Protein misfolded oligomers from cell membranes and abrogates their cytotoxicity

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Trodusquemine displaces protein misfolded oligomers from cell membranes and abrogates their cytotoxicity through a generic mechanism

 

The onset and progression of numerous protein misfolding diseases are associated with the presence of oligomers formed during the aberrant aggregation of several different proteins, including amyloid-β (Aβ) in Alzheimer’s disease and α-synuclein (αS) in Parkinson’s disease.
These small, soluble aggregates are currently major targets for drug discovery. In this study, we show that trodusquemine, a naturally-occurring aminosterol, markedly reduces the cytotoxicity of αS, Aβ and HypF-N oligomers to human neuroblastoma cells by displacing the oligomers from cell membranes in the absence of any substantial morphological and structural changes to the oligomers.
These results indicate that the reduced toxicity results from a mechanism that is common to oligomers from different proteins, shed light on the origin of the toxicity of the most deleterious species associated with protein aggregation and suggest that aminosterols have the therapeutically-relevant potential to protect cells from the oligomer-induced cytotoxicity associated with numerous protein misfolding diseases.

Comparing supermarket loyalty card data with traditional diet survey data for understanding how protein is purchased and consumed in older adults for the UK, 2014-16

Background: Our ability to understand population-level dietary intake patterns is dependent on having access to high quality data. Diet surveys are common diet assessment methods, but can be limited by bias associated with under-reporting.
Food purchases tracked using supermarket loyalty card records may supplement traditional surveys, however they are rarely available to academics and policy makers. The aim of our study is to explore population level patterns of protein purchasing and consumption in ageing adults (40 years onwards).
Methods: We used diet survey data from the National Diet and Nutrition Survey (2014-16) on food consumption, and loyalty card records on food purchases from a major high street supermarket retailer (2016-17) covering the UK. We computed the percentage of total energy derived from protein, protein intake per kg of body mass, and percentage of protein acquired by food type.
Results: We found that protein consumption (as the percentage of total energy purchased) increased between ages 40-65 years, and declined thereafter. In comparison, protein purchased in supermarkets was roughly 2-2.5 percentage points lower at each year of age.
The proportion of adults meeting recommended levels of protein was lowest in age groups 55-69 and 70+. The time of protein consumption was skewed towards evening meals, with low intakes during breakfast or between main meals. Meat, fish and poultry dominated as sources of protein purchased and consumed, although adults also acquired a large share of their protein from dairy and bread, with little from plant protein.
Conclusions: Our study provides novel insights into how protein is purchased and consumed by ageing adults in the UK. Supermarket loyalty card data can reveal patterns of protein purchasing that when combined with traditional sources of dietary intake may enhance our understanding of dietary behaviors.
Keywords: Big data; Diet surveys; Population; Protein; Supermarket loyalty cards.
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Recombinant EBV EBNA1 Mosaic Protein, His, E.coli-100ug
QP11732-100ug 100ug
EUR 261.6

Recombinant EBV EBNA1 Mosaic Protein, His, E.coli-500ug
QP11732-500ug 500ug
EUR 795.6

Recombinant EBV EBNA1 Mosaic Protein (aa 1-90 & 408-498) [GST]
VAng-Lsx0111-100g 100 µg
EUR 759.6
Description: EBV EBNA1 Mosaic protein [GST], recombinant protein from E. coli.

Recombinant EBV EBNA1 Mosaic Protein (aa 1-90 & 408-498) [GST]
VAng-Lsx0111-500g 500 µg
EUR 2419.2
Description: EBV EBNA1 Mosaic protein [GST], recombinant protein from E. coli.

Recombinant EBV EBNA1 Mosaic Protein (aa 1-90 & 408-498) [His]
VAng-2528Lsx-100g 100 µg
EUR 555.6
Description: EBV EBNA1 Mosaic protein, His tag at C-terminus, recombinant protein from E. coli.

Recombinant EBV EBNA1 Mosaic Protein (aa 1-90 & 408-498) [His]
VAng-2528Lsx-1mg 1 mg
EUR 3360
Description: EBV EBNA1 Mosaic protein, His tag at C-terminus, recombinant protein from E. coli.

Recombinant EBV EBNA1 Mosaic Protein (aa 1-90 & 408-498) [His]
VAng-2528Lsx-500g 500 µg
EUR 2040
Description: EBV EBNA1 Mosaic protein, His tag at C-terminus, recombinant protein from E. coli.

EBNA1 protein
30-1925 500 ug
EUR 678
Description: Purified Recombinant EBNA1 protein

EBV EBNA protein
30-AE46 200 ug
EUR 900
Description: Purified recombinant EBV EBNA protein

EBNA1 protein (His tag)
80-1340 100 ug
EUR 289.2
Description: Purified recombinant EBNA1 protein (His tag)

Recombinant EBNA1 Protein [GST]
VAng-Lsx0122-100g 100 µg
EUR 818.4
Description: EBNA1 (EBV) (P03211) partial recombinant protein with GST tag expressed in E. coli.

EBNA1 Binding Protein 2 Protein
20-abx260778
  • EUR 4101.60
  • EUR 393.60
  • EUR 276.00
  • 1 mg
  • 20 ug
  • 5 ug

EBNA1 Binding Protein 2 (EBNA1BP2) Antibody
abx026949-400ul 400 ul
EUR 627.6

EBNA1 Binding Protein 2 (EBNA1BP2) Antibody
abx026949-80l 80 µl
EUR 343.2

EBNA1 Binding Protein 2 (EBNA1BP2) Antibody
20-abx123650
  • EUR 493.20
  • EUR 710.40
  • EUR 218.40
  • EUR 376.80
  • 100 ul
  • 200 ul
  • 20 ul
  • 50 ul

EBNA1BP2 EBNA1 Binding Protein 2 Human Recombinant Protein
PROTQ99848 Regular: 20ug
EUR 380.4
Description: Recombinant Human EBNA1BP2 produced in E. coli is a single polypeptide chain containing 329 amino acids (1-306) and having a molecular mass of 37.2kDa.;EBNA1BP2 is fused to a 23 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.

