Protein misfolded oligomers from cell membranes and abrogates their cytotoxicity

choleratox

Trodusquemine displaces protein misfolded oligomers from cell membranes and abrogates their cytotoxicity through a generic mechanism

 

The onset and progression of numerous protein misfolding diseases are associated with the presence of oligomers formed during the aberrant aggregation of several different proteins, including amyloid-β (Aβ) in Alzheimer’s disease and α-synuclein (αS) in Parkinson’s disease.
These small, soluble aggregates are currently major targets for drug discovery. In this study, we show that trodusquemine, a naturally-occurring aminosterol, markedly reduces the cytotoxicity of αS, Aβ and HypF-N oligomers to human neuroblastoma cells by displacing the oligomers from cell membranes in the absence of any substantial morphological and structural changes to the oligomers.
These results indicate that the reduced toxicity results from a mechanism that is common to oligomers from different proteins, shed light on the origin of the toxicity of the most deleterious species associated with protein aggregation and suggest that aminosterols have the therapeutically-relevant potential to protect cells from the oligomer-induced cytotoxicity associated with numerous protein misfolding diseases.

Comparing supermarket loyalty card data with traditional diet survey data for understanding how protein is purchased and consumed in older adults for the UK, 2014-16

Background: Our ability to understand population-level dietary intake patterns is dependent on having access to high quality data. Diet surveys are common diet assessment methods, but can be limited by bias associated with under-reporting.
Food purchases tracked using supermarket loyalty card records may supplement traditional surveys, however they are rarely available to academics and policy makers. The aim of our study is to explore population level patterns of protein purchasing and consumption in ageing adults (40 years onwards).
Methods: We used diet survey data from the National Diet and Nutrition Survey (2014-16) on food consumption, and loyalty card records on food purchases from a major high street supermarket retailer (2016-17) covering the UK. We computed the percentage of total energy derived from protein, protein intake per kg of body mass, and percentage of protein acquired by food type.
Results: We found that protein consumption (as the percentage of total energy purchased) increased between ages 40-65 years, and declined thereafter. In comparison, protein purchased in supermarkets was roughly 2-2.5 percentage points lower at each year of age.
The proportion of adults meeting recommended levels of protein was lowest in age groups 55-69 and 70+. The time of protein consumption was skewed towards evening meals, with low intakes during breakfast or between main meals. Meat, fish and poultry dominated as sources of protein purchased and consumed, although adults also acquired a large share of their protein from dairy and bread, with little from plant protein.
Conclusions: Our study provides novel insights into how protein is purchased and consumed by ageing adults in the UK. Supermarket loyalty card data can reveal patterns of protein purchasing that when combined with traditional sources of dietary intake may enhance our understanding of dietary behaviors.
Keywords: Big data; Diet surveys; Population; Protein; Supermarket loyalty cards.
choleratox

choleratox

Recombinant EBV EBNA1 Protein, His, E.coli-100ug

QP11731-100ug 100ug
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QP11731-500ug 500ug
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EBV EBNA1 antibody

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Recombinant EBV EBNA1 Mosaic Protein, His, E.coli-1mg

QP11732-1mg 1mg
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EBNA1 Binding Protein 2 Protein

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EBNA1 Binding Protein 2 (EBNA1BP2) Antibody

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EBNA1 Binding Protein 2 (EBNA1BP2) Antibody

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EBNA1BP2 EBNA1 Binding Protein 2 Human Recombinant Protein

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Recombinant EBNA1 Protein [His] (1.185 mg/mL)

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Recombinant EBNA1 Protein [His] (1.25 mg/mL)

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Recombinant (E.Coli, GST tag) Epstein-Barr Virus (EBV/HHV-4) Mosaic EBNA1

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Epstein-Barr Virus (HHV-4) EBNA1 Protein

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Human EBNA1 Binding Protein 2 (EBNA1BP2) ELISA Kit

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EBNA1 Binding Protein 2 Human Recombinant

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Epstein-Barr Virus (HHV-4) Mosaic EBNA1 Protein

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abx061529-1mg 1 mg
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Epstein-Barr Virus (EBV) Epstein-Bar Nuclear Antigen-1 (EBNA-1) Protein

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pCXWB- EBNA1

PVT10196 2 ug
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EBNA1BP2 (untagged)-Human EBNA1 binding protein 2 (EBNA1BP2) transcript variant 1

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Description: The EBVEBNA-1 IgG Antibody ELISA Test Kit has been designed for the the detectionand the quantitative determination of specific IgG antibodies against EBVEBNA-1 in serum and plasma.

