
Trodusquemine displaces protein misfolded oligomers from cell membranes and abrogates their cytotoxicity through a generic mechanism
The onset and progression of numerous protein misfolding diseases are associated with the presence of oligomers formed during the aberrant aggregation of several different proteins, including amyloid-β (Aβ) in Alzheimer’s disease and α-synuclein (αS) in Parkinson’s disease.
These small, soluble aggregates are currently major targets for drug discovery. In this study, we show that trodusquemine, a naturally-occurring aminosterol, markedly reduces the cytotoxicity of αS, Aβ and HypF-N oligomers to human neuroblastoma cells by displacing the oligomers from cell membranes in the absence of any substantial morphological and structural changes to the oligomers.
These results indicate that the reduced toxicity results from a mechanism that is common to oligomers from different proteins, shed light on the origin of the toxicity of the most deleterious species associated with protein aggregation and suggest that aminosterols have the therapeutically-relevant potential to protect cells from the oligomer-induced cytotoxicity associated with numerous protein misfolding diseases.
Comparing supermarket loyalty card data with traditional diet survey data for understanding how protein is purchased and consumed in older adults for the UK, 2014-16
Background: Our ability to understand population-level dietary intake patterns is dependent on having access to high quality data. Diet surveys are common diet assessment methods, but can be limited by bias associated with under-reporting.
Food purchases tracked using supermarket loyalty card records may supplement traditional surveys, however they are rarely available to academics and policy makers. The aim of our study is to explore population level patterns of protein purchasing and consumption in ageing adults (40 years onwards).
Methods: We used diet survey data from the National Diet and Nutrition Survey (2014-16) on food consumption, and loyalty card records on food purchases from a major high street supermarket retailer (2016-17) covering the UK. We computed the percentage of total energy derived from protein, protein intake per kg of body mass, and percentage of protein acquired by food type.
Results: We found that protein consumption (as the percentage of total energy purchased) increased between ages 40-65 years, and declined thereafter. In comparison, protein purchased in supermarkets was roughly 2-2.5 percentage points lower at each year of age.
The proportion of adults meeting recommended levels of protein was lowest in age groups 55-69 and 70+. The time of protein consumption was skewed towards evening meals, with low intakes during breakfast or between main meals. Meat, fish and poultry dominated as sources of protein purchased and consumed, although adults also acquired a large share of their protein from dairy and bread, with little from plant protein.
Conclusions: Our study provides novel insights into how protein is purchased and consumed by ageing adults in the UK. Supermarket loyalty card data can reveal patterns of protein purchasing that when combined with traditional sources of dietary intake may enhance our understanding of dietary behaviors.
Keywords: Big data; Diet surveys; Population; Protein; Supermarket loyalty cards.

choleratox
EBV EBNA1 [GST] |
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DAG1850 | Creative Diagnostics | 500 ug | EUR 2089.24 |
Description: Recombinant |
EBV EBNA1 Mosaic |
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ebv-271 | ProSpec Tany | 100µg | EUR 165 |
Description: Recombinant Epstein-Barr Virus (HHV-4) EBNA1 Mosaic |
EBV EBNA1 antibody |
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20-EG46 | Fitzgerald | 1 mg | EUR 90 |
Description: Goat polyclonal EBV EBNA1 antibody |
EBV EBNA1 antibody |
