Trodusquemine displaces protein misfolded oligomers from cell membranes and abrogates their cytotoxicity through a generic mechanism
The onset and progression of numerous protein misfolding diseases are associated with the presence of oligomers formed during the aberrant aggregation of several different proteins, including amyloid-β (Aβ) in Alzheimer’s disease and α-synuclein (αS) in Parkinson’s disease.
These small, soluble aggregates are currently major targets for drug discovery. In this study, we show that trodusquemine, a naturally-occurring aminosterol, markedly reduces the cytotoxicity of αS, Aβ and HypF-N oligomers to human neuroblastoma cells by displacing the oligomers from cell membranes in the absence of any substantial morphological and structural changes to the oligomers.
These results indicate that the reduced toxicity results from a mechanism that is common to oligomers from different proteins, shed light on the origin of the toxicity of the most deleterious species associated with protein aggregation and suggest that aminosterols have the therapeutically-relevant potential to protect cells from the oligomer-induced cytotoxicity associated with numerous protein misfolding diseases.
Comparing supermarket loyalty card data with traditional diet survey data for understanding how protein is purchased and consumed in older adults for the UK, 2014-16
Background: Our ability to understand population-level dietary intake patterns is dependent on having access to high quality data. Diet surveys are common diet assessment methods, but can be limited by bias associated with under-reporting.
Food purchases tracked using supermarket loyalty card records may supplement traditional surveys, however they are rarely available to academics and policy makers. The aim of our study is to explore population level patterns of protein purchasing and consumption in ageing adults (40 years onwards).
Methods: We used diet survey data from the National Diet and Nutrition Survey (2014-16) on food consumption, and loyalty card records on food purchases from a major high street supermarket retailer (2016-17) covering the UK. We computed the percentage of total energy derived from protein, protein intake per kg of body mass, and percentage of protein acquired by food type.
Results: We found that protein consumption (as the percentage of total energy purchased) increased between ages 40-65 years, and declined thereafter. In comparison, protein purchased in supermarkets was roughly 2-2.5 percentage points lower at each year of age.
The proportion of adults meeting recommended levels of protein was lowest in age groups 55-69 and 70+. The time of protein consumption was skewed towards evening meals, with low intakes during breakfast or between main meals. Meat, fish and poultry dominated as sources of protein purchased and consumed, although adults also acquired a large share of their protein from dairy and bread, with little from plant protein.
Conclusions: Our study provides novel insights into how protein is purchased and consumed by ageing adults in the UK. Supermarket loyalty card data can reveal patterns of protein purchasing that when combined with traditional sources of dietary intake may enhance our understanding of dietary behaviors.
Keywords: Big data; Diet surveys; Population; Protein; Supermarket loyalty cards.
Recombinant EBV EBNA1 Protein, His, E.coli-100ug |
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QP11731-100ug | EnQuireBio | 100ug | EUR 381.6 |
Recombinant EBV EBNA1 Protein, His, E.coli-500ug |
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QP11731-500ug | EnQuireBio | 500ug | EUR 1034.4 |
EBV EBNA1 antibody |
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20-EG46 | Fitzgerald | 1 mg | EUR 90 |
Description: Goat polyclonal EBV EBNA1 antibody |
Recombinant EBV EBNA1 Mosaic Protein, His, E.coli-1mg |
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QP11732-1mg | EnQuireBio | 1mg | EUR 1273.2 |
Recombinant EBV EBNA1 Mosaic Protein, His, E.coli-100ug |
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QP11732-100ug | EnQuireBio | 100ug | EUR 261.6 |
Recombinant EBV EBNA1 Mosaic Protein, His, E.coli-500ug |
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QP11732-500ug | EnQuireBio | 500ug | EUR 795.6 |
Recombinant EBV EBNA1 Mosaic Protein (aa 1-90 & 408-498) [His] |
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VAng-2528Lsx-100g | Creative Biolabs | 100 µg | EUR 555.6 |
Description: EBV EBNA1 Mosaic protein, His tag at C-terminus, recombinant protein from E. coli. |
Recombinant EBV EBNA1 Mosaic Protein (aa 1-90 & 408-498) [His] |
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VAng-2528Lsx-1mg | Creative Biolabs | 1 mg | EUR 3360 |
Description: EBV EBNA1 Mosaic protein, His tag at C-terminus, recombinant protein from E. coli. |
Recombinant EBV EBNA1 Mosaic Protein (aa 1-90 & 408-498) [His] |
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VAng-2528Lsx-500g | Creative Biolabs | 500 µg | EUR 2040 |
Description: EBV EBNA1 Mosaic protein, His tag at C-terminus, recombinant protein from E. coli. |
Recombinant EBV EBNA1 Mosaic Protein (aa 1-90 & 408-498) [GST] |
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VAng-Lsx0111-100g | Creative Biolabs | 100 µg | EUR 759.6 |
Description: EBV EBNA1 Mosaic protein [GST], recombinant protein from E. coli. |
Recombinant EBV EBNA1 Mosaic Protein (aa 1-90 & 408-498) [GST] |