Recombinant EBNA1 Protein [His] (1.185 mg/mL)
VAng-0610Lsx-inquire inquire Ask for price
Description: Epstein-Barr Virus (EBV) Nuclear Antigen-1 (EBNA-1), recombinant protein from E. coli. MW 63 kDa, 1.185 mg/mL.

Recombinant EBNA1 Protein [His] (1.25 mg/mL)
VAng-0611Lsx-inquire inquire Ask for price
Description: Epstein-Barr Virus (EBV) Nuclear Antigen-1 (EBNA-1), recombinant protein from E. coli. MW 63 kDa, 1.25 mg/mL.

Recombinant (E.Coli, GST tag) Epstein-Barr Virus (EBV/HHV-4) Mosaic EBNA1
RP-347 100 ug
EUR 343.2

Epstein-Barr Virus (HHV-4) EBNA1 Protein
20-abx260340
  • EUR 1345.20
  • EUR 560.40
  • EUR 2364.00
  • 0.5 mg
  • 100 ug
  • 1 mg

Mouse EBNA1 Binding Protein 2 (EBNA1BP2) ELISA Kit
abx389130-96tests 96 tests
EUR 1093.2

Human EBNA1 Binding Protein 2 (EBNA1BP2) ELISA Kit
abx384822-96tests 96 tests
EUR 1093.2

Recombinant EBNA1 Protein (aa 1-90, 408-498) [GST]
VAng-Lsx0128-inquire inquire Ask for price
Description: EBV NA1 (aa 1-90, 408-498) [GST], recombinant protein from E. coli.

pCXWB- EBNA1
PVT10196 2 ug
EUR 361.2

Epstein-Barr Virus (HHV-4) Mosaic EBNA1 Protein
20-abx260113
  • EUR 1062.00
  • EUR 410.40
  • EUR 1646.40
  • 0.5 mg
  • 100 ug
  • 1 mg

EBV EBNA-1 IgG ELISA Kit
DEIA332 96T
EUR 618
Description: The EBVEBNA-1 IgG Antibody ELISA Test Kit has been designed for the the detectionand the quantitative determination of specific IgG antibodies against EBVEBNA-1 in serum and plasma.

EBV EBNA-1 IgA ELISA Kit
DEIA333 96T
EUR 618
Description: The EBVEBNA-1 IgA Antibody ELISA Test Kit has been designed for the the detectionand the quantitative determination of specific IgA antibodies against EBVEBNA-1 in serum and plasma.

EBV EBNA-1 IgM ELISA Kit
DEIA334 96T
EUR 618
Description: The EBVEBNA-1 IgM Antibody ELISA Test Kit has been designed for the the detectionand the quantitative determination of specific IgM antibodies against EBVEBNA-1 in serum and plasma.

Epstein-Barr Virus (EBV) Epstein-Bar Nuclear Antigen-1 (EBNA-1) Protein
abx061529-1mg 1 mg
EUR 2030.4

pCXWB- EBNA1 Plasmid
PVT7175 2 ug
EUR 319.2

EBV antigen EBNA-1 Antibody
abx140258-01mg 0.1 mg
EUR 393.6

EBNA1 (RFP-Bsd) Lentivirus
LVP1134-RB 1x107 IFU/ml x 200ul
EUR 418.8
Description: Premade lentivirus expressing Epstein Barr Virus' EBNA1 gene under EF1a promoter, containing RFP-Blasticidin dual marker.

EBNA1 (GFP-Puro) Lentivirus
LVP1134-GP 1x107 IFU/ml x 200ul
EUR 418.8
Description: Premade lentivirus expressing Epstein Barr Virus' EBNA1 gene under EF1a promoter, containing GFP-Puromycin dual marker.

EBNA1 (RFP-Bsd) Lentivirus in PBS
LVP1134-RB-PBS 1x107 IFU/ml x 200ul
EUR 852
Description: Concentrated lentivirus in PBS expressing Epstein Barr Virus' EBNA1 gene under EF1a promoter, containing RFP-Blasticidin dual marker.

EBNA1 (GFP-Puro) Lentivirus in PBS
LVP1134-GP-PBS 1x107 IFU/ml x 200ul
EUR 852
Description: Concentrated lentivirus in PBS expressing Epstein Barr Virus' EBNA1 gene under EF1a promoter, containing GFP-Puromycin dual marker.