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MBS534723-1mg | MyBiosource | 1mg | EUR 240 |
Recombinant EBV EBNA1 Protein, His, E.coli-1mg |
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QP11731-1mg | EnQuireBio | 1mg | EUR 1873.2 |
Recombinant EBV EBNA1 Protein, His, E.coli-100ug |
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QP11731-100ug | EnQuireBio | 100ug | EUR 381.6 |
Recombinant EBV EBNA1 Protein, His, E.coli-500ug |
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QP11731-500ug | EnQuireBio | 500ug | EUR 1034.4 |
Recombinant EBV EBNA1 Mosaic Protein, His, E.coli-1mg |
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QP11732-1mg | EnQuireBio | 1mg | EUR 1273.2 |
Recombinant EBV EBNA1 Mosaic Protein, His, E.coli-100ug |
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QP11732-100ug | EnQuireBio | 100ug | EUR 261.6 |
Recombinant EBV EBNA1 Mosaic Protein, His, E.coli-500ug |
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QP11732-500ug | EnQuireBio | 500ug | EUR 795.6 |
Recombinant EBV EBNA1 Mosaic Protein (aa 1-90 & 408-498) [GST] |
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VAng-Lsx0111-100g | Creative Biolabs | 100 µg | EUR 759.6 |
Description: EBV EBNA1 Mosaic protein [GST], recombinant protein from E. coli. |
Recombinant EBV EBNA1 Mosaic Protein (aa 1-90 & 408-498) [GST] |
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VAng-Lsx0111-500g | Creative Biolabs | 500 µg | EUR 2419.2 |
Description: EBV EBNA1 Mosaic protein [GST], recombinant protein from E. coli. |
Recombinant EBV EBNA1 Mosaic Protein (aa 1-90 & 408-498) [His] |
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VAng-2528Lsx-100g | Creative Biolabs | 100 µg | EUR 555.6 |
Description: EBV EBNA1 Mosaic protein, His tag at C-terminus, recombinant protein from E. coli. |
Recombinant EBV EBNA1 Mosaic Protein (aa 1-90 & 408-498) [His] |
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VAng-2528Lsx-1mg | Creative Biolabs | 1 mg | EUR 3360 |
Description: EBV EBNA1 Mosaic protein, His tag at C-terminus, recombinant protein from E. coli. |
Recombinant EBV EBNA1 Mosaic Protein (aa 1-90 & 408-498) [His] |
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VAng-2528Lsx-500g | Creative Biolabs | 500 µg | EUR 2040 |
Description: EBV EBNA1 Mosaic protein, His tag at C-terminus, recombinant protein from E. coli. |
Recombinant EBV EBNA1 Antigen, His-tagged |
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VAC-0197 | Creative BioMart | 0.5ml | EUR 1598.4 |
Description: Protein |
EBV Nuclear Antigen EBNA1. p72 (stabilized) |
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BA1362R01 | Serion Immundiagnostica GmbH | 29 mg | EUR 715 |
Epstein Barr Virus, EBNA1, Recombinant (EBV) |
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MBS637565-01mg | MyBiosource | 0.1mg | EUR 845 |
Epstein Barr Virus, EBNA1, Recombinant (EBV) |
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MBS637565-5x01mg | MyBiosource | 5x0.1mg | EUR 3660 |
Recombinant EBV EBNA1 Mosaic Antigen, His-tagged |
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VAC-0198 | Creative BioMart | 0.5ml | EUR 1598.4 |
Description: Protein |
EBV EBNA protein |
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30-AE46 | Fitzgerald | 200 ug | EUR 667 |
Description: Purified recombinant EBV EBNA protein |
EBV EBNA protein |
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MBS538336-INQUIRE | MyBiosource | INQUIRE | Ask for price |
EBNA1 protein |
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30-1925 | Fitzgerald | 500 ug | EUR 495 |
Description: Purified Recombinant EBNA1 protein |
RECOMBINANT ANTIGEN EBNA1 from Epstein-Barr Virus (EBV) |
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MBS505053-1mg | MyBiosource | 1mg | EUR 1080 |
RECOMBINANT ANTIGEN EBNA1 from Epstein-Barr Virus (EBV) |
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MBS505053-5x1mg | MyBiosource | 5x1mg | EUR 4575 |