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VAng-Lsx0111-500g | Creative Biolabs | 500 µg | EUR 2419.2 |
Description: EBV EBNA1 Mosaic protein [GST], recombinant protein from E. coli. |
EBV Nuclear Antigen EBNA1. p72 (stabilized) |
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BA1362R01 | Serion Immundiagnostica GmbH | 29 mg | EUR 715 |
EBV EBNA protein |
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30-AE46 | Fitzgerald | 200 ug | EUR 667 |
Description: Purified recombinant EBV EBNA protein |
EBNA1 protein |
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30-1925 | Fitzgerald | 500 ug | EUR 495 |
Description: Purified Recombinant EBNA1 protein |
EBNA1 protein (His tag) |
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80-1340 | Fitzgerald | 100 ug | EUR 233 |
Description: Purified recombinant EBNA1 protein (His tag) |
Recombinant EBNA1 Protein [GST] |
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VAng-Lsx0122-100g | Creative Biolabs | 100 µg | EUR 818.4 |
Description: EBNA1 (EBV) (P03211) partial recombinant protein with GST tag expressed in E. coli. |
EBNA1 Binding Protein 2 Protein |
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20-abx260778 | Abbexa |
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EBNA1 Binding Protein 2 Protein |
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abx260778-10g | Abbexa | 10 µg | EUR 325 |
EBNA1 Binding Protein 2 Protein |
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abx260778-2g | Abbexa | 2 µg | EUR 225 |
EBNA1 Binding Protein 2 (EBNA1BP2) Antibody |
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20-abx123650 | Abbexa |
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EBNA1 Binding Protein 2 (EBNA1BP2) Antibody |
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abx026949-400ul | Abbexa | 400 ul | EUR 627.6 |
EBNA1 Binding Protein 2 (EBNA1BP2) Antibody |
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abx026949-80l | Abbexa | 80 µl | EUR 343.2 |
EBNA1 Binding Protein 2 (EBNA1BP2) Antibody |
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abx123650-100l | Abbexa | 100 µl | EUR 175 |
EBNA1 Binding Protein 2 (EBNA1BP2) Antibody |
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abx123650-1ml | Abbexa | 1 ml | EUR 400 |
EBNA1 Binding Protein 2 (EBNA1BP2) Antibody |
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abx123650-200l | Abbexa | 200 µl | EUR 275 |
EBNA1 Binding Protein 2 (EBNA1BP2) Antibody |
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abx026949-400l | Abbexa | 400 µl | EUR 518.75 |
EBNA1BP2 EBNA1 Binding Protein 2 Human Recombinant Protein |
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PROTQ99848 | BosterBio | Regular: 20ug | EUR 380.4 |
Description: Recombinant Human EBNA1BP2 produced in E. coli is a single polypeptide chain containing 329 amino acids (1-306) and having a molecular mass of 37.2kDa.;EBNA1BP2 is fused to a 23 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques. |
Recombinant EBNA1 Protein [His] (1.185 mg/mL) |
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VAng-0610Lsx-inquire | Creative Biolabs | inquire | Ask for price |
Description: Epstein-Barr Virus (EBV) Nuclear Antigen-1 (EBNA-1), recombinant protein from E. coli. MW 63 kDa, 1.185 mg/mL. |
Recombinant EBNA1 Protein [His] (1.25 mg/mL) |
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VAng-0611Lsx-inquire | Creative Biolabs | inquire | Ask for price |
Description: Epstein-Barr Virus (EBV) Nuclear Antigen-1 (EBNA-1), recombinant protein from E. coli. MW 63 kDa, 1.25 mg/mL. |
Recombinant (E.Coli, GST tag) Epstein-Barr Virus (EBV/HHV-4) Mosaic EBNA1 |
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RP-347 | Alpha Diagnostics | 100 ug | EUR 343.2 |
Epstein-Barr Virus (HHV-4) EBNA1 Protein |
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20-abx260340 | Abbexa |
|
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Human EBNA1 Binding Protein 2 (EBNA1BP2) ELISA Kit |
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abx384822-96tests | Abbexa | 96 tests | EUR 1093.2 |
Mouse EBNA1 Binding Protein 2 (EBNA1BP2) ELISA Kit |
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abx389130-96tests | Abbexa | 96 tests | EUR 1093.2 |
EBNA1 Binding Protein 2 Human Recombinant |
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rAP-5190 | Angio Proteomie | Inquiry | Ask for price |
Ebna1bp2 (GFP-tagged) - Mouse EBNA1 binding protein 2 (Ebna1bp2) |
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MG204306 | Origene Technologies GmbH | 10 µg | Ask for price |
Ebna1bp2 (untagged) - Mouse EBNA1 binding protein 2 (Ebna1bp2), (10ug) |
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MC202488 | Origene Technologies GmbH | 10 µg | Ask for price |
Recombinant EBNA1 Protein (aa 1-90, 408-498) [GST] |
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VAng-Lsx0128-inquire | Creative Biolabs | inquire | Ask for price |
Description: EBV NA1 (aa 1-90, 408-498) [GST], recombinant protein from E. coli. |
Epstein-Barr Virus (HHV-4) Mosaic EBNA1 Protein |
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20-abx260113 | Abbexa |
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Epstein-Barr Virus (HHV-4) Mosaic EBNA1 Protein |
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abx260113-10g | Abbexa | 10 µg | EUR 950 |
Epstein-Barr Virus (HHV-4) Mosaic EBNA1 Protein |
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abx260113-2g | Abbexa | 2 µg | EUR 350 |
Ebna1bp2 (Myc-DDK-tagged) - Mouse EBNA1 binding protein 2 (Ebna1bp2) |