HHV-4 recombinant mosaic EBNA1 antigen
00212-V-01mg 0,1 mg
EUR 321
Description: HHV-4 recombinant mosaic EBNA1 antigen. Region: 1-90/408-498aa

HHV-4 recombinant mosaic EBNA1 antigen
00212-V-1000ug 1000 ug
EUR 1539
Description: HHV-4 recombinant mosaic EBNA1 antigen. Region: 1-90/408-498aa

Recombinant Epstein-Barr Virus (HHV-4) Mosaic EBNA1
7-07786 100µg Ask for price

Recombinant Epstein-Barr Virus (HHV-4) Mosaic EBNA1
7-07787 500µg Ask for price

Recombinant Epstein-Barr Virus (HHV-4) Mosaic EBNA1
7-07788 1000µg Ask for price

Epstein-Barr Virus Nuclear Antigen 1 (EBNA1) Antibody
abx414510-01mg 0.1 mg
EUR 526.8

Custom Testing of Samples for Antibodies (IgA/IgG/IgM) to Epstein Barr Virus (EBV/HHV-4) proteins (EBNA-1/EA/VCA/ED) by ELISA
510-200-CUX Custom Ask for price

Recombinant Epstein-Barr Virus (HHV-4) EBNA1, His Tag
7-07789 100µg Ask for price

Recombinant Epstein-Barr Virus (HHV-4) EBNA1, His Tag
7-07790 500µg Ask for price

Recombinant Epstein-Barr Virus (HHV-4) EBNA1, His Tag
7-07791 1000µg Ask for price

Epstein-Barr virus Epstein-Barr nuclear antigen 1 (EBNA1)
1-CSB-EP365878EFA
  • EUR 606.00
  • EUR 318.00
  • EUR 2192.40
  • EUR 919.20
  • EUR 1461.60
  • EUR 402.00
  • 100ug
  • 10ug
  • 1MG
  • 200ug
  • 500ug
  • 50ug
Description: Recombinant Epstein-Barr virus Epstein-Barr nuclear antigen 1(EBNA1),partial expressed in E.coli

HHV-4 recombinant mosaic EBNA1 antigen. Region: 1-90/408-498aa
00212-V-100ugvial 100ug/vial
EUR 150
Description: HHV-4 recombinant mosaic EBNA1 antigen. Region: 1-90/408-498aa

Goat Anti-EBV EBNA-1 Polyclonal antibody [HRP]
CABT-RM208 1 ml
EUR 982.8

Human Epstein-Barr virus nuclear antigen (EBNA1) antibody (IgG) ELISA kit
CSB-EQ027763HU-24T 1 plate of 24 wells
EUR 198
Description: Qualitativeindirect ELISA kit for measuring Human Epstein-Barr virus nuclear antigen (EBNA1) antibody (IgG) in samples from serum. A new trial version of the kit, which allows you to test the kit in your application at a reasonable price.

Human Epstein-Barr virus nuclear antigen (EBNA1) antibody (IgG) ELISA kit
1-CSB-EQ027763HU
  • EUR 964.80
  • EUR 6118.80
  • EUR 3244.80
  • 1 plate of 96 wells
  • 10 plates of 96 wells each
  • 5 plates of 96 wells each
Description: Qualitativeindirect ELISA kit for measuring Human Epstein-Barr virus nuclear antigen (EBNA1) antibody (IgG) in samples from serum. Now available in a cost efficient pack of 5 plates of 96 wells each, conveniently packed along with the other reagents in 5 separate kits.

EBNA1BP2 protein (His tag)
80R-3035 100 ug
EUR 392.4
Description: Purified recombinant EBNA1BP2 protein (His tag)

EBNA protein
30-AE47 1 mg
EUR 486
Description: Purified native EBNA protein

EBV protein
30-1275 1 mg
EUR 4177.2
Description: Purified recombinant EBV protein

EBV protein
30-1276 1 mg
EUR 4177.2
Description: Purified recombinant EBV protein

EBV Protein
abx069822-1ml 1 ml
EUR 828

EBV Protein
abx069824-1mg 1 mg
EUR 1762.8

EBV Protein
abx069825-1ml 1 ml
EUR 376.8

EBV Protein
abx069828-1mg 1 mg
EUR 2180.4

EBV Protein
abx069829-1mg 1 mg
EUR 2131.2

Human Anti-Epstein Barr Virus (EBV/HHV-4) Nuclear Antigen 1 (EBNA-1) IgA ELISA Kit, 96 tests, quantitative
510-200-HEA 1 Kit
EUR 708

Human Anti-Epstein Barr Virus (EBV/HHV-4) Nuclear Antigen 1 (EBNA-1) IgG ELISA Kit, 96 tests, quantitative
510-205-HEG 1 Kit
EUR 708

Human Anti-Epstein Barr Virus (EBV/HHV-4) Nuclear Antigen 1 (EBNA-1) IgM ELISA Kit, 96 tests, quantitative
510-210-HEM 1 Kit
EUR 708

Anti-EBV-EBNA1 antibody
STJ16101052 100 µg
EUR 424.8

EBNA1BP2 Recombinant Protein (Rat)
RP198986 100 ug Ask for price

EBNA1BP2 Recombinant Protein (Human)
RP010111 100 ug Ask for price

EBNA1BP2 Recombinant Protein (Mouse)
RP130700 100 ug Ask for price

EBNA1BP2 Protein Vector (Rat) (pPM-C-HA)
PV265320 500 ng
EUR 723.6

EBNA1BP2 Protein Vector (Rat) (pPB-C-His)
PV265318 500 ng
EUR 723.6

EBNA1BP2 Protein Vector (Rat) (pPB-N-His)
PV265319 500 ng
EUR 723.6

EBNA1BP2 Protein Vector (Rat) (pPM-C-His)
PV265321 500 ng
EUR 723.6

EBNA1BP2 Protein Vector (Human) (pPM-C-HA)
PV013483 500 ng
EUR 394.8

EBNA1BP2 Protein Vector (Mouse) (pPM-C-HA)
PV174272 500 ng
EUR 723.6

EBNA1BP2 Protein Vector (Human) (pPB-C-His)
PV013481 500 ng
EUR 394.8

EBNA1BP2 Protein Vector (Human) (pPB-N-His)
PV013482 500 ng
EUR 394.8

EBNA1BP2 Protein Vector (Human) (pPM-C-His)
PV013484 500 ng
EUR 394.8

EBNA1BP2 Protein Vector (Mouse) (pPB-C-His)
PV174270 500 ng
EUR 723.6

EBNA1BP2 Protein Vector (Mouse) (pPB-N-His)
PV174271 500 ng
EUR 723.6

EBNA1BP2 Protein Vector (Mouse) (pPM-C-His)
PV174273 500 ng
EUR 723.6

EBV EA protein
30R-AE005 100 ug
EUR 392.4
Description: Purified recombinant EBV EA protein