Epstein Barr Virus, Nuclear Antigen, EBNA1, Recombinant (EBV) |
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MBS636498-01mg | MyBiosource | 0.1mg | EUR 540 |
Epstein Barr Virus, Nuclear Antigen, EBNA1, Recombinant (EBV) |
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MBS636498-5x01mg | MyBiosource | 5x0.1mg | EUR 2275 |
EBNA1 protein (His tag) |
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80-1340 | Fitzgerald | 100 ug | EUR 233 |
Description: Purified recombinant EBNA1 protein (His tag) |
human anti-EBV NA1(EBNA1) IgA(4E3) |
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E4A11A68-4E3-A | EnoGene | 100ug | EUR 995 |
human anti-EBV NA1(EBNA1) IgG(4E3) |
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E4A11A68-4E3-G | EnoGene | 100ug | EUR 995 |
human anti-EBV NA1(EBNA1) IgM(4E3) |
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E4A11A68-4E3-M | EnoGene | 100ug | EUR 995 |
human anti-EBV NA1(EBNA1) IgA(4K9) |
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E4A11A68-4K9-A | EnoGene | 100ug | EUR 995 |
human anti-EBV NA1(EBNA1) IgG(4K9) |
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E4A11A68-4K9-G | EnoGene | 100ug | EUR 995 |
human anti-EBV NA1(EBNA1) IgM(4K9) |
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E4A11A68-4K9-M | EnoGene | 100ug | EUR 995 |
Recombinant EBNA1 Protein [GST] |
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VAng-Lsx0122-100g | Creative Biolabs | 100 µg | EUR 818.4 |
Description: EBNA1 (EBV) (P03211) partial recombinant protein with GST tag expressed in E. coli. |
Epstein Barr Virus, Nuclear Antigen, Recombinant EBNA1, 27kD CT (EBV) |
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MBS636094-01mg | MyBiosource | 0.1mg | EUR 755 |
Epstein Barr Virus, Nuclear Antigen, Recombinant EBNA1, 27kD CT (EBV) |
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MBS636094-5x01mg | MyBiosource | 5x0.1mg | EUR 3170 |
Purified Recombinant EBNA1 protein |
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MBS5308620-05mg | MyBiosource | 0.5mg | EUR 795 |
Purified Recombinant EBNA1 protein |
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MBS5308620-5x05mg | MyBiosource | 5x0.5mg | EUR 3430 |
EBNA1 Binding Protein 2 Protein |
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abx260778-10g | Abbexa | 10 µg | EUR 325 |
EBNA1 Binding Protein 2 Protein |
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20-abx260778 | Abbexa |
|
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EBNA1 Binding Protein 2 Protein |
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abx260778-2g | Abbexa | 2 µg | EUR 225 |
Epstein Barr Virus, Nuclear Antigen, EBNA1, Mosaic, Recombinant (aa1-90, 408-498) (EBV) |
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MBS638308-01mg | MyBiosource | 0.1mg | EUR 490 |
Epstein Barr Virus, Nuclear Antigen, EBNA1, Mosaic, Recombinant (aa1-90, 408-498) (EBV) |
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MBS638308-05mg | MyBiosource | 0.5mg | EUR 1065 |
Epstein Barr Virus, Nuclear Antigen, EBNA1, Mosaic, Recombinant (aa1-90, 408-498) (EBV) |
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MBS638308-5x05mg | MyBiosource | 5x0.5mg | EUR 4635 |
Anti-EBV/HHV-4 EBNA1/BKRF1 Antibody (3D4) |
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MBS1569155-01mg | MyBiosource | 0.1mg | EUR 405 |
Anti-EBV/HHV-4 EBNA1/BKRF1 Antibody (3D4) |
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MBS1569155-5x01mg | MyBiosource | 5x0.1mg | EUR 1520 |
Anti-EBV/HHV-4 EBNA1/BKRF1 Antibody (16D2) |
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MBS1569156-01mg | MyBiosource | 0.1mg | EUR 405 |
Anti-EBV/HHV-4 EBNA1/BKRF1 Antibody (16D2) |
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MBS1569156-5x01mg | MyBiosource | 5x0.1mg | EUR 1520 |
EBNA1 Binding Protein 2 (EBNA1BP2) Antibody |