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EBNA1BP2 (GFP-tagged) - Human EBNA1 binding protein 2 (EBNA1BP2), transcript variant 2

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Lenti ORF clone of Ebna1bp2 (mGFP-tagged) - Mouse EBNA1 binding protein 2 (Ebna1bp2)

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EBNA1BP2 (Myc-DDK-tagged)-Human EBNA1 binding protein 2 (EBNA1BP2), transcript variant 1

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EBNA1 binding protein 2 (EBNA1BP2) (C-term) rabbit polyclonal antibody, Aff - Purified

AP51355PU-N 400 µl Ask for price

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PVT7175 2 ug
EUR 319.2

Lenti ORF clone of Ebna1bp2 (mGFP-tagged ORF) - Rat EBNA1 binding protein 2 (Ebna1bp2), (10 ug)

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Lenti ORF particles, Ebna1bp2 (GFP-tagged) - Mouse EBNA1 binding protein 2 (Ebna1bp2), 200ul, >10^7 TU/mL

MR204306L4V 200 µl Ask for price

Lenti ORF particles, Ebna1bp2 (GFP-tagged ORF) - Rat EBNA1 binding protein 2 (Ebna1bp2), 200ul, >10^7 TU/mL

RR214064L4V 200 µl Ask for price

Lenti ORF clone of Human EBNA1 binding protein 2 (EBNA1BP2), transcript variant 1, mGFP tagged

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Lenti ORF clone of Human EBNA1 binding protein 2 (EBNA1BP2), transcript variant 2, mGFP tagged

RC200250L2 10 µg Ask for price

The role of monoamine oxidase A in HPV-16 E7-induced epithelial-mesenchymal transition and HIF-1α protein accumulation in non-small cell lung cancer cells

 

Our previous studies have found that human papillomavirus (HPV)-16 E7 oncoprotein promotes epithelial-mesenchymal transition (EMT) and hypoxia-inducible factor-1α (HIF-1α) protein accumulation in non-small cell lung cancer (NSCLC) cells and monoamine oxidase A (MAOA) is highly expressed in NSCLC tissues.
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Furthermore, MAOA knockout suppressed HPV-16 E7-induced ERK1/2 activation. In vivo, MAOA knockout inhibited tumor growth, metastasis, and the expression of EMT-related markers and HIF-1α proteins induced by HPV-16 E7 in NCI-H460 NSCLC subcutaneous xenograft and in situ intrapulmonary models of nude mice. Taken together, our findings provide evidence that MAOA plays a key role in EMT and HIF-1α protein accumulation induced by HPV-16 E7 in NSCLC cells, suggesting that MAOA may be a potential therapeutic target for HPV-related NSCLC.

PKN1 Antibody

DF4790 200ul
EUR 420

PKN1 Antibody

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EUR 280

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EUR 350

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70R-50256 100 ul
EUR 242
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ABD4790 100 ug
EUR 525.6

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EUR 225
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PKN1 Polyclonal Antibody

ABP59926-003ml 0.03ml
EUR 189.6
Description: A polyclonal antibody for detection of PKN1 from Human, Mouse, Rat. This PKN1 antibody is for WB, ELISA. It is affinity-purified from rabbit serum by affinity-chromatography using the specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from part region of human PKN1 protein at amino acid sequence of 720-800

PKN1 Polyclonal Antibody

ABP59926-01ml 0.1ml
EUR 346.8
Description: A polyclonal antibody for detection of PKN1 from Human, Mouse, Rat. This PKN1 antibody is for WB, ELISA. It is affinity-purified from rabbit serum by affinity-chromatography using the specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from part region of human PKN1 protein at amino acid sequence of 720-800

PKN1 Polyclonal Antibody

ABP59926-02ml 0.2ml
EUR 496.8
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PKN1 Polyclonal Antibody

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EUR 255
Description: Biotin-Conjugated, FITC-Conjugated , AF350 Conjugated , AF405M-Conjugated ,AF488-Conjugated, AF514-Conjugated ,AF532-Conjugated, AF555-Conjugated ,AF568-Conjugated , HRP-Conjugated, AF405S-Conjugated, AF405L-Conjugated , AF546-Conjugated, AF594-Conjugated , AF610-Conjugated, AF635-Conjugated , AF647-Conjugated , AF680-Conjugated , AF700-Conjugated , AF750-Conjugated , AF790-Conjugated , APC-Conjugated , PE-Conjugated , Cy3-Conjugated , Cy5-Conjugated , Cy5.5-Conjugated , Cy7-Conjugated Antibody