EBV EA protein
30-1280 1 mg
EUR 4177.2
Description: Purified recombinant EBV EA protein

EBV EA protein
30-1920 1 ml
EUR 496.8
Description: Viral lysate containing a high concentration of EBV antigens, including VCA, EBNA, EA-D and EA-R

The role of monoamine oxidase A in HPV-16 E7-induced epithelial-mesenchymal transition and HIF-1α protein accumulation in non-small cell lung cancer cells

 

Our previous studies have found that human papillomavirus (HPV)-16 E7 oncoprotein promotes epithelial-mesenchymal transition (EMT) and hypoxia-inducible factor-1α (HIF-1α) protein accumulation in non-small cell lung cancer (NSCLC) cells and monoamine oxidase A (MAOA) is highly expressed in NSCLC tissues.
Here, we further explored the role of MAOA in HPV-16 E7-induced EMT and HIF-1α protein accumulation in A549 and NCI-H460 NSCLC cells. Our results showed that HPV-16 E7 enhanced MAOA expression in NSCLC cells. Additionally, MAOA knockout inhibited HPV-16 E7-induced migration, invasion, and EMT, and significantly reduced HPV-16 E7-induced ROS generation and HIF-1α protein accumulation via promoting its degradation.
Furthermore, MAOA knockout suppressed HPV-16 E7-induced ERK1/2 activation. In vivo, MAOA knockout inhibited tumor growth, metastasis, and the expression of EMT-related markers and HIF-1α proteins induced by HPV-16 E7 in NCI-H460 NSCLC subcutaneous xenograft and in situ intrapulmonary models of nude mice. Taken together, our findings provide evidence that MAOA plays a key role in EMT and HIF-1α protein accumulation induced by HPV-16 E7 in NSCLC cells, suggesting that MAOA may be a potential therapeutic target for HPV-related NSCLC.

PKN1 Conjugated Antibody
C48392 100ul
EUR 476.4

PKN1 Polyclonal Antibody
ABP59926-003ml 0.03ml
EUR 189.6
Description: A polyclonal antibody for detection of PKN1 from Human, Mouse, Rat. This PKN1 antibody is for WB, ELISA. It is affinity-purified from rabbit serum by affinity-chromatography using the specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from part region of human PKN1 protein at amino acid sequence of 720-800

PKN1 Polyclonal Antibody
ABP59926-01ml 0.1ml
EUR 346.8
Description: A polyclonal antibody for detection of PKN1 from Human, Mouse, Rat. This PKN1 antibody is for WB, ELISA. It is affinity-purified from rabbit serum by affinity-chromatography using the specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from part region of human PKN1 protein at amino acid sequence of 720-800

PKN1 Polyclonal Antibody
ABP59926-02ml 0.2ml
EUR 496.8
Description: A polyclonal antibody for detection of PKN1 from Human, Mouse, Rat. This PKN1 antibody is for WB, ELISA. It is affinity-purified from rabbit serum by affinity-chromatography using the specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from part region of human PKN1 protein at amino acid sequence of 720-800

PKN1 Polyclonal Antibody
ES8989-100ul 100ul
EUR 334.8
Description: A Rabbit Polyclonal antibody against PKN1 from Human/Mouse/Rat. This antibody is tested and validated for WB, ELISA, WB, ELISA

PKN1 Polyclonal Antibody
ES8989-50ul 50ul
EUR 248.4
Description: A Rabbit Polyclonal antibody against PKN1 from Human/Mouse/Rat. This antibody is tested and validated for WB, ELISA, WB, ELISA

PKN1 Antibody (C-Terminal)
F53997-0.05ML 0.05 ml
EUR 140.25
Description: PKC-related serine/threonine-protein kinase involved in various processes such as regulation of the intermediate filaments of the actin cytoskeleton, cell migration, tumor cell invasion and transcription regulation. Regulates the cytoskeletal network by phosphorylating proteins such as VIM and neurofilament proteins NEFH, NEFL and NEFM, leading to inhibit their polymerization. Phosphorylates 'Ser-575', 'Ser-637' and 'Ser-669' of MAPT/Tau, lowering its ability to bind to microtubules, resulting in disruption of tubulin assembly. Acts as a key coactivator of androgen receptor (ANDR)-dependent transcription, by being recruited to ANDR target genes and specifically mediating phosphorylation of 'Thr-11' of histone H3 (H3T11ph), a specific tag for epigenetic transcriptional activation that promotes demethylation of histone H3 'Lys-9' (H3K9me) by KDM4C/JMJD2C. Phosphorylates HDAC5, HDAC7 and HDAC9, leading to impair their import in the nucleus. Phosphorylates 'Thr-38' of PPP1R14A, 'Ser- 159', 'Ser-163' and 'Ser-170' of MARCKS, and GFAP. Able to phosphorylate RPS6 in vitro.