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abx026949-400l | Abbexa | 400 µl | EUR 518.75 |
EBNA1 Binding Protein 2 (EBNA1BP2) Antibody |
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abx026949-400ul | Abbexa | 400 ul | EUR 627.6 |
EBNA1 Binding Protein 2 (EBNA1BP2) Antibody |
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abx026949-80l | Abbexa | 80 µl | EUR 281.25 |
EBNA1 Binding Protein 2 (EBNA1BP2) Antibody |
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abx123650-100l | Abbexa | 100 µl | EUR 175 |
EBNA1 Binding Protein 2 (EBNA1BP2) Antibody |
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20-abx123650 | Abbexa |
|
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EBNA1 Binding Protein 2 (EBNA1BP2) Antibody |
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abx123650-1ml | Abbexa | 1 ml | EUR 400 |
EBNA1 Binding Protein 2 (EBNA1BP2) Antibody |
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abx123650-200l | Abbexa | 200 µl | EUR 275 |
Recombinant (E.Coli, GST tag) Epstein-Barr Virus (EBV/HHV-4) Mosaic EBNA1 |
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RP-347 | Alpha Diagnostics | 100 ug | EUR 343.2 |
EBV Early Antigens (EBNA1, EBV nuclear antigen 1, Epstein Barr nuclear antigen 1, Human Herpesvirus 4 (HHV4)) (AP) |
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MBS6123099-01mL | MyBiosource | 0.1(mL | EUR 935 |
EBV Early Antigens (EBNA1, EBV nuclear antigen 1, Epstein Barr nuclear antigen 1, Human Herpesvirus 4 (HHV4)) (AP) |
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MBS6123099-5x01mL | MyBiosource | 5x0.1mL | EUR 4050 |
EBV Early Antigens (EBNA1, EBV nuclear antigen 1, Epstein Barr nuclear antigen 1, Human Herpesvirus 4 (HHV4)) (PE) |
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MBS6123103-01mL | MyBiosource | 0.1(mL | EUR 935 |
EBV Early Antigens (EBNA1, EBV nuclear antigen 1, Epstein Barr nuclear antigen 1, Human Herpesvirus 4 (HHV4)) (PE) |
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MBS6123103-5x01mL | MyBiosource | 5x0.1mL | EUR 4050 |
EBV Early Antigens (EBNA1, EBV nuclear antigen 1, Epstein Barr nuclear antigen 1, Human Herpesvirus 4 (HHV4)) (APC) |
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MBS6123100-01mL | MyBiosource | 0.1(mL | EUR 935 |
EBV Early Antigens (EBNA1, EBV nuclear antigen 1, Epstein Barr nuclear antigen 1, Human Herpesvirus 4 (HHV4)) (APC) |
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MBS6123100-5x01mL | MyBiosource | 5x0.1mL | EUR 4050 |
EBV Early Antigens (EBNA1, EBV nuclear antigen 1, Epstein Barr nuclear antigen 1, Human Herpesvirus 4 (HHV4)) (Biotin) |
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MBS6123101-01mL | MyBiosource | 0.1(mL | EUR 935 |
EBV Early Antigens (EBNA1, EBV nuclear antigen 1, Epstein Barr nuclear antigen 1, Human Herpesvirus 4 (HHV4)) (Biotin) |
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MBS6123101-5x01mL | MyBiosource | 5x0.1mL | EUR 4050 |
EBV Early Antigens (EBNA1, EBV nuclear antigen 1, Epstein Barr nuclear antigen 1, Human Herpesvirus 4 (HHV4)) (FITC) |
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MBS6123102-01mL | MyBiosource | 0.1(mL | EUR 935 |
EBV Early Antigens (EBNA1, EBV nuclear antigen 1, Epstein Barr nuclear antigen 1, Human Herpesvirus 4 (HHV4)) (FITC) |
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MBS6123102-5x01mL | MyBiosource | 5x0.1mL | EUR 4050 |
Purified recombinant EBNA1 protein (His tag) |
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MBS5308460-07mg | MyBiosource | 0.7mg | EUR 1185 |
Purified recombinant EBNA1 protein (His tag) |
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MBS5308460-5x07mg | MyBiosource | 5x0.7mg | EUR 5120 |
Recombinant EBNA1 Protein [His] (1.185 mg/mL) |
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VAng-0610Lsx-inquire | Creative Biolabs | inquire | Ask for price |
