Protein misfolded oligomers from cell membranes and abrogates their cytotoxicity

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Trodusquemine displaces protein misfolded oligomers from cell membranes and abrogates their cytotoxicity through a generic mechanism

 

The onset and progression of numerous protein misfolding diseases are associated with the presence of oligomers formed during the aberrant aggregation of several different proteins, including amyloid-β (Aβ) in Alzheimer’s disease and α-synuclein (αS) in Parkinson’s disease.
These small, soluble aggregates are currently major targets for drug discovery. In this study, we show that trodusquemine, a naturally-occurring aminosterol, markedly reduces the cytotoxicity of αS, Aβ and HypF-N oligomers to human neuroblastoma cells by displacing the oligomers from cell membranes in the absence of any substantial morphological and structural changes to the oligomers.
These results indicate that the reduced toxicity results from a mechanism that is common to oligomers from different proteins, shed light on the origin of the toxicity of the most deleterious species associated with protein aggregation and suggest that aminosterols have the therapeutically-relevant potential to protect cells from the oligomer-induced cytotoxicity associated with numerous protein misfolding diseases.

Comparing supermarket loyalty card data with traditional diet survey data for understanding how protein is purchased and consumed in older adults for the UK, 2014-16

Background: Our ability to understand population-level dietary intake patterns is dependent on having access to high quality data. Diet surveys are common diet assessment methods, but can be limited by bias associated with under-reporting.
Food purchases tracked using supermarket loyalty card records may supplement traditional surveys, however they are rarely available to academics and policy makers. The aim of our study is to explore population level patterns of protein purchasing and consumption in ageing adults (40 years onwards).
Methods: We used diet survey data from the National Diet and Nutrition Survey (2014-16) on food consumption, and loyalty card records on food purchases from a major high street supermarket retailer (2016-17) covering the UK. We computed the percentage of total energy derived from protein, protein intake per kg of body mass, and percentage of protein acquired by food type.
Results: We found that protein consumption (as the percentage of total energy purchased) increased between ages 40-65 years, and declined thereafter. In comparison, protein purchased in supermarkets was roughly 2-2.5 percentage points lower at each year of age.
The proportion of adults meeting recommended levels of protein was lowest in age groups 55-69 and 70+. The time of protein consumption was skewed towards evening meals, with low intakes during breakfast or between main meals. Meat, fish and poultry dominated as sources of protein purchased and consumed, although adults also acquired a large share of their protein from dairy and bread, with little from plant protein.
Conclusions: Our study provides novel insights into how protein is purchased and consumed by ageing adults in the UK. Supermarket loyalty card data can reveal patterns of protein purchasing that when combined with traditional sources of dietary intake may enhance our understanding of dietary behaviors.
Keywords: Big data; Diet surveys; Population; Protein; Supermarket loyalty cards.
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Recombinant EBV EBNA1 Mosaic Protein, His, E.coli-100ug
QP11732-100ug 100ug
EUR 261.6

Recombinant EBV EBNA1 Mosaic Protein, His, E.coli-1mg
QP11732-1mg 1mg
EUR 1273.2

Recombinant EBV EBNA1 Mosaic Protein, His, E.coli-500ug
QP11732-500ug 500ug
EUR 795.6

EBNA1 protein
30-1925 500 ug
EUR 678
Description: Purified Recombinant EBNA1 protein

Recombinant EBV EBNA1 Mosaic Protein (aa 1-90 & 408-498) [His]
VAng-2528Lsx-100g 100 µg
EUR 555.6
Description: EBV EBNA1 Mosaic protein, His tag at C-terminus, recombinant protein from E. coli.

Recombinant EBV EBNA1 Mosaic Protein (aa 1-90 & 408-498) [His]
VAng-2528Lsx-1mg 1 mg
EUR 3360
Description: EBV EBNA1 Mosaic protein, His tag at C-terminus, recombinant protein from E. coli.

Recombinant EBV EBNA1 Mosaic Protein (aa 1-90 & 408-498) [His]
VAng-2528Lsx-500g 500 µg
EUR 2040
Description: EBV EBNA1 Mosaic protein, His tag at C-terminus, recombinant protein from E. coli.