PKN1 Antibody (C-Terminal)
F53997-0.2ML 0.2 ml
EUR 322.15
Description: PKC-related serine/threonine-protein kinase involved in various processes such as regulation of the intermediate filaments of the actin cytoskeleton, cell migration, tumor cell invasion and transcription regulation. Regulates the cytoskeletal network by phosphorylating proteins such as VIM and neurofilament proteins NEFH, NEFL and NEFM, leading to inhibit their polymerization. Phosphorylates 'Ser-575', 'Ser-637' and 'Ser-669' of MAPT/Tau, lowering its ability to bind to microtubules, resulting in disruption of tubulin assembly. Acts as a key coactivator of androgen receptor (ANDR)-dependent transcription, by being recruited to ANDR target genes and specifically mediating phosphorylation of 'Thr-11' of histone H3 (H3T11ph), a specific tag for epigenetic transcriptional activation that promotes demethylation of histone H3 'Lys-9' (H3K9me) by KDM4C/JMJD2C. Phosphorylates HDAC5, HDAC7 and HDAC9, leading to impair their import in the nucleus. Phosphorylates 'Thr-38' of PPP1R14A, 'Ser- 159', 'Ser-163' and 'Ser-170' of MARCKS, and GFAP. Able to phosphorylate RPS6 in vitro.

PKN1 Antibody (C-Terminal)
F53997-005ML 0.05 ml
EUR 165

PKN1/PRK1 Conjugated Antibody
C35295 100ul
EUR 476.4

Protein Kinase N1 (PKN1) Antibody
20-abx135704
  • EUR 493.20
  • EUR 710.40
  • EUR 218.40
  • EUR 376.80
  • 100 ul
  • 200 ul
  • 20 ul
  • 50 ul

Protein Kinase N1 (PKN1) Antibody
20-abx101658
  • EUR 360.00
  • EUR 159.60
  • EUR 895.20
  • EUR 477.60
  • EUR 309.60
  • 100 ug
  • 10 ug
  • 1 mg
  • 200 ug
  • 50 ug

Protein Kinase N1 (PKN1) Antibody
20-abx174267
  • EUR 944.40
  • EUR 493.20
  • 1 mg
  • 200 ug

Protein Kinase N1 (PKN1) Antibody
20-abx008827
  • EUR 360.00
  • EUR 526.80
  • EUR 226.80
  • 100 ul
  • 200 ul
  • 30 ul

Monoclonal PKN1 Antibody, Clone: 4H10B1
AMM03009G 0.1ml
EUR 633.6
Description: A Monoclonal antibody against Human PKN1. The antibodies are raised in Mouse and are from clone 4H10B1. This antibody is applicable in WB and IHC, FC, ICC, E

Monoclonal PKN1 Antibody, Clone: EPR3238
AMM07214G 0.1ml
EUR 633.6
Description: A Monoclonal antibody against Human PKN1. The antibodies are raised in Rabbit and are from clone EPR3238. This antibody is applicable in WB, FC

Antibody for Human PKN1 (pThr774)
SPC-1065D 0.1ml
EUR 424.8
Description: A polyclonal antibody for PKN1 (pThr774) from Human. The antibody is produced in rabbit after immunization with Human A phospho-specific peptide corresponding to residues surrounding Thr774 of human PKN1 (AA771-777). The Antibody is tested and validated for WB, AM assays with the following recommended dilutions: WB (1:250). This PKN1 (pThr774) antibody is unconjugated.

Antibody for Human PKN1 (pThr774)
SPC-1065D-A390 0.1ml
EUR 481.2
Description: A polyclonal antibody for PKN1 (pThr774) from Human. The antibody is produced in rabbit after immunization with Human A phospho-specific peptide corresponding to residues surrounding Thr774 of human PKN1 (AA771-777). The Antibody is tested and validated for WB, AM assays with the following recommended dilutions: WB (1:250). This PKN1 (pThr774) antibody is conjugated to ATTO 390.

Antibody for Human PKN1 (pThr774)
SPC-1065D-A488 0.1ml
EUR 480
Description: A polyclonal antibody for PKN1 (pThr774) from Human. The antibody is produced in rabbit after immunization with Human A phospho-specific peptide corresponding to residues surrounding Thr774 of human PKN1 (AA771-777). The Antibody is tested and validated for WB, AM assays with the following recommended dilutions: WB (1:250). This PKN1 (pThr774) antibody is conjugated to ATTO 488.

Antibody for Human PKN1 (pThr774)
SPC-1065D-A565 0.1ml
EUR 480
Description: A polyclonal antibody for PKN1 (pThr774) from Human. The antibody is produced in rabbit after immunization with Human A phospho-specific peptide corresponding to residues surrounding Thr774 of human PKN1 (AA771-777). The Antibody is tested and validated for WB, AM assays with the following recommended dilutions: WB (1:250). This PKN1 (pThr774) antibody is conjugated to ATTO 565.

Antibody for Human PKN1 (pThr774)
SPC-1065D-A594 0.1ml
EUR 480
Description: A polyclonal antibody for PKN1 (pThr774) from Human. The antibody is produced in rabbit after immunization with Human A phospho-specific peptide corresponding to residues surrounding Thr774 of human PKN1 (AA771-777). The Antibody is tested and validated for WB, AM assays with the following recommended dilutions: WB (1:250). This PKN1 (pThr774) antibody is conjugated to ATTO 594.