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MR204306 | Origene Technologies GmbH | 10 µg | Ask for price |
EBV EBNA-3A 38 kDa |
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PR-1446-L | Jena Bioscience GmbH | 1mg | EUR 1307.3 |
Description: recombinant, E. coli |
EBV EBNA-3A 38 kDa |
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PR-1446-S | Jena Bioscience GmbH | 200µg | EUR 326.7 |
Description: recombinant, E. coli |
EBV EBNA-1 IgG ELISA |
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GWB-5B1487 | GenWay Biotech | ELISA_Kits | Ask for price |
EBV EBNA-1 IgM ELISA |
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GWB-7189DB | GenWay Biotech | ELISA_Kits | Ask for price |
EBV EBNA-1 IgA ELISA |
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GWB-BA4BE2 | GenWay Biotech | ELISA_Kits | Ask for price |
Ebna1bp2 (untagged ORF) - Rat EBNA1 binding protein 2 (Ebna1bp2), (10 ug) |
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RN214064 | Origene Technologies GmbH | 10 µg | Ask for price |
Epstein-Barr Virus (EBV) Epstein-Bar Nuclear Antigen-1 (EBNA-1) Protein |
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abx061529-1mg | Abbexa | 1 mg | EUR 2030.4 |
Epstein-Barr Virus (EBV) Epstein-Bar Nuclear Antigen-1 (EBNA-1) Protein |
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abx061529-100g | Abbexa | 100 µg | Ask for price |
Epstein-Barr Virus (EBV) Epstein-Bar Nuclear Antigen-1 (EBNA-1) Protein |
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abx061529-10g | Abbexa | 10 µg | EUR 2150 |
Epstein-Barr Virus (EBV) Epstein-Bar Nuclear Antigen-1 (EBNA-1) Protein |
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abx061529-50g | Abbexa | 50 µg | Ask for price |
pCXWB- EBNA1 |
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PVT10196 | Lifescience Market | 2 ug | EUR 361.2 |
EBNA1BP2 (untagged)-Human EBNA1 binding protein 2 (EBNA1BP2) transcript variant 1 |
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SC326927 | Origene Technologies GmbH | 10 µg | Ask for price |
EBNA1BP2 (untagged)-Human EBNA1 binding protein 2 (EBNA1BP2), transcript variant 2 |
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SC320280 | Origene Technologies GmbH | 10 µg | Ask for price |
EBV EBNA-1 IgG ELISA Kit |
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DEIA332 | Creative Diagnostics | 96T | EUR 618 |
Description: The EBVEBNA-1 IgG Antibody ELISA Test Kit has been designed for the the detectionand the quantitative determination of specific IgG antibodies against EBVEBNA-1 in serum and plasma. |
EBV EBNA-1 IgA ELISA Kit |
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DEIA333 | Creative Diagnostics | 96T | EUR 618 |
Description: The EBVEBNA-1 IgA Antibody ELISA Test Kit has been designed for the the detectionand the quantitative determination of specific IgA antibodies against EBVEBNA-1 in serum and plasma. |
EBV EBNA-1 IgM ELISA Kit |
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DEIA334 | Creative Diagnostics | 96T | EUR 618 |
Description: The EBVEBNA-1 IgM Antibody ELISA Test Kit has been designed for the the detectionand the quantitative determination of specific IgM antibodies against EBVEBNA-1 in serum and plasma. |
EBV EBNA-1 mosaic 45 kDa |
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PR-1447-L | Jena Bioscience GmbH | 1mg | EUR 1958.7 |
Description: recombinant, E. coli |
EBV EBNA-1 mosaic 45 kDa |
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PR-1447-S | Jena Bioscience GmbH | 200µg | EUR 489.8 |
Description: recombinant, E. coli |
Ebna1bp2 (Myc-DDK-tagged ORF) - Rat EBNA1 binding protein 2 (Ebna1bp2), (10 ug) |
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RR214064 | Origene Technologies GmbH | 10 µg | Ask for price |
EBNA1BP2 (GFP-tagged) - Human EBNA1 binding protein 2 (EBNA1BP2), transcript variant 2 |
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RG200250 | Origene Technologies GmbH | 10 µg | Ask for price |
EBNA1BP2 (GFP-tagged) - Human EBNA1 binding protein 2 (EBNA1BP2), transcript variant 1 |
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RG228292 | Origene Technologies GmbH | 10 µg | Ask for price |
Lenti ORF clone of Ebna1bp2 (mGFP-tagged) - Mouse EBNA1 binding protein 2 (Ebna1bp2) |
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MR204306L4 | Origene Technologies GmbH | 10 µg | Ask for price |
EBNA1BP2 (Myc-DDK-tagged)-Human EBNA1 binding protein 2 (EBNA1BP2), transcript variant 1 |
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RC228292 | Origene Technologies GmbH | 10 µg | Ask for price |
EBNA1BP2 (Myc-DDK-tagged)-Human EBNA1 binding protein 2 (EBNA1BP2), transcript variant 2 |
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RC200250 | Origene Technologies GmbH | 10 µg | Ask for price |
Lenti ORF clone of Ebna1bp2 (Myc-DDK-tagged) - Mouse EBNA1 binding protein 2 (Ebna1bp2) |
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MR204306L3 | Origene Technologies GmbH | 10 µg | Ask for price |
EBV antigen EBNA-1 Antibody |
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abx140258-01mg | Abbexa | 0.1 mg | EUR 393.6 |
EBV antigen EBNA-1 Antibody |
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abx140258-100g | Abbexa | 100 µg | EUR 250 |
EBNA1-IN-SC7 |
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T62921-10mg | TargetMol Chemicals | 10mg | Ask for price |
Description: EBNA1-IN-SC7 |
EBNA1-IN-SC7 |
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T62921-1g | TargetMol Chemicals | 1g | Ask for price |