Description: Epstein-Barr Virus (EBV) Nuclear Antigen-1 (EBNA-1), recombinant protein from E. coli. MW 63 kDa, 1.185 mg/mL. |
Recombinant EBNA1 Protein [His] (1.25 mg/mL) |
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VAng-0611Lsx-inquire | Creative Biolabs | inquire | Ask for price |
Description: Epstein-Barr Virus (EBV) Nuclear Antigen-1 (EBNA-1), recombinant protein from E. coli. MW 63 kDa, 1.25 mg/mL. |
Epstein-Barr Virus (HHV-4) EBNA1 Protein |
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20-abx260340 | Abbexa |
|
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EBNA1 binding protein 2 (EBNA1BP2) (NM_006824) Human Recombinant Protein |
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E45H32372E1 | EnoGene | 50 ug | EUR 552.5 |
Human EBNA1 Binding Protein 2 (EBNA1BP2) ELISA Kit |
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abx384822-96tests | Abbexa | 96 tests | EUR 687.5 |
Mouse EBNA1 Binding Protein 2 (EBNA1BP2) ELISA Kit |
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abx389130-96tests | Abbexa | 96 tests | EUR 687.5 |
Epstein Barr Virus, Nuclear Antigen (Epstein-Barr Nuclear Antigen 1, EBV Nuclear Antigen 1, EBNA1, EBNA-1, EBV, BKRF1, Human Herpes virus 4, HHV4) |
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MBS609692-01mg | MyBiosource | 0.1mg | EUR 580 |
Epstein Barr Virus, Nuclear Antigen (Epstein-Barr Nuclear Antigen 1, EBV Nuclear Antigen 1, EBNA1, EBNA-1, EBV, BKRF1, Human Herpes virus 4, HHV4) |
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MBS609692-5x01mg | MyBiosource | 5x0.1mg | EUR 2470 |
EBV EBNA-1, Recombinant |
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MBS318777-1mg | MyBiosource | 1mg | EUR 1675 |
EBV EBNA-1, Recombinant |
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MBS318777-5x1mg | MyBiosource | 5x1mg | EUR 7255 |
Recombinant Human EBNA1 Binding Protein 2 |
|||
MBS145981-0005mg | MyBiosource | 0.005mg | EUR 240 |
Recombinant Human EBNA1 Binding Protein 2 |
|||
MBS145981-002mg | MyBiosource | 0.02mg | EUR 310 |
The role of monoamine oxidase A in HPV-16 E7-induced epithelial-mesenchymal transition and HIF-1α protein accumulation in non-small cell lung cancer cells
Our previous studies have found that human papillomavirus (HPV)-16 E7 oncoprotein promotes epithelial-mesenchymal transition (EMT) and hypoxia-inducible factor-1α (HIF-1α) protein accumulation in non-small cell lung cancer (NSCLC) cells and monoamine oxidase A (MAOA) is highly expressed in NSCLC tissues.
Here, we further explored the role of MAOA in HPV-16 E7-induced EMT and HIF-1α protein accumulation in A549 and NCI-H460 NSCLC cells. Our results showed that HPV-16 E7 enhanced MAOA expression in NSCLC cells. Additionally, MAOA knockout inhibited HPV-16 E7-induced migration, invasion, and EMT, and significantly reduced HPV-16 E7-induced ROS generation and HIF-1α protein accumulation via promoting its degradation.
Furthermore, MAOA knockout suppressed HPV-16 E7-induced ERK1/2 activation. In vivo, MAOA knockout inhibited tumor growth, metastasis, and the expression of EMT-related markers and HIF-1α proteins induced by HPV-16 E7 in NCI-H460 NSCLC subcutaneous xenograft and in situ intrapulmonary models of nude mice. Taken together, our findings provide evidence that MAOA plays a key role in EMT and HIF-1α protein accumulation induced by HPV-16 E7 in NSCLC cells, suggesting that MAOA may be a potential therapeutic target for HPV-related NSCLC.
PKN1 Antibody |
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DF4790-100ul | Affinity Biosciences | 100ul | EUR 168 |
Description: WB,IHC,IF/ICC,ELISA(peptide) |
PKN1 Antibody |
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DF4790-200ul | Affinity Biosciences | 200ul | EUR 210 |
Description: WB,IHC,IF/ICC,ELISA(peptide) |
PKN1 Antibody |
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E310870b | EnoGene | 200ul | EUR 275 |
Description: Available in various conjugation types. |
PKN1 Antibody |
