit polyclonal to PKN1 |
Anti-PKN1 antibody |
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STJ110991 | St John's Laboratory | 100 µl | EUR 332.4 |
Description: The protein encoded by this gene belongs to the protein kinase C superfamily. This kinase is activated by Rho family of small G proteins and may mediate the Rho-dependent signaling pathway. This kinase can be activated by phospholipids and by limited proteolysis. The 3-phosphoinositide dependent protein kinase-1 (PDPK1/PDK1) is reported to phosphorylate this kinase, which may mediate insulin signals to the actin cytoskeleton. The proteolytic activation of this kinase by caspase-3 or related proteases during apoptosis suggests its role in signal transduction related to apoptosis. Alternatively spliced transcript variants encoding distinct isoforms have been observed. |
PKN1 siRNA |
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20-abx904045 | Abbexa |
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PKN1 siRNA |
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20-abx928745 | Abbexa |
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PKN1 siRNA |
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20-abx928746 | Abbexa |
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anti- PKN2 antibody |
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FNab06498 | FN Test | 100µg | EUR 606.3 |
Description: Antibody raised against PKN2 |
PKN1 Rabbit pAb |
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A0553-100ul | Abclonal | 100 ul | EUR 369.6 |
PKN1 Rabbit pAb |
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A0553-200ul | Abclonal | 200 ul | EUR 550.8 |
PKN1 Rabbit pAb |
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A0553-20ul | Abclonal | 20 ul | EUR 219.6 |
PKN1 Rabbit pAb |
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A0553-50ul | Abclonal | 50 ul | EUR 267.6 |
PKN1 cloning plasmid |
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CSB-CL623082HU-10ug | Cusabio | 10ug | EUR 1082.4 |
Description: A cloning plasmid for the PKN1 gene. |
PKN1 Blocking Peptide |
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20-abx063131 | Abbexa |
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PKN1 Blocking Peptide |
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DF4790-BP | Affbiotech | 1mg | EUR 234 |
Rat PKN1 ELISA Kit |
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ERP0125 | Abclonal | 96Tests | EUR 625.2 |
PKN1 (PRK1), GST-Tag |
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79678 | BPS Bioscience | 10 µg | EUR 410 |
Description: Human PKN1 protein, also known as PRK1, DBK, and PKN, GenBank Accession No. BC040061, a.a. 289-end, with N-terminal GST-Tag, expressed in an Sf9 insect cell using a baculovirus expression system. MW = 115 kDa. |
Goat PKN1 ELISA Kit |
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EGTP0125 | Abclonal | 96Tests | EUR 625.2 |
Mouse PKN1 ELISA Kit |
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EMP0125 | Abclonal | 96Tests | EUR 625.2 |
PKN1 ELISA KIT|Human |
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EF005461 | Lifescience Market | 96 Tests | EUR 826.8 |
Human PKN1 ELISA Kit |
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EHP0125 | Abclonal | 96Tests | EUR 625.2 |
Rabbit PKN1 ELISA Kit |
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ERTP0125 | Abclonal | 96Tests | EUR 625.2 |
Bovine PKN1 ELISA Kit |
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EBP0125 | Abclonal | 96Tests | EUR 625.2 |
Canine PKN1 ELISA Kit |
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ECP0125 | Abclonal | 96Tests | EUR 625.2 |
Rat PKN1 shRNA Plasmid |
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20-abx985442 | Abbexa |
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Porcine PKN1 ELISA Kit |
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EPP0125 | Abclonal | 96Tests | EUR 625.2 |
Anserini PKN1 ELISA Kit |
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EAP0125 | Abclonal | 96Tests | EUR 625.2 |
Human PKN1 shRNA Plasmid |
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20-abx953755 | Abbexa |
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