Recombinant EBV EBNA1 Mosaic Protein (aa 1-90 & 408-498) [GST]
VAng-Lsx0111-100g 100 µg
EUR 759.6
Description: EBV EBNA1 Mosaic protein [GST], recombinant protein from E. coli.

Recombinant EBV EBNA1 Mosaic Protein (aa 1-90 & 408-498) [GST]
VAng-Lsx0111-500g 500 µg
EUR 2419.2
Description: EBV EBNA1 Mosaic protein [GST], recombinant protein from E. coli.

pCXWB- EBNA1
PVT10196 2 ug
EUR 361.2

Recombinant (E.Coli, GST tag) Epstein-Barr Virus (EBV/HHV-4) Mosaic EBNA1
RP-347 100 ug
EUR 343.2

EBNA1 protein (His tag)
80-1340 100 ug
EUR 289.2
Description: Purified recombinant EBNA1 protein (His tag)

Recombinant EBNA1 Protein [GST]
VAng-Lsx0122-100g 100 µg
EUR 818.4
Description: EBNA1 (EBV) (P03211) partial recombinant protein with GST tag expressed in E. coli.

EBV protein
30-1275 1 mg
EUR 4177.2
Description: Purified recombinant EBV protein

EBV protein
30-1276 1 mg
EUR 4177.2
Description: Purified recombinant EBV protein

EBV Protein
abx069822-1ml 1 ml
EUR 828

EBV Protein
abx069824-1mg 1 mg
EUR 1762.8

EBV Protein
abx069825-1ml 1 ml
EUR 376.8

EBV Protein
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EUR 2180.4

EBV Protein
abx069829-1mg 1 mg
EUR 2131.2

EBNA1 Binding Protein 2 Protein
20-abx260778
  • EUR 4101.60
  • EUR 393.60
  • EUR 276.00
  • 1 mg
  • 20 ug
  • 5 ug

pCXWB- EBNA1 Plasmid
PVT7175 2 ug
EUR 319.2

EBV EA protein
30R-AE005 100 ug
EUR 392.4
Description: Purified recombinant EBV EA protein

EBV p18 protein
30R-AE007 500 ug
EUR 967.2
Description: Purified recombinant EBV p18 protein

EBV p23 protein
30R-AE008 100 ug
EUR 392.4
Description: Purified recombinant EBV p23 protein

EBV EA protein
30-1280 1 mg
EUR 4177.2
Description: Purified recombinant EBV EA protein

EBV VCA protein
30-1811 1 ml
EUR 457.2
Description: Purified native EBV VCA gp125 protein

EBV EA protein
30-1920 1 ml
EUR 496.8
Description: Viral lysate containing a high concentration of EBV antigens, including VCA, EBNA, EA-D and EA-R

EBV EBNA protein
30-AE46 200 ug
EUR 900
Description: Purified recombinant EBV EBNA protein

EBV EA protein
30-AE50 200 ug
EUR 975.6
Description: Purified recombinant EBV EA protein

Recombinant EBV Protein
VAng-Lsx0108-inquire inquire Ask for price
Description: EBV, recombinant protein from human cells.

EBNA1 (GFP-Puro) Lentivirus
LVP1134-GP 1x107 IFU/ml x 200ul
EUR 418.8
Description: Premade lentivirus expressing Epstein Barr Virus' EBNA1 gene under EF1a promoter, containing GFP-Puromycin dual marker.

EBNA1 (RFP-Bsd) Lentivirus
LVP1134-RB 1x107 IFU/ml x 200ul
EUR 418.8
Description: Premade lentivirus expressing Epstein Barr Virus' EBNA1 gene under EF1a promoter, containing RFP-Blasticidin dual marker.

EBNA1 Binding Protein 2 (EBNA1BP2) Antibody
20-abx123650
  • EUR 493.20
  • EUR 710.40
  • EUR 218.40
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  • 100 ul
  • 200 ul
  • 20 ul
  • 50 ul