Description: EBNA1-IN-SC7 |
EBNA1-IN-SC7 |
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T62921-1mg | TargetMol Chemicals | 1mg | Ask for price |
Description: EBNA1-IN-SC7 |
EBNA1-IN-SC7 |
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T62921-50mg | TargetMol Chemicals | 50mg | Ask for price |
Description: EBNA1-IN-SC7 |
EBNA1-IN-SC7 |
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T62921-5mg | TargetMol Chemicals | 5mg | Ask for price |
Description: EBNA1-IN-SC7 |
EBNA1 binding protein 2 (EBNA1BP2) (C-term) rabbit polyclonal antibody, Aff - Purified |
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AP51355PU-N | Origene Technologies GmbH | 400 µl | Ask for price |
pCXWB- EBNA1 Plasmid |
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PVT7175 | Lifescience Market | 2 ug | EUR 319.2 |
Lenti ORF clone of Ebna1bp2 (mGFP-tagged ORF) - Rat EBNA1 binding protein 2 (Ebna1bp2), (10 ug) |
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RR214064L4 | Origene Technologies GmbH | 10 µg | Ask for price |
Lenti ORF clone of Ebna1bp2 (Myc-DDK-tagged ORF) - Rat EBNA1 binding protein 2 (Ebna1bp2), (10 ug) |
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RR214064L3 | Origene Technologies GmbH | 10 µg | Ask for price |
Lenti ORF particles, Ebna1bp2 (GFP-tagged) - Mouse EBNA1 binding protein 2 (Ebna1bp2), 200ul, >10^7 TU/mL |
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MR204306L4V | Origene Technologies GmbH | 200 µl | Ask for price |
Lenti ORF particles, Ebna1bp2 (GFP-tagged ORF) - Rat EBNA1 binding protein 2 (Ebna1bp2), 200ul, >10^7 TU/mL |
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RR214064L4V | Origene Technologies GmbH | 200 µl | Ask for price |
Lenti ORF clone of Human EBNA1 binding protein 2 (EBNA1BP2), transcript variant 1, mGFP tagged |
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RC228292L4 | Origene Technologies GmbH | 10 µg | Ask for price |
Lenti ORF clone of Human EBNA1 binding protein 2 (EBNA1BP2), transcript variant 2, mGFP tagged |
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RC200250L2 | Origene Technologies GmbH | 10 µg | Ask for price |
The role of monoamine oxidase A in HPV-16 E7-induced epithelial-mesenchymal transition and HIF-1α protein accumulation in non-small cell lung cancer cells
Our previous studies have found that human papillomavirus (HPV)-16 E7 oncoprotein promotes epithelial-mesenchymal transition (EMT) and hypoxia-inducible factor-1α (HIF-1α) protein accumulation in non-small cell lung cancer (NSCLC) cells and monoamine oxidase A (MAOA) is highly expressed in NSCLC tissues.
Here, we further explored the role of MAOA in HPV-16 E7-induced EMT and HIF-1α protein accumulation in A549 and NCI-H460 NSCLC cells. Our results showed that HPV-16 E7 enhanced MAOA expression in NSCLC cells. Additionally, MAOA knockout inhibited HPV-16 E7-induced migration, invasion, and EMT, and significantly reduced HPV-16 E7-induced ROS generation and HIF-1α protein accumulation via promoting its degradation.
Furthermore, MAOA knockout suppressed HPV-16 E7-induced ERK1/2 activation. In vivo, MAOA knockout inhibited tumor growth, metastasis, and the expression of EMT-related markers and HIF-1α proteins induced by HPV-16 E7 in NCI-H460 NSCLC subcutaneous xenograft and in situ intrapulmonary models of nude mice. Taken together, our findings provide evidence that MAOA plays a key role in EMT and HIF-1α protein accumulation induced by HPV-16 E7 in NSCLC cells, suggesting that MAOA may be a potential therapeutic target for HPV-related NSCLC.
PKN1 Antibody |
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DF4790 | Affbiotech | 200ul | EUR 420 |
PKN1 Antibody |
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DF4790-100ul | Affinity Biosciences | 100ul | EUR 280 |
PKN1 Antibody |
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DF4790-200ul | Affinity Biosciences | 200ul | EUR 350 |
PKN1 antibody |
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70R-50256 | Fitzgerald | 100 ul | EUR 242 |
Description: Purified Polyclonal PKN1 antibody |
PKN1 Antibody |
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ABD4790 | Lifescience Market | 100 ug | EUR 525.6 |
PKN1/PRK1 Antibody |
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35295 | SAB | 100ul | EUR 319 |
PKN1/PRK1 Antibody |
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35295-100ul | SAB | 100ul | EUR 302.4 |
PKN1/PRK1 Antibody |
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35295-50ul | SAB | 50ul | EUR 224.4 |
PKN1/PRK1 Antibody |
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E035295 | EnoGene | 100μg/100μl | EUR 225 |
Description: Available in various conjugation types. |
PKN1 Polyclonal Antibody |
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E11-200043 | EnoGene | 100ug/100ul | EUR 225 |
Description: Available in various conjugation types. |
PKN1 Polyclonal Antibody |
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E90553a | EnoGene | 100ul | EUR 225 |
Description: Available in various conjugation types. |
PKN1 Conjugated Antibody |
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C48392 | SAB | 100ul | EUR 476.4 |
PKN1 Polyclonal Antibody |
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ABP59926-003ml | Abbkine | 0.03ml | EUR 189.6 |
Description: A polyclonal antibody for detection of PKN1 from Human, Mouse, Rat. This PKN1 antibody is for WB, ELISA. It is affinity-purified from rabbit serum by affinity-chromatography using the specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from part region of human PKN1 protein at amino acid sequence of 720-800 |