Antibody for Human PKN1 (pThr774)
SPC-1065D-A633 0.1ml
EUR 480
Description: A polyclonal antibody for PKN1 (pThr774) from Human. The antibody is produced in rabbit after immunization with Human A phospho-specific peptide corresponding to residues surrounding Thr774 of human PKN1 (AA771-777). The Antibody is tested and validated for WB, AM assays with the following recommended dilutions: WB (1:250). This PKN1 (pThr774) antibody is conjugated to ATTO 633.

Antibody for Human PKN1 (pThr774)
SPC-1065D-A655 0.1ml
EUR 480
Description: A polyclonal antibody for PKN1 (pThr774) from Human. The antibody is produced in rabbit after immunization with Human A phospho-specific peptide corresponding to residues surrounding Thr774 of human PKN1 (AA771-777). The Antibody is tested and validated for WB, AM assays with the following recommended dilutions: WB (1:250). This PKN1 (pThr774) antibody is conjugated to ATTO 655.

Antibody for Human PKN1 (pThr774)
SPC-1065D-A680 0.1ml
EUR 480
Description: A polyclonal antibody for PKN1 (pThr774) from Human. The antibody is produced in rabbit after immunization with Human A phospho-specific peptide corresponding to residues surrounding Thr774 of human PKN1 (AA771-777). The Antibody is tested and validated for WB, AM assays with the following recommended dilutions: WB (1:250). This PKN1 (pThr774) antibody is conjugated to ATTO 680.

Antibody for Human PKN1 (pThr774)
SPC-1065D-A700 0.1ml
EUR 480
Description: A polyclonal antibody for PKN1 (pThr774) from Human. The antibody is produced in rabbit after immunization with Human A phospho-specific peptide corresponding to residues surrounding Thr774 of human PKN1 (AA771-777). The Antibody is tested and validated for WB, AM assays with the following recommended dilutions: WB (1:250). This PKN1 (pThr774) antibody is conjugated to ATTO 700.

Antibody for Human PKN1 (pThr774)
SPC-1065D-ALP 0.1ml
EUR 472.8
Description: A polyclonal antibody for PKN1 (pThr774) from Human. The antibody is produced in rabbit after immunization with Human A phospho-specific peptide corresponding to residues surrounding Thr774 of human PKN1 (AA771-777). The Antibody is tested and validated for WB, AM assays with the following recommended dilutions: WB (1:250). This PKN1 (pThr774) antibody is conjugated to Alkaline Phosphatase.

Antibody for Human PKN1 (pThr774)
SPC-1065D-APC 0.1ml
EUR 478.8
Description: A polyclonal antibody for PKN1 (pThr774) from Human. The antibody is produced in rabbit after immunization with Human A phospho-specific peptide corresponding to residues surrounding Thr774 of human PKN1 (AA771-777). The Antibody is tested and validated for WB, AM assays with the following recommended dilutions: WB (1:250). This PKN1 (pThr774) antibody is conjugated to APC .

Antibody for Human PKN1 (pThr774)
SPC-1065D-APCCY7 0.1ml
EUR 565.2
Description: A polyclonal antibody for PKN1 (pThr774) from Human. The antibody is produced in rabbit after immunization with Human A phospho-specific peptide corresponding to residues surrounding Thr774 of human PKN1 (AA771-777). The Antibody is tested and validated for WB, AM assays with the following recommended dilutions: WB (1:250). This PKN1 (pThr774) antibody is conjugated to APC/Cy7.

Antibody for Human PKN1 (pThr774)
SPC-1065D-BI 0.1ml
EUR 475.2
Description: A polyclonal antibody for PKN1 (pThr774) from Human. The antibody is produced in rabbit after immunization with Human A phospho-specific peptide corresponding to residues surrounding Thr774 of human PKN1 (AA771-777). The Antibody is tested and validated for WB, AM assays with the following recommended dilutions: WB (1:250). This PKN1 (pThr774) antibody is conjugated to Biotin.

Antibody for Human PKN1 (pThr774)
SPC-1065D-DY350 0.1ml
EUR 570
Description: A polyclonal antibody for PKN1 (pThr774) from Human. The antibody is produced in rabbit after immunization with Human A phospho-specific peptide corresponding to residues surrounding Thr774 of human PKN1 (AA771-777). The Antibody is tested and validated for WB, AM assays with the following recommended dilutions: WB (1:250). This PKN1 (pThr774) antibody is conjugated to Dylight 350.

Antibody for Human PKN1 (pThr774)
SPC-1065D-DY405 0.1ml
EUR 542.4
Description: A polyclonal antibody for PKN1 (pThr774) from Human. The antibody is produced in rabbit after immunization with Human A phospho-specific peptide corresponding to residues surrounding Thr774 of human PKN1 (AA771-777). The Antibody is tested and validated for WB, AM assays with the following recommended dilutions: WB (1:250). This PKN1 (pThr774) antibody is conjugated to Dylight 405.

Antibody for Human PKN1 (pThr774)
SPC-1065D-DY488 0.1ml
EUR 518.4
Description: A polyclonal antibody for PKN1 (pThr774) from Human. The antibody is produced in rabbit after immunization with Human A phospho-specific peptide corresponding to residues surrounding Thr774 of human PKN1 (AA771-777). The Antibody is tested and validated for WB, AM assays with the following recommended dilutions: WB (1:250). This PKN1 (pThr774) antibody is conjugated to Dylight 488.

Antibody for Human PKN1 (pThr774)
SPC-1065D-DY594 0.1ml
EUR 523.2
Description: A polyclonal antibody for PKN1 (pThr774) from Human. The antibody is produced in rabbit after immunization with Human A phospho-specific peptide corresponding to residues surrounding Thr774 of human PKN1 (AA771-777). The Antibody is tested and validated for WB, AM assays with the following recommended dilutions: WB (1:250). This PKN1 (pThr774) antibody is conjugated to Dylight 594.