EBNA1 Binding Protein 2 (EBNA1BP2) Antibody
abx026949-400ul 400 ul
EUR 627.6

EBNA1 Binding Protein 2 (EBNA1BP2) Antibody
abx026949-80l 80 µl
EUR 343.2

EBV [His]
DAG1578 100 µg
EUR 972

EBV [GST]
DAG1580 100 µg
EUR 774

EBV [GST]
DAG1581 100 µg
EUR 972

EBV [His]
DAG1584 100 µg
EUR 972

EBV antibody
10-E40C 200 ug
EUR 274.8
Description: Mouse monoclonal EBV antibody

EBV antibody
10-E40D 200 ug
EUR 163.2
Description: Mouse monoclonal EBV antibody

EBV antibody
10-E40E 200 ug
EUR 254.4
Description: Mouse monoclonal EBV antibody

EBV Virus
G229 10 ml
EUR 882

EBV P18 Mosaic protein
DAG1582 100 µg
EUR 774

EBV VCA p23 Protein
abx069823-1mg 1 mg
EUR 1796.4

Recombinant EBV Protein [His]
VAng-Lsx0112-inquire inquire Ask for price
Description: EBV [His], recombinant protein from E. coli.

Recombinant EBV P125 Protein
VAng-Lsx0119-1mL 1 mL
EUR 465.6
Description: EBV P125 Protein, recombinant protein from E. coli.

Recombinant EBV P125 Protein
VAng-Lsx0119-25mL 25 mL
EUR 7318.8
Description: EBV P125 Protein, recombinant protein from E. coli.

Epstein-Barr Virus (HHV-4) EBNA1 Protein
20-abx260340
  • EUR 1345.20
  • EUR 560.40
  • EUR 2364.00
  • 0.5 mg
  • 100 ug
  • 1 mg

Recombinant EBNA1 Protein [His] (1.185 mg/mL)
VAng-0610Lsx-inquire inquire Ask for price
Description: Epstein-Barr Virus (EBV) Nuclear Antigen-1 (EBNA-1), recombinant protein from E. coli. MW 63 kDa, 1.185 mg/mL.

Recombinant EBNA1 Protein [His] (1.25 mg/mL)
VAng-0611Lsx-inquire inquire Ask for price
Description: Epstein-Barr Virus (EBV) Nuclear Antigen-1 (EBNA-1), recombinant protein from E. coli. MW 63 kDa, 1.25 mg/mL.

EBNA1BP2 EBNA1 Binding Protein 2 Human Recombinant Protein
PROTQ99848 Regular: 20ug
EUR 380.4
Description: Recombinant Human EBNA1BP2 produced in E. coli is a single polypeptide chain containing 329 amino acids (1-306) and having a molecular mass of 37.2kDa.;EBNA1BP2 is fused to a 23 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.

EBV HHV-4 p23 Protein
abx060518-1mg 1 mg
EUR 2264.4

EBV p54 (EA-D) Protein
abx061433-1mg 1 mg
EUR 1813.2

EBV p18 protein (His tag)
80-1355S 100 ug
EUR 289.2
Description: Purified recombinant EBV p18 protein (His tag)

EBV p54 protein (His tag)
80-1361 1 mg
EUR 1299.6
Description: Purified recombinant EBV p54 protein (His tag)

EBV p138 protein (His tag)
80-1362 1 mg
EUR 1299.6
Description: Purified recombinant EBV p138 protein (His tag)

Recombinant EBV P138 Protein [His]
VAng-0612Lsx-inquire inquire Ask for price
Description: EBV p138 Early Antigen D (EA-D) Protein, recombinant protein from E. coli. 1.00 mg/mL.

Recombinant EBV P54 Protein [His]
VAng-0613Lsx-inquire inquire Ask for price
Description: EBV p54 Early Antigen D (EA-D) Protein, recombinant protein from E. coli. 1.068 mg/mL.

Recombinant EBV P18 Protein [His]
VAng-0614Lsx-inquire inquire Ask for price
Description: EBV Viral Capsid Antigen (VCA) p18, recombinant protein from E. coli. 2.14 mg/mL.

Recombinant EBV p23 Protein [GST]
VAng-0617Lsx-inquire inquire Ask for price
Description: EBV p23, recombinant protein from E. coli. 1.00 mg/mL.

Recombinant EBV P18 Mosaic Protein
VAng-Lsx0115-inquire inquire Ask for price
Description: EBV P18 Mosaic protein, recombinant protein from E. coli.

Recombinant EBV P23 Protein [His]
VAng-Lsx0117-inquire inquire Ask for price
Description: Recombinant EBV p23 protein was expressed in E. coli and purified by proprietary chromatographic technique, 17.7kDa.