PKN1 Polyclonal Antibody |
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ABP59926-01ml | Abbkine | 0.1ml | EUR 346.8 |
Description: A polyclonal antibody for detection of PKN1 from Human, Mouse, Rat. This PKN1 antibody is for WB, ELISA. It is affinity-purified from rabbit serum by affinity-chromatography using the specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from part region of human PKN1 protein at amino acid sequence of 720-800 |
PKN1 Polyclonal Antibody |
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ABP59926-02ml | Abbkine | 0.2ml | EUR 496.8 |
Description: A polyclonal antibody for detection of PKN1 from Human, Mouse, Rat. This PKN1 antibody is for WB, ELISA. It is affinity-purified from rabbit serum by affinity-chromatography using the specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from part region of human PKN1 protein at amino acid sequence of 720-800 |
PKN1 Polyclonal Antibody |
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E44H07650 | EnoGene | 100ul | EUR 255 |
Description: Biotin-Conjugated, FITC-Conjugated , AF350 Conjugated , AF405M-Conjugated ,AF488-Conjugated, AF514-Conjugated ,AF532-Conjugated, AF555-Conjugated ,AF568-Conjugated , HRP-Conjugated, AF405S-Conjugated, AF405L-Conjugated , AF546-Conjugated, AF594-Conjugated , AF610-Conjugated, AF635-Conjugated , AF647-Conjugated , AF680-Conjugated , AF700-Conjugated , AF750-Conjugated , AF790-Conjugated , APC-Conjugated , PE-Conjugated , Cy3-Conjugated , Cy5-Conjugated , Cy5.5-Conjugated , Cy7-Conjugated Antibody |
PKN1 Antibody (C-Terminal) |
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F53997-0.05ML | NSJ Bioreagents | 0.05 ml | EUR 140.25 |
Description: PKC-related serine/threonine-protein kinase involved in various processes such as regulation of the intermediate filaments of the actin cytoskeleton, cell migration, tumor cell invasion and transcription regulation. Regulates the cytoskeletal network by phosphorylating proteins such as VIM and neurofilament proteins NEFH, NEFL and NEFM, leading to inhibit their polymerization. Phosphorylates 'Ser-575', 'Ser-637' and 'Ser-669' of MAPT/Tau, lowering its ability to bind to microtubules, resulting in disruption of tubulin assembly. Acts as a key coactivator of androgen receptor (ANDR)-dependent transcription, by being recruited to ANDR target genes and specifically mediating phosphorylation of 'Thr-11' of histone H3 (H3T11ph), a specific tag for epigenetic transcriptional activation that promotes demethylation of histone H3 'Lys-9' (H3K9me) by KDM4C/JMJD2C. Phosphorylates HDAC5, HDAC7 and HDAC9, leading to impair their import in the nucleus. Phosphorylates 'Thr-38' of PPP1R14A, 'Ser- 159', 'Ser-163' and 'Ser-170' of MARCKS, and GFAP. Able to phosphorylate RPS6 in vitro. |
PKN1 Antibody (C-Terminal) |
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F53997-0.2ML | NSJ Bioreagents | 0.2 ml | EUR 322.15 |
Description: PKC-related serine/threonine-protein kinase involved in various processes such as regulation of the intermediate filaments of the actin cytoskeleton, cell migration, tumor cell invasion and transcription regulation. Regulates the cytoskeletal network by phosphorylating proteins such as VIM and neurofilament proteins NEFH, NEFL and NEFM, leading to inhibit their polymerization. Phosphorylates 'Ser-575', 'Ser-637' and 'Ser-669' of MAPT/Tau, lowering its ability to bind to microtubules, resulting in disruption of tubulin assembly. Acts as a key coactivator of androgen receptor (ANDR)-dependent transcription, by being recruited to ANDR target genes and specifically mediating phosphorylation of 'Thr-11' of histone H3 (H3T11ph), a specific tag for epigenetic transcriptional activation that promotes demethylation of histone H3 'Lys-9' (H3K9me) by KDM4C/JMJD2C. Phosphorylates HDAC5, HDAC7 and HDAC9, leading to impair their import in the nucleus. Phosphorylates 'Thr-38' of PPP1R14A, 'Ser- 159', 'Ser-163' and 'Ser-170' of MARCKS, and GFAP. Able to phosphorylate RPS6 in vitro. |
PKN1 Antibody (C-Terminal) |
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F53997-005ML | NSJ Bioreagents | 0.05 ml | EUR 165 |
OACD06544-1ML - PKN1 Antibody |
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OACD06544-1ML | Aviva Systems Biology | 1ml | EUR 599 |
OAAL00258-100UG - PKN1 Antibody |
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OAAL00258-100UG | Aviva Systems Biology | 100ug | EUR 349 |
OACD06544-100UL - PKN1 Antibody |
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OACD06544-100UL | Aviva Systems Biology | 100ul | EUR 179 |
PKN1/PRK1 Conjugated Antibody |
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C35295 | SAB | 100ul | EUR 476.4 |
Protein Kinase N1 (PKN1) Antibody |
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20-abx101658 | Abbexa |
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Protein Kinase N1 (PKN1) Antibody |
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20-abx174267 | Abbexa |
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Protein Kinase N1 (PKN1) Antibody |
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20-abx135704 | Abbexa |
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Protein Kinase N1 (PKN1) Antibody |
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20-abx008827 | Abbexa |