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F53997-0.05ML 0.05 ml
EUR 140.25
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F53997-0.2ML 0.2 ml
EUR 322.15
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Protein Kinase N1 (PKN1) Antibody

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Protein Kinase N1 (PKN1) Antibody

20-abx008827
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Protein Kinase N1 (PKN1) Antibody

abx135704-01mg 0.1 mg
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PKN1 Rabbit Polyclonal Antibody

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PKN1 Rabbit Monoclonal Antibody

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EUR 275
Description: Biotin-Conjugated, FITC-Conjugated , AF350 Conjugated , AF405M-Conjugated ,AF488-Conjugated, AF514-Conjugated ,AF532-Conjugated, AF555-Conjugated ,AF568-Conjugated , HRP-Conjugated, AF405S-Conjugated, AF405L-Conjugated , AF546-Conjugated, AF594-Conjugated , AF610-Conjugated, AF635-Conjugated , AF647-Conjugated , AF680-Conjugated , AF700-Conjugated , AF750-Conjugated , AF790-Conjugated , APC-Conjugated , PE-Conjugated , Cy3-Conjugated , Cy5-Conjugated , Cy5.5-Conjugated , Cy7-Conjugated Antibody

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E10G34418 100 μl
EUR 275
Description: Biotin-Conjugated, FITC-Conjugated , AF350 Conjugated , AF405M-Conjugated ,AF488-Conjugated, AF514-Conjugated ,AF532-Conjugated, AF555-Conjugated ,AF568-Conjugated , HRP-Conjugated, AF405S-Conjugated, AF405L-Conjugated , AF546-Conjugated, AF594-Conjugated , AF610-Conjugated, AF635-Conjugated , AF647-Conjugated , AF680-Conjugated , AF700-Conjugated , AF750-Conjugated , AF790-Conjugated , APC-Conjugated , PE-Conjugated , Cy3-Conjugated , Cy5-Conjugated , Cy5.5-Conjugated , Cy7-Conjugated Antibody

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E38PA5781 100ul
EUR 225
Description: Available in various conjugation types.

Monoclonal PKN1 Antibody, Clone: 4H10B1

AMM03009G 0.1ml
EUR 633.6
Description: A Monoclonal antibody against Human PKN1. The antibodies are raised in Mouse and are from clone 4H10B1. This antibody is applicable in WB and IHC, FC, ICC, E

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AMM07214G 0.1ml
EUR 633.6
Description: A Monoclonal antibody against Human PKN1. The antibodies are raised in Rabbit and are from clone EPR3238. This antibody is applicable in WB, FC

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SPC-1065D-A565 0.1ml
EUR 480
Description: A polyclonal antibody for PKN1 (pThr774) from Human. The antibody is produced in rabbit after immunization with Human A phospho-specific peptide corresponding to residues surrounding Thr774 of human PKN1 (AA771-777). The Antibody is tested and validated for WB, AM assays with the following recommended dilutions: WB (1:250). This PKN1 (pThr774) antibody is conjugated to ATTO 565.

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SPC-1065D-A633 0.1ml
EUR 480
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Antibody for Human PKN1 (pThr774)

SPC-1065D-A655 0.1ml
EUR 480
Description: A polyclonal antibody for PKN1 (pThr774) from Human. The antibody is produced in rabbit after immunization with Human A phospho-specific peptide corresponding to residues surrounding Thr774 of human PKN1 (AA771-777). The Antibody is tested and validated for WB, AM assays with the following recommended dilutions: WB (1:250). This PKN1 (pThr774) antibody is conjugated to ATTO 655.

Antibody for Human PKN1 (pThr774)

SPC-1065D-A680 0.1ml
EUR 480
Description: A polyclonal antibody for PKN1 (pThr774) from Human. The antibody is produced in rabbit after immunization with Human A phospho-specific peptide corresponding to residues surrounding Thr774 of human PKN1 (AA771-777). The Antibody is tested and validated for WB, AM assays with the following recommended dilutions: WB (1:250). This PKN1 (pThr774) antibody is conjugated to ATTO 680.

Antibody for Human PKN1 (pThr774)

SPC-1065D-A700 0.1ml
EUR 480
Description: A polyclonal antibody for PKN1 (pThr774) from Human. The antibody is produced in rabbit after immunization with Human A phospho-specific peptide corresponding to residues surrounding Thr774 of human PKN1 (AA771-777). The Antibody is tested and validated for WB, AM assays with the following recommended dilutions: WB (1:250). This PKN1 (pThr774) antibody is conjugated to ATTO 700.