Recombinant EBV BFRF3 Protein [GST]
VAng-Lsx0120-inquire inquire Ask for price
Description: BFRF3 (EBV) (P14348) partial recombinant protein with GST tag expressed in E. coli.

Recombinant EBV BMRF1 Protein [GST]
VAng-Lsx0121-inquire inquire Ask for price
Description: BMRF1 (EBV) (P03191) partial recombinant protein with GST tag expressed in E. coli.

Inactivated EBV gp125 VCA Protein
VAng-Lsx04574-1mL 1 mL
EUR 423.6
Description: Epstein-Barr Virus (Strain P3HR1) gp125 VCA, inactivated antigen.

Inactivated EBV gp125 VCA Protein
VAng-Lsx04574-25mL 25 mL
EUR 7318.8
Description: Epstein-Barr Virus (Strain P3HR1) gp125 VCA, inactivated antigen.

EBV Glycoprotein 125
DAG3085 25 ml
EUR 1966.8

Recombinant EBV p18
DAGA-3074 100ug
EUR 1279.2

EBV BMRF1 [GST]
DAG1849 500 ug
EUR 3034.8

EBV antibody (VCA)
10-E40B 200 ug
EUR 274.8
Description: Mouse monoclonal EBV antibody (VCA)

EBV LMP2A Antibody
abx021712-025mg 0.25 mg
EUR 1212

Inactivated EBV Antigen
VAng-Lsx0109-1mL 1 mL
EUR 1632
Description: EBV, natural antigen.

Human EBNA1 Binding Protein 2 (EBNA1BP2) ELISA Kit
abx384822-96tests 96 tests
EUR 1093.2

Epstein-Barr Virus (HHV-4) Mosaic EBNA1 Protein
20-abx260113
  • EUR 1062.00
  • EUR 410.40
  • EUR 1646.40
  • 0.5 mg
  • 100 ug
  • 1 mg

Mouse EBNA1 Binding Protein 2 (EBNA1BP2) ELISA Kit
abx389130-96tests 96 tests
EUR 1093.2

HHV-4 recombinant mosaic EBNA1 antigen
00212-V-01mg 0,1 mg
EUR 321
Description: HHV-4 recombinant mosaic EBNA1 antigen. Region: 1-90/408-498aa

HHV-4 recombinant mosaic EBNA1 antigen
00212-V-1000ug 1000 ug
EUR 1539
Description: HHV-4 recombinant mosaic EBNA1 antigen. Region: 1-90/408-498aa

EBNA1 (GFP-Puro) Lentivirus in PBS
LVP1134-GP-PBS 1x107 IFU/ml x 200ul
EUR 852
Description: Concentrated lentivirus in PBS expressing Epstein Barr Virus' EBNA1 gene under EF1a promoter, containing GFP-Puromycin dual marker.

EBNA1 (RFP-Bsd) Lentivirus in PBS
LVP1134-RB-PBS 1x107 IFU/ml x 200ul
EUR 852
Description: Concentrated lentivirus in PBS expressing Epstein Barr Virus' EBNA1 gene under EF1a promoter, containing RFP-Blasticidin dual marker.

The role of monoamine oxidase A in HPV-16 E7-induced epithelial-mesenchymal transition and HIF-1α protein accumulation in non-small cell lung cancer cells

 

Our previous studies have found that human papillomavirus (HPV)-16 E7 oncoprotein promotes epithelial-mesenchymal transition (EMT) and hypoxia-inducible factor-1α (HIF-1α) protein accumulation in non-small cell lung cancer (NSCLC) cells and monoamine oxidase A (MAOA) is highly expressed in NSCLC tissues.
Here, we further explored the role of MAOA in HPV-16 E7-induced EMT and HIF-1α protein accumulation in A549 and NCI-H460 NSCLC cells. Our results showed that HPV-16 E7 enhanced MAOA expression in NSCLC cells. Additionally, MAOA knockout inhibited HPV-16 E7-induced migration, invasion, and EMT, and significantly reduced HPV-16 E7-induced ROS generation and HIF-1α protein accumulation via promoting its degradation.
Furthermore, MAOA knockout suppressed HPV-16 E7-induced ERK1/2 activation. In vivo, MAOA knockout inhibited tumor growth, metastasis, and the expression of EMT-related markers and HIF-1α proteins induced by HPV-16 E7 in NCI-H460 NSCLC subcutaneous xenograft and in situ intrapulmonary models of nude mice. Taken together, our findings provide evidence that MAOA plays a key role in EMT and HIF-1α protein accumulation induced by HPV-16 E7 in NSCLC cells, suggesting that MAOA may be a potential therapeutic target for HPV-related NSCLC.