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Protein Kinase N1 (PKN1) Antibody |
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abx135704-01mg | Abbexa | 0.1 mg | EUR 175 |
Protein Kinase N1 (PKN1) Antibody |
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abx101658-100l | Abbexa | 100 µl | EUR 250 |
Protein Kinase N1 (PKN1) Antibody |
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abx101658-1ml | Abbexa | 1 ml | EUR 675 |
Protein Kinase N1 (PKN1) Antibody |
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abx101658-200l | Abbexa | 200 µl | EUR 312.5 |
Protein Kinase N1 (PKN1) Antibody |
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abx174267-100l | Abbexa | 100 µl | EUR 712.5 |
Protein Kinase N1 (PKN1) Antibody |
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abx174267-1ml | Abbexa | 1 ml | Ask for price |
Protein Kinase N1 (PKN1) Antibody |
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abx174267-200l | Abbexa | 200 µl | Ask for price |
PKN1 Rabbit Polyclonal Antibody |
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ES8989-100ul | ELK Biotech | 100ul | EUR 124 |
Description: A Rabbit Polyclonal antibody against PKN1 from Human/Mouse/Rat. This antibody is tested and validated for WB, ELISA, WB, ELISA |
PKN1 Rabbit Polyclonal Antibody |
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ES8989-50ul | ELK Biotech | 50ul | EUR 74 |
Description: A Rabbit Polyclonal antibody against PKN1 from Human/Mouse/Rat. This antibody is tested and validated for WB, ELISA, WB, ELISA |
PKN1 Rabbit Polyclonal Antibody |
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53051 | SAB | 100ul | EUR 439 |
PKN1 Rabbit Monoclonal Antibody |
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E10G21858 | EnoGene | 100 μl | EUR 275 |
Description: Biotin-Conjugated, FITC-Conjugated , AF350 Conjugated , AF405M-Conjugated ,AF488-Conjugated, AF514-Conjugated ,AF532-Conjugated, AF555-Conjugated ,AF568-Conjugated , HRP-Conjugated, AF405S-Conjugated, AF405L-Conjugated , AF546-Conjugated, AF594-Conjugated , AF610-Conjugated, AF635-Conjugated , AF647-Conjugated , AF680-Conjugated , AF700-Conjugated , AF750-Conjugated , AF790-Conjugated , APC-Conjugated , PE-Conjugated , Cy3-Conjugated , Cy5-Conjugated , Cy5.5-Conjugated , Cy7-Conjugated Antibody |
PKN1 Rabbit Polyclonal Antibody |
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E10G34418 | EnoGene | 100 μl | EUR 275 |
Description: Biotin-Conjugated, FITC-Conjugated , AF350 Conjugated , AF405M-Conjugated ,AF488-Conjugated, AF514-Conjugated ,AF532-Conjugated, AF555-Conjugated ,AF568-Conjugated , HRP-Conjugated, AF405S-Conjugated, AF405L-Conjugated , AF546-Conjugated, AF594-Conjugated , AF610-Conjugated, AF635-Conjugated , AF647-Conjugated , AF680-Conjugated , AF700-Conjugated , AF750-Conjugated , AF790-Conjugated , APC-Conjugated , PE-Conjugated , Cy3-Conjugated , Cy5-Conjugated , Cy5.5-Conjugated , Cy7-Conjugated Antibody |
PKN1/2 (pT774/816) Antibody |
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E38PA5781 | EnoGene | 100ul | EUR 225 |
Description: Available in various conjugation types. |
Monoclonal PKN1 Antibody, Clone: 4H10B1 |
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AMM03009G | Leading Biology | 0.1ml | EUR 633.6 |
Description: A Monoclonal antibody against Human PKN1. The antibodies are raised in Mouse and are from clone 4H10B1. This antibody is applicable in WB and IHC, FC, ICC, E |
Monoclonal PKN1 Antibody, Clone: EPR3238 |
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AMM07214G | Leading Biology | 0.1ml | EUR 633.6 |
Description: A Monoclonal antibody against Human PKN1. The antibodies are raised in Rabbit and are from clone EPR3238. This antibody is applicable in WB, FC |
Antibody for Human PKN1 (pThr774) |
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SPC-1065D-A565 | Stressmarq | 0.1ml | EUR 480 |
Description: A polyclonal antibody for PKN1 (pThr774) from Human. The antibody is produced in rabbit after immunization with Human A phospho-specific peptide corresponding to residues surrounding Thr774 of human PKN1 (AA771-777). The Antibody is tested and validated for WB, AM assays with the following recommended dilutions: WB (1:250). This PKN1 (pThr774) antibody is conjugated to ATTO 565. |
Antibody for Human PKN1 (pThr774) |
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SPC-1065D-A633 | Stressmarq | 0.1ml | EUR 480 |
Description: A polyclonal antibody for PKN1 (pThr774) from Human. The antibody is produced in rabbit after immunization with Human A phospho-specific peptide corresponding to residues surrounding Thr774 of human PKN1 (AA771-777). The Antibody is tested and validated for WB, AM assays with the following recommended dilutions: WB (1:250). This PKN1 (pThr774) antibody is conjugated to ATTO 633. |
Antibody for Human PKN1 (pThr774) |
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SPC-1065D-A655 | Stressmarq | 0.1ml | EUR 480 |
Description: A polyclonal antibody for PKN1 (pThr774) from Human. The antibody is produced in rabbit after immunization with Human A phospho-specific peptide corresponding to residues surrounding Thr774 of human PKN1 (AA771-777). The Antibody is tested and validated for WB, AM assays with the following recommended dilutions: WB (1:250). This PKN1 (pThr774) antibody is conjugated to ATTO 655. |
Antibody for Human PKN1 (pThr774) |
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SPC-1065D-A680 | Stressmarq | 0.1ml | EUR 480 |