Antibody for Human PKN1 (pThr774)
SPC-1065D-DY633 0.1ml
EUR 511.2
Description: A polyclonal antibody for PKN1 (pThr774) from Human. The antibody is produced in rabbit after immunization with Human A phospho-specific peptide corresponding to residues surrounding Thr774 of human PKN1 (AA771-777). The Antibody is tested and validated for WB, AM assays with the following recommended dilutions: WB (1:250). This PKN1 (pThr774) antibody is conjugated to Dylight 633.

Antibody for Human PKN1 (pThr774)
SPC-1065D-FITC 0.1ml
EUR 470.4
Description: A polyclonal antibody for PKN1 (pThr774) from Human. The antibody is produced in rabbit after immunization with Human A phospho-specific peptide corresponding to residues surrounding Thr774 of human PKN1 (AA771-777). The Antibody is tested and validated for WB, AM assays with the following recommended dilutions: WB (1:250). This PKN1 (pThr774) antibody is conjugated to FITC.

Antibody for Human PKN1 (pThr774)
SPC-1065D-HRP 0.1ml
EUR 465.6
Description: A polyclonal antibody for PKN1 (pThr774) from Human. The antibody is produced in rabbit after immunization with Human A phospho-specific peptide corresponding to residues surrounding Thr774 of human PKN1 (AA771-777). The Antibody is tested and validated for WB, AM assays with the following recommended dilutions: WB (1:250). This PKN1 (pThr774) antibody is conjugated to HRP.

Antibody for Human PKN1 (pThr774)
SPC-1065D-P594 0.1ml
EUR 488.4
Description: A polyclonal antibody for PKN1 (pThr774) from Human. The antibody is produced in rabbit after immunization with Human A phospho-specific peptide corresponding to residues surrounding Thr774 of human PKN1 (AA771-777). The Antibody is tested and validated for WB, AM assays with the following recommended dilutions: WB (1:250). This PKN1 (pThr774) antibody is conjugated to PE/ATTO 594.

Antibody for Human PKN1 (pThr774)
SPC-1065D-PCP 0.1ml
EUR 478.8
Description: A polyclonal antibody for PKN1 (pThr774) from Human. The antibody is produced in rabbit after immunization with Human A phospho-specific peptide corresponding to residues surrounding Thr774 of human PKN1 (AA771-777). The Antibody is tested and validated for WB, AM assays with the following recommended dilutions: WB (1:250). This PKN1 (pThr774) antibody is conjugated to PerCP.

Antibody for Human PKN1 (pThr774)
SPC-1065D-RPE 0.1ml
EUR 476.4
Description: A polyclonal antibody for PKN1 (pThr774) from Human. The antibody is produced in rabbit after immunization with Human A phospho-specific peptide corresponding to residues surrounding Thr774 of human PKN1 (AA771-777). The Antibody is tested and validated for WB, AM assays with the following recommended dilutions: WB (1:250). This PKN1 (pThr774) antibody is conjugated to RPE .

Antibody for Human PKN1 (pThr774)
SPC-1065D-STR 0.1ml
EUR 477.6
Description: A polyclonal antibody for PKN1 (pThr774) from Human. The antibody is produced in rabbit after immunization with Human A phospho-specific peptide corresponding to residues surrounding Thr774 of human PKN1 (AA771-777). The Antibody is tested and validated for WB, AM assays with the following recommended dilutions: WB (1:250). This PKN1 (pThr774) antibody is conjugated to Streptavidin.

Serine/Threonine-Protein Kinase N1 (PKN1) Antibody
abx224112-100ug 100 ug
EUR 493.2

Serine/Threonine-Protein Kinase N1 (PKN1) Antibody
abx149738-100ug 100 ug
EUR 526.8

Serine/Threonine-Protein Kinase N1 (PKN1) Antibody
20-abx327640
  • EUR 376.80
  • EUR 292.80
  • 100 ug
  • 50 ug

Serine/Threonine-Protein Kinase N1 (PKN1) Antibody
20-abx015170
  • EUR 376.80
  • EUR 117.60
  • EUR 477.60
  • EUR 594.00
  • 100 ug
  • 10 ug
  • 200 ug
  • 300 µg

Protein Kinase N1 (PKN1) Polyclonal Antibody (Human)
4-PAA501Hu01
  • EUR 278.40
  • EUR 2726.40
  • EUR 685.20
  • EUR 345.60
  • EUR 248.40
  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
Description: A Rabbit polyclonal antibody against Human Protein Kinase N1 (PKN1)

Protein Kinase N1 (PKN1) Polyclonal Antibody (Human), PE
4-PAA501Hu01-PE
  • EUR 333.60
  • EUR 2856.00
  • EUR 822.00
  • EUR 415.20
  • EUR 224.40
  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
Description: A Rabbit polyclonal antibody against Human Protein Kinase N1 (PKN1). This antibody is labeled with PE.

Protein Kinase N1 (PKN1) Polyclonal Antibody (Human), APC
4-PAA501Hu01-APC
  • EUR 387.60
  • EUR 3541.20
  • EUR 997.20
  • EUR 488.40
  • EUR 250.80
  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
Description: A Rabbit polyclonal antibody against Human Protein Kinase N1 (PKN1). This antibody is labeled with APC.