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E38PA1937 | EnoGene | 100ul | EUR 225 |
Description: Available in various conjugation types. |
PKN1 Antibody |
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E19-4790 | EnoGene | 100μg/100μl | EUR 225 |
Description: Available in various conjugation types. |
PKN1 Antibody |
|||
E11-21184C | EnoGene | 100μg | EUR 225 |
Description: Available in various conjugation types. |
PKN1 Antibody |
|||
MBS5314876-01mL | MyBiosource | 0.1mL | EUR 470 |
PKN1 Antibody |
|||
MBS5314876-5x01mL | MyBiosource | 5x0.1mL | EUR 1955 |
PKN1 Antibody |
|||
MBS7120267-005mg | MyBiosource | 0.05mg | EUR 150 |
PKN1 Antibody |
|||
MBS7120267-01mg | MyBiosource | 0.1mg | EUR 190 |
PKN1 Antibody |
|||
MBS7120267-5x01mg | MyBiosource | 5x0.1mg | EUR 845 |
PKN1 Antibody |
|||
MBS8515493-01mg | MyBiosource | 0.1mg | EUR 305 |
PKN1 Antibody |
|||
MBS8515493-01mLAF405L | MyBiosource | 0.1mL(AF405L) | EUR 465 |
PKN1 Antibody |
|||
MBS8515493-01mLAF405S | MyBiosource | 0.1mL(AF405S) | EUR 465 |
PKN1 Antibody |
|||
MBS8515493-01mLAF610 | MyBiosource | 0.1mL(AF610) | EUR 465 |
PKN1 Antibody |
|||
MBS8515493-01mLAF635 | MyBiosource | 0.1mL(AF635) | EUR 465 |
PKN1 Antibody |
|||
MBS9233137-01mL | MyBiosource | 0.1mL | EUR 415 |
PKN1 Antibody |
|||
MBS9233137-5x01mL | MyBiosource | 5x0.1mL | EUR 1841 |
PKN1 Antibody |
|||
MBS858249-01mg | MyBiosource | 0.1mg | EUR 305 |
PKN1 Antibody |
|||
MBS858249-01mLAF405L | MyBiosource | 0.1mL(AF405L) | EUR 465 |
PKN1 Antibody |
|||
MBS858249-01mLAF405S | MyBiosource | 0.1mL(AF405S) | EUR 465 |
PKN1 Antibody |
|||
MBS858249-01mLAF610 | MyBiosource | 0.1mL(AF610) | EUR 465 |
PKN1 Antibody |
|||
MBS858249-01mLAF635 | MyBiosource | 0.1mL(AF635) | EUR 465 |
PKN1 Antibody |
|||
MBS8580951-01mL | MyBiosource | 0.1mL | EUR 305 |
PKN1 Antibody |
|||
MBS8580951-01mLAF405L | MyBiosource | 0.1mL(AF405L) | EUR 465 |
PKN1 Antibody |
|||
MBS8580951-01mLAF405S | MyBiosource | 0.1mL(AF405S) | EUR 465 |
PKN1 Antibody |
|||
MBS8580951-01mLAF610 | MyBiosource | 0.1mL(AF610) | EUR 465 |
PKN1 Antibody |
|||
MBS8580951-01mLAF635 | MyBiosource | 0.1mL(AF635) | EUR 465 |
PKN1 Antibody |
|||
MBS9606244-01mL | MyBiosource | 0.1mL | EUR 260 |
PKN1 Antibody |
|||
MBS9606244-02mL | MyBiosource | 0.2mL | EUR 305 |
PKN1 Antibody |
|||
MBS9606244-5x02mL | MyBiosource | 5x0.2mL | EUR 1220 |
PKN1 Antibody |
|||
MBS9435246-005mL | MyBiosource | 0.05mL | EUR 325 |
PKN1 Antibody |
|||
MBS9435246-01mL | MyBiosource | 0.1mL | EUR 445 |
PKN1 Antibody |
|||
MBS9435246-5x01mL | MyBiosource | 5x0.1mL | EUR 1860 |
PKN1/PRK1 Antibody |
|||
35295 | SAB | 100ul | EUR 319 |
PKN1/PRK1 Antibody |
|||
35295-100ul | SAB | 100ul | EUR 302.4 |
PKN1/PRK1 Antibody |
|||
35295-50ul | SAB | 50ul | EUR 224.4 |
PKN1/PRK1 Antibody |
|||
E035295 | EnoGene | 100μg/100μl | EUR 225 |
Description: Available in various conjugation types. |
PKN1/PRK1 Antibody |
|||
MBS9414191-005mL | MyBiosource | 0.05mL | EUR 245 |
PKN1/PRK1 Antibody |
|||
MBS9414191-01mL | MyBiosource | 0.1mL | EUR 305 |
PKN1/PRK1 Antibody |
|||
MBS9414191-5x01mL | MyBiosource | 5x0.1mL | EUR 1230 |
PKN1 Rabbit anti-Human Polyclonal Antibody |
|||
MBS2402435-005mL | MyBiosource | 0.05mL | EUR 615 |
PKN1 Rabbit anti-Human Polyclonal Antibody |
|||
MBS2402435-5x005mL | MyBiosource | 5x0.05mL | EUR 2605 |
PKN1 Polyclonal Antibody |
|||
ABP59926-003ml | Abbkine | 0.03ml | EUR 189.6 |
Description: A polyclonal antibody for detection of PKN1 from Human, Mouse, Rat. This PKN1 antibody is for WB, ELISA. It is affinity-purified from rabbit serum by affinity-chromatography using the specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from part region of human PKN1 protein at amino acid sequence of 720-800 |
PKN1 Polyclonal Antibody |
|||
ABP59926-01ml | Abbkine | 0.1ml | EUR 346.8 |