Human Protein Kinase N1 (PKN1) ELISA Kit
RD-PKN1-Hu-96Tests 96 Tests
EUR 794.4

Human Protein Kinase N1 (PKN1) ELISA Kit
RDR-PKN1-Hu-48Tests 48 Tests
EUR 600

Human Protein Kinase N1 (PKN1) ELISA Kit
RDR-PKN1-Hu-96Tests 96 Tests
EUR 830.4

Rabbit Polyclonal antibody Anti-CRBN
Anti-CRBN 50 µg
EUR 418.8

Anti-PKN1 (1B10)
YF-MA14890 100 ug
EUR 435.6
Description: Mouse monoclonal to PKN1

Anti-PKN1 (1A4)
YF-MA14891 100 ug
EUR 435.6
Description: Mouse monoclonal to PKN1

PKN1 antibody
70R-50256 100 ul
EUR 292.8
Description: Purified Polyclonal PKN1 antibody

PKN1 Antibody
48392-100ul 100ul
EUR 399.6

PKN1 Antibody
48392-50ul 50ul
EUR 286.8

PKN1 Antibody
ABD4790 100 ug
EUR 525.6

PKN1 Antibody
DF4790 200ul
EUR 420

PKN1 Antibody
1-CSB-PA030259
  • EUR 266.40
  • EUR 234.00
  • 100ug
  • 50ug
Description: A polyclonal antibody against PKN1. Recognizes PKN1 from Human, Mouse, Rat. This antibody is Unconjugated. Tested in the following application: WB, ELISA;WB:1/500-1/2000.ELISA:1/20000

PKN1/PRK1 Antibody
35295-100ul 100ul
EUR 302.4

PKN1/PRK1 Antibody
35295-50ul 50ul
EUR 224.4

PKN1 Polyclonal Antibody
ABP59926-003ml 0.03ml
EUR 189.6
Description: A polyclonal antibody for detection of PKN1 from Human, Mouse, Rat. This PKN1 antibody is for WB, ELISA. It is affinity-purified from rabbit serum by affinity-chromatography using the specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from part region of human PKN1 protein at amino acid sequence of 720-800

PKN1 Polyclonal Antibody
ABP59926-01ml 0.1ml
EUR 346.8
Description: A polyclonal antibody for detection of PKN1 from Human, Mouse, Rat. This PKN1 antibody is for WB, ELISA. It is affinity-purified from rabbit serum by affinity-chromatography using the specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from part region of human PKN1 protein at amino acid sequence of 720-800

PKN1 Polyclonal Antibody
ABP59926-02ml 0.2ml
EUR 496.8
Description: A polyclonal antibody for detection of PKN1 from Human, Mouse, Rat. This PKN1 antibody is for WB, ELISA. It is affinity-purified from rabbit serum by affinity-chromatography using the specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from part region of human PKN1 protein at amino acid sequence of 720-800

PKN1 Conjugated Antibody
C48392 100ul
EUR 476.4

PKN1 Polyclonal Antibody
ES8989-100ul 100ul
EUR 334.8
Description: A Rabbit Polyclonal antibody against PKN1 from Human/Mouse/Rat. This antibody is tested and validated for WB, ELISA, WB, ELISA

PKN1 Polyclonal Antibody
ES8989-50ul 50ul
EUR 248.4
Description: A Rabbit Polyclonal antibody against PKN1 from Human/Mouse/Rat. This antibody is tested and validated for WB, ELISA, WB, ELISA