Protein Kinase N1 (PKN1) Polyclonal Antibody (Human), Cy3
4-PAA501Hu01-Cy3
  • EUR 466.80
  • EUR 4671.60
  • EUR 1280.40
  • EUR 601.20
  • EUR 284.40
  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
Description: A Rabbit polyclonal antibody against Human Protein Kinase N1 (PKN1). This antibody is labeled with Cy3.

Protein Kinase N1 (PKN1) Polyclonal Antibody (Human), HRP
4-PAA501Hu01-HRP
  • EUR 355.20
  • EUR 3088.80
  • EUR 884.40
  • EUR 442.80
  • EUR 237.60
  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
Description: A Rabbit polyclonal antibody against Human Protein Kinase N1 (PKN1). This antibody is labeled with HRP.

Protein Kinase N1 (PKN1) Polyclonal Antibody (Human), FITC
4-PAA501Hu01-FITC
  • EUR 333.60
  • EUR 2856.00
  • EUR 822.00
  • EUR 415.20
  • EUR 224.40
  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
Description: A Rabbit polyclonal antibody against Human Protein Kinase N1 (PKN1). This antibody is labeled with FITC.

Pkn1/ Rat Pkn1 ELISA Kit
ELI-37289r 96 Tests
EUR 1063.2

Protein Kinase N1 (PKN1) Polyclonal Antibody (Human), Biotinylated
4-PAA501Hu01-Biotin
  • EUR 354.00
  • EUR 2666.40
  • EUR 801.60
  • EUR 428.40
  • EUR 254.40
  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
Description: A Rabbit polyclonal antibody against Human Protein Kinase N1 (PKN1). This antibody is labeled with Biotin.

Protein Kinase N1 (PKN1) Polyclonal Antibody (Human), APC-Cy7
4-PAA501Hu01-APC-Cy7
  • EUR 631.20
  • EUR 6938.40
  • EUR 1851.60
  • EUR 834.00
  • EUR 358.80
  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
Description: A Rabbit polyclonal antibody against Human Protein Kinase N1 (PKN1). This antibody is labeled with APC-Cy7.

Anti-PKN1 antibody
STJ190147 200 µl
EUR 236.4
Description: Unconjugated Rabbit polyclonal to PKN1

Anti-PKN1 antibody
STJ110991 100 µl
EUR 332.4
Description: The protein encoded by this gene belongs to the protein kinase C superfamily. This kinase is activated by Rho family of small G proteins and may mediate the Rho-dependent signaling pathway. This kinase can be activated by phospholipids and by limited proteolysis. The 3-phosphoinositide dependent protein kinase-1 (PDPK1/PDK1) is reported to phosphorylate this kinase, which may mediate insulin signals to the actin cytoskeleton. The proteolytic activation of this kinase by caspase-3 or related proteases during apoptosis suggests its role in signal transduction related to apoptosis. Alternatively spliced transcript variants encoding distinct isoforms have been observed.

PKN1 siRNA
20-abx904045
  • EUR 661.20
  • EUR 878.40
  • 15 nmol
  • 30 nmol

PKN1 siRNA
20-abx928745
  • EUR 661.20
  • EUR 878.40
  • 15 nmol
  • 30 nmol

PKN1 siRNA
20-abx928746
  • EUR 661.20
  • EUR 878.40
  • 15 nmol
  • 30 nmol

anti- PKN2 antibody
FNab06498 100µg
EUR 606.3
Description: Antibody raised against PKN2

PKN1 Rabbit pAb
A0553-100ul 100 ul
EUR 369.6

PKN1 Rabbit pAb
A0553-200ul 200 ul
EUR 550.8

PKN1 Rabbit pAb
A0553-20ul 20 ul
EUR 219.6

PKN1 Rabbit pAb
A0553-50ul 50 ul
EUR 267.6

PKN1 cloning plasmid
CSB-CL623082HU-10ug 10ug
EUR 1082.4
Description: A cloning plasmid for the PKN1 gene.

PKN1 Blocking Peptide
20-abx063131
  • EUR 326.40
  • EUR 493.20
  • 1 mg
  • 5 mg

PKN1 Blocking Peptide
DF4790-BP 1mg
EUR 234

Rat PKN1 ELISA Kit
ERP0125 96Tests
EUR 625.2

PKN1 (PRK1), GST-Tag
79678 10 µg
EUR 410
Description: Human PKN1 protein, also known as PRK1, DBK, and PKN, GenBank Accession No. BC040061, a.a. 289-end, with N-terminal GST-Tag, expressed in an Sf9 insect cell using a baculovirus expression system. MW = 115 kDa.

Goat PKN1 ELISA Kit
EGTP0125 96Tests
EUR 625.2

Mouse PKN1 ELISA Kit
EMP0125 96Tests
EUR 625.2

PKN1 ELISA KIT|Human
EF005461 96 Tests
EUR 826.8

Human PKN1 ELISA Kit
EHP0125 96Tests
EUR 625.2

Rabbit PKN1 ELISA Kit
ERTP0125 96Tests
EUR 625.2

Bovine PKN1 ELISA Kit
EBP0125 96Tests
EUR 625.2

Canine PKN1 ELISA Kit
ECP0125 96Tests
EUR 625.2

Rat PKN1 shRNA Plasmid
20-abx985442
  • EUR 961.20
  • EUR 1345.20
  • 150 µg
  • 300 µg

Porcine PKN1 ELISA Kit
EPP0125 96Tests
EUR 625.2

Anserini PKN1 ELISA Kit
EAP0125 96Tests
EUR 625.2

Human PKN1 shRNA Plasmid
20-abx953755
  • EUR 961.20
  • EUR 1345.20
  • 150 µg
  • 300 µg

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