Description: A polyclonal antibody for detection of PKN1 from Human, Mouse, Rat. This PKN1 antibody is for WB, ELISA. It is affinity-purified from rabbit serum by affinity-chromatography using the specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from part region of human PKN1 protein at amino acid sequence of 720-800 |
PKN1 Polyclonal Antibody |
|||
ABP59926-02ml | Abbkine | 0.2ml | EUR 496.8 |
Description: A polyclonal antibody for detection of PKN1 from Human, Mouse, Rat. This PKN1 antibody is for WB, ELISA. It is affinity-purified from rabbit serum by affinity-chromatography using the specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from part region of human PKN1 protein at amino acid sequence of 720-800 |
PKN1 Conjugated Antibody |
|||
C48392 | SAB | 100ul | EUR 476.4 |
PKN1 Polyclonal Antibody |
|||
BT-AP13130-100ul | Jiaxing Korain Biotech Ltd (BT Labs) | 100ul | Ask for price |
Description: The protein encoded by this gene belongs to the protein kinase C superfamily. This kinase is activated by Rho family of small G proteins and may mediate the Rho-dependent signaling pathway. This kinase can be activated by phospholipids and by limited proteolysis. The 3-phosphoinositide dependent protein kinase-1 (PDPK1/PDK1) is reported to phosphorylate this kinase, which may mediate insulin signals to the actin cytoskeleton. The proteolytic activation of this kinase by caspase-3 or related proteases during apoptosis suggests its role in signal transduction related to apoptosis. Alternatively spliced transcript variants encoding distinct isoforms have been observed. |
PKN1 Polyclonal Antibody |
|||
BT-AP13130-20ul | Jiaxing Korain Biotech Ltd (BT Labs) | 20ul | Ask for price |
Description: The protein encoded by this gene belongs to the protein kinase C superfamily. This kinase is activated by Rho family of small G proteins and may mediate the Rho-dependent signaling pathway. This kinase can be activated by phospholipids and by limited proteolysis. The 3-phosphoinositide dependent protein kinase-1 (PDPK1/PDK1) is reported to phosphorylate this kinase, which may mediate insulin signals to the actin cytoskeleton. The proteolytic activation of this kinase by caspase-3 or related proteases during apoptosis suggests its role in signal transduction related to apoptosis. Alternatively spliced transcript variants encoding distinct isoforms have been observed. |
PKN1 Polyclonal Antibody |
|||
BT-AP13130-50ul | Jiaxing Korain Biotech Ltd (BT Labs) | 50ul | Ask for price |
Description: The protein encoded by this gene belongs to the protein kinase C superfamily. This kinase is activated by Rho family of small G proteins and may mediate the Rho-dependent signaling pathway. This kinase can be activated by phospholipids and by limited proteolysis. The 3-phosphoinositide dependent protein kinase-1 (PDPK1/PDK1) is reported to phosphorylate this kinase, which may mediate insulin signals to the actin cytoskeleton. The proteolytic activation of this kinase by caspase-3 or related proteases during apoptosis suggests its role in signal transduction related to apoptosis. Alternatively spliced transcript variants encoding distinct isoforms have been observed. |
PKN1 polyclonal antibody |
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BS5859 | Bioworld Biotech | 50ul | EUR 275 |
Description: Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2 |
PKN1 polyclonal antibody |
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BS74275 | Bioworld Biotech | 50ul | EUR 358 |
Description: 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2 |
PKN1 Polyclonal Antibody |
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E11-200043 | EnoGene | 100ug/100ul | EUR 225 |
Description: Available in various conjugation types. |
PKN1 Polyclonal Antibody |
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E90553a | EnoGene | 100ul | EUR 225 |
Description: Available in various conjugation types. |
PKN1 Polyclonal Antibody |
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JOT-AP13130-100ul | Jotbody | 100ul | EUR 220 |