Pkn1/ Rat Pkn1 ELISA Kit
ELI-37289r 96 Tests
EUR 1063.2

PKN1 siRNA
20-abx904045
  • EUR 661.20
  • EUR 878.40
  • 15 nmol
  • 30 nmol

PKN1 siRNA
20-abx928745
  • EUR 661.20
  • EUR 878.40
  • 15 nmol
  • 30 nmol

PKN1 siRNA
20-abx928746
  • EUR 661.20
  • EUR 878.40
  • 15 nmol
  • 30 nmol

PKN1/PRK1 Conjugated Antibody
C35295 100ul
EUR 476.4

PKN1 Antibody (C-Terminal)
F53997-0.05ML 0.05 ml
EUR 165

PKN1 Antibody (C-Terminal)
F53997-0.2ML 0.2 ml
EUR 379

Polyclonal Goat anti-GST α-form
GST-ANTI-1 50 uL
EUR 336

Polyclonal Goat anti-GST μ-form
GST-ANTI-2 50 uL
EUR 336

Polyclonal Goat anti-GST p-form
GST-ANTI-3 50 uL
EUR 336

PKN1 Rabbit pAb
A0553-100ul 100 ul
EUR 369.6

PKN1 Rabbit pAb
A0553-200ul 200 ul
EUR 550.8

PKN1 Rabbit pAb
A0553-20ul 20 ul
EUR 219.6

PKN1 Rabbit pAb
A0553-50ul 50 ul
EUR 267.6

PKN1 Blocking Peptide
20-abx063131
  • EUR 326.40
  • EUR 493.20
  • 1 mg
  • 5 mg

PKN1 Blocking Peptide
DF4790-BP 1mg
EUR 234

PKN1 cloning plasmid
CSB-CL623082HU-10ug 10ug
EUR 1082.4
Description: A cloning plasmid for the PKN1 gene.

Protein Kinase N1 (PKN1) Antibody
20-abx135704
  • EUR 493.20
  • EUR 710.40
  • EUR 218.40
  • EUR 376.80
  • 100 ul
  • 200 ul
  • 20 ul
  • 50 ul

Protein Kinase N1 (PKN1) Antibody
20-abx101658
  • EUR 360.00
  • EUR 159.60
  • EUR 895.20
  • EUR 477.60
  • EUR 309.60
  • 100 ug
  • 10 ug
  • 1 mg
  • 200 ug
  • 50 ug

Protein Kinase N1 (PKN1) Antibody
20-abx008827
  • EUR 360.00
  • EUR 526.80
  • EUR 226.80
  • 100 ul
  • 200 ul
  • 30 ul

Protein Kinase N1 (PKN1) Antibody
20-abx174267
  • EUR 944.40
  • EUR 493.20
  • 1 mg
  • 200 ug

Monoclonal PKN1 Antibody, Clone: 4H10B1
AMM03009G 0.1ml
EUR 633.6
Description: A Monoclonal antibody against Human PKN1. The antibodies are raised in Mouse and are from clone 4H10B1. This antibody is applicable in WB and IHC, FC, ICC, E

Monoclonal PKN1 Antibody, Clone: EPR3238
AMM07214G 0.1ml
EUR 633.6
Description: A Monoclonal antibody against Human PKN1. The antibodies are raised in Rabbit and are from clone EPR3238. This antibody is applicable in WB, FC

Antibody for Human PKN1 (pThr774)
SPC-1065D 0.1ml
EUR 424.8
Description: A polyclonal antibody for PKN1 (pThr774) from Human. The antibody is produced in rabbit after immunization with Human A phospho-specific peptide corresponding to residues surrounding Thr774 of human PKN1 (AA771-777). The Antibody is tested and validated for WB, AM assays with the following recommended dilutions: WB (1:250). This PKN1 (pThr774) antibody is unconjugated.

Antibody for Human PKN1 (pThr774)
SPC-1065D-A390 0.1ml
EUR 481.2
Description: A polyclonal antibody for PKN1 (pThr774) from Human. The antibody is produced in rabbit after immunization with Human A phospho-specific peptide corresponding to residues surrounding Thr774 of human PKN1 (AA771-777). The Antibody is tested and validated for WB, AM assays with the following recommended dilutions: WB (1:250). This PKN1 (pThr774) antibody is conjugated to ATTO 390.

Antibody for Human PKN1 (pThr774)
SPC-1065D-A488 0.1ml
EUR 480
Description: A polyclonal antibody for PKN1 (pThr774) from Human. The antibody is produced in rabbit after immunization with Human A phospho-specific peptide corresponding to residues surrounding Thr774 of human PKN1 (AA771-777). The Antibody is tested and validated for WB, AM assays with the following recommended dilutions: WB (1:250). This PKN1 (pThr774) antibody is conjugated to ATTO 488.