Antibody for Human PKN1 (pThr774)

SPC-1065D-ALP 0.1ml
EUR 472.8
Description: A polyclonal antibody for PKN1 (pThr774) from Human. The antibody is produced in rabbit after immunization with Human A phospho-specific peptide corresponding to residues surrounding Thr774 of human PKN1 (AA771-777). The Antibody is tested and validated for WB, AM assays with the following recommended dilutions: WB (1:250). This PKN1 (pThr774) antibody is conjugated to Alkaline Phosphatase.

Antibody for Human PKN1 (pThr774)

SPC-1065D-APC 0.1ml
EUR 478.8
Description: A polyclonal antibody for PKN1 (pThr774) from Human. The antibody is produced in rabbit after immunization with Human A phospho-specific peptide corresponding to residues surrounding Thr774 of human PKN1 (AA771-777). The Antibody is tested and validated for WB, AM assays with the following recommended dilutions: WB (1:250). This PKN1 (pThr774) antibody is conjugated to APC .

Antibody for Human PKN1 (pThr774)

SPC-1065D-APCCY7 0.1ml
EUR 565.2
Description: A polyclonal antibody for PKN1 (pThr774) from Human. The antibody is produced in rabbit after immunization with Human A phospho-specific peptide corresponding to residues surrounding Thr774 of human PKN1 (AA771-777). The Antibody is tested and validated for WB, AM assays with the following recommended dilutions: WB (1:250). This PKN1 (pThr774) antibody is conjugated to APC/Cy7.

Antibody for Human PKN1 (pThr774)

SPC-1065D-DY350 0.1ml
EUR 570
Description: A polyclonal antibody for PKN1 (pThr774) from Human. The antibody is produced in rabbit after immunization with Human A phospho-specific peptide corresponding to residues surrounding Thr774 of human PKN1 (AA771-777). The Antibody is tested and validated for WB, AM assays with the following recommended dilutions: WB (1:250). This PKN1 (pThr774) antibody is conjugated to Dylight 350.

Antibody for Human PKN1 (pThr774)

SPC-1065D-DY405 0.1ml
EUR 542.4
Description: A polyclonal antibody for PKN1 (pThr774) from Human. The antibody is produced in rabbit after immunization with Human A phospho-specific peptide corresponding to residues surrounding Thr774 of human PKN1 (AA771-777). The Antibody is tested and validated for WB, AM assays with the following recommended dilutions: WB (1:250). This PKN1 (pThr774) antibody is conjugated to Dylight 405.

Antibody for Human PKN1 (pThr774)

SPC-1065D-DY488 0.1ml
EUR 518.4
Description: A polyclonal antibody for PKN1 (pThr774) from Human. The antibody is produced in rabbit after immunization with Human A phospho-specific peptide corresponding to residues surrounding Thr774 of human PKN1 (AA771-777). The Antibody is tested and validated for WB, AM assays with the following recommended dilutions: WB (1:250). This PKN1 (pThr774) antibody is conjugated to Dylight 488.

Antibody for Human PKN1 (pThr774)

SPC-1065D-DY594 0.1ml
EUR 523.2
Description: A polyclonal antibody for PKN1 (pThr774) from Human. The antibody is produced in rabbit after immunization with Human A phospho-specific peptide corresponding to residues surrounding Thr774 of human PKN1 (AA771-777). The Antibody is tested and validated for WB, AM assays with the following recommended dilutions: WB (1:250). This PKN1 (pThr774) antibody is conjugated to Dylight 594.

Antibody for Human PKN1 (pThr774)

SPC-1065D-DY633 0.1ml
EUR 511.2
Description: A polyclonal antibody for PKN1 (pThr774) from Human. The antibody is produced in rabbit after immunization with Human A phospho-specific peptide corresponding to residues surrounding Thr774 of human PKN1 (AA771-777). The Antibody is tested and validated for WB, AM assays with the following recommended dilutions: WB (1:250). This PKN1 (pThr774) antibody is conjugated to Dylight 633.

Antibody for Human PKN1 (pThr774)

SPC-1065D-HRP 0.1ml
EUR 465.6
Description: A polyclonal antibody for PKN1 (pThr774) from Human. The antibody is produced in rabbit after immunization with Human A phospho-specific peptide corresponding to residues surrounding Thr774 of human PKN1 (AA771-777). The Antibody is tested and validated for WB, AM assays with the following recommended dilutions: WB (1:250). This PKN1 (pThr774) antibody is conjugated to HRP.