PKN1 Polyclonal Antibody |
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JOT-AP13130-50ul | Jotbody | 50ul | EUR 144 |
PKN1 Polyclonal Antibody |
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E44H07650 | EnoGene | 100ul | EUR 255 |
Description: Biotin-Conjugated, FITC-Conjugated , AF350 Conjugated , AF405M-Conjugated ,AF488-Conjugated, AF514-Conjugated ,AF532-Conjugated, AF555-Conjugated ,AF568-Conjugated , HRP-Conjugated, AF405S-Conjugated, AF405L-Conjugated , AF546-Conjugated, AF594-Conjugated , AF610-Conjugated, AF635-Conjugated , AF647-Conjugated , AF680-Conjugated , AF700-Conjugated , AF750-Conjugated , AF790-Conjugated , APC-Conjugated , PE-Conjugated , Cy3-Conjugated , Cy5-Conjugated , Cy5.5-Conjugated , Cy7-Conjugated Antibody |
PKN1 monoclonal antibody |
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MB11431 | Bioworld Biotech | 50ul | EUR 398 |
Description: 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40% Glycerol, 0.01% Sodium azide and 0.05% BSA |
PKN1 Polyclonal Antibody |
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MBS8529385-01mg | MyBiosource | 0.1mg | EUR 305 |
PKN1 Polyclonal Antibody |
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MBS8529385-01mLAF405L | MyBiosource | 0.1mL(AF405L) | EUR 465 |
PKN1 Polyclonal Antibody |
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MBS8529385-01mLAF405S | MyBiosource | 0.1mL(AF405S) | EUR 465 |
PKN1 Polyclonal Antibody |
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MBS8529385-01mLAF610 | MyBiosource | 0.1mL(AF610) | EUR 465 |
PKN1 Polyclonal Antibody |
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MBS8529385-01mLAF635 | MyBiosource | 0.1mL(AF635) | EUR 465 |
PKN1 Conjugated Antibody |
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MBS9456359-01mLAF350 | MyBiosource | 0.1mL(AF350) | EUR 480 |
PKN1 Conjugated Antibody |
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MBS9456359-01mLAF405 | MyBiosource | 0.1mL(AF405) | EUR 480 |
PKN1 Conjugated Antibody |
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MBS9456359-01mLAF488 | MyBiosource | 0.1mL(AF488) | EUR 480 |
PKN1 Conjugated Antibody |
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MBS9456359-01mLAF555 | MyBiosource | 0.1mL(AF555) | EUR 480 |
PKN1 Conjugated Antibody |
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MBS9456359-01mLBiotin | MyBiosource | 0.1mL(Biotin) | EUR 480 |
PKN1 Polyclonal Antibody |
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MBS8578652-01mL | MyBiosource | 0.1mL | EUR 305 |
PKN1 Polyclonal Antibody |
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MBS8578652-01mLAF405L | MyBiosource | 0.1mL(AF405L) | EUR 565 |
PKN1 Polyclonal Antibody |
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MBS8578652-01mLAF405S | MyBiosource | 0.1mL(AF405S) | EUR 565 |
PKN1 Polyclonal Antibody |
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MBS8578652-01mLAF610 | MyBiosource | 0.1mL(AF610) | EUR 565 |
PKN1 Polyclonal Antibody |
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MBS8578652-01mLAF635 | MyBiosource | 0.1mL(AF635) | EUR 565 |
PKN1 Antibody (C-Term) |
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E45R33521G-1 | EnoGene | 100 ul | EUR 395 |
PKN1 Antibody (C-Term) |
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E45R33521G-4 | EnoGene | 50 ul | EUR 295 |
PKN1 Antibody (C-Term) |
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MBS9231043-005mL | MyBiosource | 0.05mL | EUR 210 |
PKN1 Antibody (C-Term) |
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MBS9231043-02mL | MyBiosource | 0.2mL | EUR 430 |
PKN1 Antibody (C-Term) |
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MBS9231043-5x02mL | MyBiosource | 5x0.2mL | EUR 1910 |
PKN1 Antibody (C-Terminal) |
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F53997-005ML | NSJ Bioreagents | 0.05 ml | EUR 165 |