Description: A polyclonal antibody for PKN1 (pThr774) from Human. The antibody is produced in rabbit after immunization with Human A phospho-specific peptide corresponding to residues surrounding Thr774 of human PKN1 (AA771-777). The Antibody is tested and validated for WB, AM assays with the following recommended dilutions: WB (1:250). This PKN1 (pThr774) antibody is conjugated to ATTO 680. |
Antibody for Human PKN1 (pThr774) |
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SPC-1065D-A700 | Stressmarq | 0.1ml | EUR 480 |
Description: A polyclonal antibody for PKN1 (pThr774) from Human. The antibody is produced in rabbit after immunization with Human A phospho-specific peptide corresponding to residues surrounding Thr774 of human PKN1 (AA771-777). The Antibody is tested and validated for WB, AM assays with the following recommended dilutions: WB (1:250). This PKN1 (pThr774) antibody is conjugated to ATTO 700. |
Antibody for Human PKN1 (pThr774) |
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SPC-1065D-ALP | Stressmarq | 0.1ml | EUR 472.8 |
Description: A polyclonal antibody for PKN1 (pThr774) from Human. The antibody is produced in rabbit after immunization with Human A phospho-specific peptide corresponding to residues surrounding Thr774 of human PKN1 (AA771-777). The Antibody is tested and validated for WB, AM assays with the following recommended dilutions: WB (1:250). This PKN1 (pThr774) antibody is conjugated to Alkaline Phosphatase. |
Antibody for Human PKN1 (pThr774) |
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SPC-1065D-APC | Stressmarq | 0.1ml | EUR 478.8 |
Description: A polyclonal antibody for PKN1 (pThr774) from Human. The antibody is produced in rabbit after immunization with Human A phospho-specific peptide corresponding to residues surrounding Thr774 of human PKN1 (AA771-777). The Antibody is tested and validated for WB, AM assays with the following recommended dilutions: WB (1:250). This PKN1 (pThr774) antibody is conjugated to APC . |
Antibody for Human PKN1 (pThr774) |
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SPC-1065D-APCCY7 | Stressmarq | 0.1ml | EUR 565.2 |
Description: A polyclonal antibody for PKN1 (pThr774) from Human. The antibody is produced in rabbit after immunization with Human A phospho-specific peptide corresponding to residues surrounding Thr774 of human PKN1 (AA771-777). The Antibody is tested and validated for WB, AM assays with the following recommended dilutions: WB (1:250). This PKN1 (pThr774) antibody is conjugated to APC/Cy7. |
Antibody for Human PKN1 (pThr774) |
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SPC-1065D-DY350 | Stressmarq | 0.1ml | EUR 570 |
Description: A polyclonal antibody for PKN1 (pThr774) from Human. The antibody is produced in rabbit after immunization with Human A phospho-specific peptide corresponding to residues surrounding Thr774 of human PKN1 (AA771-777). The Antibody is tested and validated for WB, AM assays with the following recommended dilutions: WB (1:250). This PKN1 (pThr774) antibody is conjugated to Dylight 350. |
Antibody for Human PKN1 (pThr774) |
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SPC-1065D-DY405 | Stressmarq | 0.1ml | EUR 542.4 |
Description: A polyclonal antibody for PKN1 (pThr774) from Human. The antibody is produced in rabbit after immunization with Human A phospho-specific peptide corresponding to residues surrounding Thr774 of human PKN1 (AA771-777). The Antibody is tested and validated for WB, AM assays with the following recommended dilutions: WB (1:250). This PKN1 (pThr774) antibody is conjugated to Dylight 405. |
Antibody for Human PKN1 (pThr774) |
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SPC-1065D-DY488 | Stressmarq | 0.1ml | EUR 518.4 |
Description: A polyclonal antibody for PKN1 (pThr774) from Human. The antibody is produced in rabbit after immunization with Human A phospho-specific peptide corresponding to residues surrounding Thr774 of human PKN1 (AA771-777). The Antibody is tested and validated for WB, AM assays with the following recommended dilutions: WB (1:250). This PKN1 (pThr774) antibody is conjugated to Dylight 488. |
Antibody for Human PKN1 (pThr774) |
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SPC-1065D-DY594 | Stressmarq | 0.1ml | EUR 523.2 |
Description: A polyclonal antibody for PKN1 (pThr774) from Human. The antibody is produced in rabbit after immunization with Human A phospho-specific peptide corresponding to residues surrounding Thr774 of human PKN1 (AA771-777). The Antibody is tested and validated for WB, AM assays with the following recommended dilutions: WB (1:250). This PKN1 (pThr774) antibody is conjugated to Dylight 594. |
Antibody for Human PKN1 (pThr774) |
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SPC-1065D-DY633 | Stressmarq | 0.1ml | EUR 511.2 |
Description: A polyclonal antibody for PKN1 (pThr774) from Human. The antibody is produced in rabbit after immunization with Human A phospho-specific peptide corresponding to residues surrounding Thr774 of human PKN1 (AA771-777). The Antibody is tested and validated for WB, AM assays with the following recommended dilutions: WB (1:250). This PKN1 (pThr774) antibody is conjugated to Dylight 633. |
Antibody for Human PKN1 (pThr774) |
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SPC-1065D-HRP | Stressmarq | 0.1ml | EUR 465.6 |