Antibody for Human PKN1 (pThr774)

SPC-1065D-P594 0.1ml
EUR 488.4
Description: A polyclonal antibody for PKN1 (pThr774) from Human. The antibody is produced in rabbit after immunization with Human A phospho-specific peptide corresponding to residues surrounding Thr774 of human PKN1 (AA771-777). The Antibody is tested and validated for WB, AM assays with the following recommended dilutions: WB (1:250). This PKN1 (pThr774) antibody is conjugated to PE/ATTO 594.

Antibody for Human PKN1 (pThr774)

SPC-1065D-PCP 0.1ml
EUR 478.8
Description: A polyclonal antibody for PKN1 (pThr774) from Human. The antibody is produced in rabbit after immunization with Human A phospho-specific peptide corresponding to residues surrounding Thr774 of human PKN1 (AA771-777). The Antibody is tested and validated for WB, AM assays with the following recommended dilutions: WB (1:250). This PKN1 (pThr774) antibody is conjugated to PerCP.

Antibody for Human PKN1 (pThr774)

SPC-1065D-RPE 0.1ml
EUR 476.4
Description: A polyclonal antibody for PKN1 (pThr774) from Human. The antibody is produced in rabbit after immunization with Human A phospho-specific peptide corresponding to residues surrounding Thr774 of human PKN1 (AA771-777). The Antibody is tested and validated for WB, AM assays with the following recommended dilutions: WB (1:250). This PKN1 (pThr774) antibody is conjugated to RPE .

Antibody for Human PKN1 (pThr774)

SPC-1065D-STR 0.1ml
EUR 477.6
Description: A polyclonal antibody for PKN1 (pThr774) from Human. The antibody is produced in rabbit after immunization with Human A phospho-specific peptide corresponding to residues surrounding Thr774 of human PKN1 (AA771-777). The Antibody is tested and validated for WB, AM assays with the following recommended dilutions: WB (1:250). This PKN1 (pThr774) antibody is conjugated to Streptavidin.

Mouse Monoclonal Antibody to PKN1

E10-30717 100ul
EUR 225
Description: Available in various conjugation types.

Mouse Monoclonal Antibody to PKN1

E10-30717T 100ul
EUR 225
Description: Available in various conjugation types.

Mouse Monoclonal Antibody to PKN1

sAP-1066 50ug
EUR 270

Protein Kinase N1 (PKN1) Polyclonal Antibody

CAU27791-100ul 100ul
EUR 211.2

Protein Kinase N1 (PKN1) Polyclonal Antibody

CAU27791-200ul 200ul
EUR 263.8

Serine/Threonine-Protein Kinase N1 (PKN1) Antibody

20-abx327640
  • Ask for price
  • Ask for price
  • 100 ug
  • 50 ug

Serine/Threonine-Protein Kinase N1 (PKN1) Antibody

abx224112-100ug 100 ug
EUR 493.2

Serine/Threonine-Protein Kinase N1 (PKN1) Antibody

abx149738-100ug 100 ug
EUR 526.8

Serine/Threonine-Protein Kinase N1 (PKN1) Antibody

20-abx015170
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  • Ask for price
  • Ask for price
  • Ask for price
  • 100 ug
  • 10 ug
  • 200 ug
  • 300 µg

Serine/Threonine-Protein Kinase N1 (PKN1) Antibody

abx015170-100g 100 µg
EUR 43.75

Serine/Threonine-Protein Kinase N1 (PKN1) Antibody

abx224112-100l 100 µl Ask for price

Serine/Threonine-Protein Kinase N1 (PKN1) Antibody

abx224112-50l 50 µl
EUR 362.5

Serine/Threonine-Protein Kinase N1 (PKN1) Antibody

abx327640-100g 100 µg
EUR 250

Serine/Threonine-Protein Kinase N1 (PKN1) Antibody

abx327640-50g 50 µg
EUR 187.5

ARP54944_P050-25UL - Pkn1 Antibody - C-terminal region

ARP54944_P050-25UL 25ul
EUR 99

ARP54944_P050 - Pkn1 Antibody - C-terminal region (ARP54944_P050)

ARP54944_P050 100ul
EUR 389

Mouse Monoclonal anti-human PKN1

hAP-1071 50ug
EUR 400

Polyclonal Antibody to Protein Kinase N1 (PKN1)

PAA501Hu01 100ul
EUR 220

Protein Kinase N1 (PKN1) Polyclonal Antibody (Human)

4-PAA501Hu01
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  • Ask for price
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  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
Description: A Rabbit polyclonal antibody against Human Protein Kinase N1 (PKN1)
Gregory

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