Description: A polyclonal antibody for PKN1 (pThr774) from Human. The antibody is produced in rabbit after immunization with Human A phospho-specific peptide corresponding to residues surrounding Thr774 of human PKN1 (AA771-777). The Antibody is tested and validated for WB, AM assays with the following recommended dilutions: WB (1:250). This PKN1 (pThr774) antibody is conjugated to HRP. |
Antibody for Human PKN1 (pThr774) |
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SPC-1065D-P594 | Stressmarq | 0.1ml | EUR 488.4 |
Description: A polyclonal antibody for PKN1 (pThr774) from Human. The antibody is produced in rabbit after immunization with Human A phospho-specific peptide corresponding to residues surrounding Thr774 of human PKN1 (AA771-777). The Antibody is tested and validated for WB, AM assays with the following recommended dilutions: WB (1:250). This PKN1 (pThr774) antibody is conjugated to PE/ATTO 594. |
Antibody for Human PKN1 (pThr774) |
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SPC-1065D-PCP | Stressmarq | 0.1ml | EUR 478.8 |
Description: A polyclonal antibody for PKN1 (pThr774) from Human. The antibody is produced in rabbit after immunization with Human A phospho-specific peptide corresponding to residues surrounding Thr774 of human PKN1 (AA771-777). The Antibody is tested and validated for WB, AM assays with the following recommended dilutions: WB (1:250). This PKN1 (pThr774) antibody is conjugated to PerCP. |
Antibody for Human PKN1 (pThr774) |
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SPC-1065D-RPE | Stressmarq | 0.1ml | EUR 476.4 |
Description: A polyclonal antibody for PKN1 (pThr774) from Human. The antibody is produced in rabbit after immunization with Human A phospho-specific peptide corresponding to residues surrounding Thr774 of human PKN1 (AA771-777). The Antibody is tested and validated for WB, AM assays with the following recommended dilutions: WB (1:250). This PKN1 (pThr774) antibody is conjugated to RPE . |
Antibody for Human PKN1 (pThr774) |
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SPC-1065D-STR | Stressmarq | 0.1ml | EUR 477.6 |
Description: A polyclonal antibody for PKN1 (pThr774) from Human. The antibody is produced in rabbit after immunization with Human A phospho-specific peptide corresponding to residues surrounding Thr774 of human PKN1 (AA771-777). The Antibody is tested and validated for WB, AM assays with the following recommended dilutions: WB (1:250). This PKN1 (pThr774) antibody is conjugated to Streptavidin. |
Mouse Monoclonal Antibody to PKN1 |
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E10-30717 | EnoGene | 100ul | EUR 225 |
Description: Available in various conjugation types. |
Mouse Monoclonal Antibody to PKN1 |
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E10-30717T | EnoGene | 100ul | EUR 225 |
Description: Available in various conjugation types. |
Mouse Monoclonal Antibody to PKN1 |
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sAP-1066 | Angio Proteomie | 50ug | EUR 270 |
Protein Kinase N1 (PKN1) Polyclonal Antibody |
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CAU27791-100ul | Biomatik Corporation | 100ul | EUR 211.2 |
Protein Kinase N1 (PKN1) Polyclonal Antibody |
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CAU27791-200ul | Biomatik Corporation | 200ul | EUR 263.8 |
Serine/Threonine-Protein Kinase N1 (PKN1) Antibody |
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20-abx327640 | Abbexa |
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Serine/Threonine-Protein Kinase N1 (PKN1) Antibody |
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abx224112-100ug | Abbexa | 100 ug | EUR 493.2 |
Serine/Threonine-Protein Kinase N1 (PKN1) Antibody |
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abx149738-100ug | Abbexa | 100 ug | EUR 526.8 |
Serine/Threonine-Protein Kinase N1 (PKN1) Antibody |
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20-abx015170 | Abbexa |
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Serine/Threonine-Protein Kinase N1 (PKN1) Antibody |
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abx015170-100g | Abbexa | 100 µg | EUR 43.75 |
Serine/Threonine-Protein Kinase N1 (PKN1) Antibody |
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abx224112-100l | Abbexa | 100 µl | Ask for price |
Serine/Threonine-Protein Kinase N1 (PKN1) Antibody |
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abx224112-50l | Abbexa | 50 µl | EUR 362.5 |
Serine/Threonine-Protein Kinase N1 (PKN1) Antibody |
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abx327640-100g | Abbexa | 100 µg | EUR 250 |
Serine/Threonine-Protein Kinase N1 (PKN1) Antibody |
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abx327640-50g | Abbexa | 50 µg | EUR 187.5 |
ARP54944_P050-25UL - Pkn1 Antibody - C-terminal region |
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ARP54944_P050-25UL | Aviva Systems Biology | 25ul | EUR 99 |
ARP54944_P050 - Pkn1 Antibody - C-terminal region (ARP54944_P050) |
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ARP54944_P050 | Aviva Systems Biology | 100ul | EUR 389 |
Mouse Monoclonal anti-human PKN1 |
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hAP-1071 | Angio Proteomie | 50ug | EUR 400 |
Polyclonal Antibody to Protein Kinase N1 (PKN1) |
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PAA501Hu01 | Cloud-Clone | 100ul | EUR 220 |
Protein Kinase N1 (PKN1) Polyclonal Antibody (Human) |
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4-PAA501Hu01 | Cloud-Clone |
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Description: A Rabbit polyclonal antibody against Human Protein Kinase N1 (PKN1) |