Antibody for Human PKN1 (pThr774)
SPC-1065D-A565 0.1ml
EUR 480
Description: A polyclonal antibody for PKN1 (pThr774) from Human. The antibody is produced in rabbit after immunization with Human A phospho-specific peptide corresponding to residues surrounding Thr774 of human PKN1 (AA771-777). The Antibody is tested and validated for WB, AM assays with the following recommended dilutions: WB (1:250). This PKN1 (pThr774) antibody is conjugated to ATTO 565.

Antibody for Human PKN1 (pThr774)
SPC-1065D-A594 0.1ml
EUR 480
Description: A polyclonal antibody for PKN1 (pThr774) from Human. The antibody is produced in rabbit after immunization with Human A phospho-specific peptide corresponding to residues surrounding Thr774 of human PKN1 (AA771-777). The Antibody is tested and validated for WB, AM assays with the following recommended dilutions: WB (1:250). This PKN1 (pThr774) antibody is conjugated to ATTO 594.

Antibody for Human PKN1 (pThr774)
SPC-1065D-A633 0.1ml
EUR 480
Description: A polyclonal antibody for PKN1 (pThr774) from Human. The antibody is produced in rabbit after immunization with Human A phospho-specific peptide corresponding to residues surrounding Thr774 of human PKN1 (AA771-777). The Antibody is tested and validated for WB, AM assays with the following recommended dilutions: WB (1:250). This PKN1 (pThr774) antibody is conjugated to ATTO 633.

Antibody for Human PKN1 (pThr774)
SPC-1065D-A655 0.1ml
EUR 480
Description: A polyclonal antibody for PKN1 (pThr774) from Human. The antibody is produced in rabbit after immunization with Human A phospho-specific peptide corresponding to residues surrounding Thr774 of human PKN1 (AA771-777). The Antibody is tested and validated for WB, AM assays with the following recommended dilutions: WB (1:250). This PKN1 (pThr774) antibody is conjugated to ATTO 655.

Antibody for Human PKN1 (pThr774)
SPC-1065D-A680 0.1ml
EUR 480
Description: A polyclonal antibody for PKN1 (pThr774) from Human. The antibody is produced in rabbit after immunization with Human A phospho-specific peptide corresponding to residues surrounding Thr774 of human PKN1 (AA771-777). The Antibody is tested and validated for WB, AM assays with the following recommended dilutions: WB (1:250). This PKN1 (pThr774) antibody is conjugated to ATTO 680.

Antibody for Human PKN1 (pThr774)
SPC-1065D-A700 0.1ml
EUR 480
Description: A polyclonal antibody for PKN1 (pThr774) from Human. The antibody is produced in rabbit after immunization with Human A phospho-specific peptide corresponding to residues surrounding Thr774 of human PKN1 (AA771-777). The Antibody is tested and validated for WB, AM assays with the following recommended dilutions: WB (1:250). This PKN1 (pThr774) antibody is conjugated to ATTO 700.

Antibody for Human PKN1 (pThr774)
SPC-1065D-ALP 0.1ml
EUR 472.8
Description: A polyclonal antibody for PKN1 (pThr774) from Human. The antibody is produced in rabbit after immunization with Human A phospho-specific peptide corresponding to residues surrounding Thr774 of human PKN1 (AA771-777). The Antibody is tested and validated for WB, AM assays with the following recommended dilutions: WB (1:250). This PKN1 (pThr774) antibody is conjugated to Alkaline Phosphatase.

Antibody for Human PKN1 (pThr774)
SPC-1065D-APC 0.1ml
EUR 478.8
Description: A polyclonal antibody for PKN1 (pThr774) from Human. The antibody is produced in rabbit after immunization with Human A phospho-specific peptide corresponding to residues surrounding Thr774 of human PKN1 (AA771-777). The Antibody is tested and validated for WB, AM assays with the following recommended dilutions: WB (1:250). This PKN1 (pThr774) antibody is conjugated to APC .

Antibody for Human PKN1 (pThr774)
SPC-1065D-APCCY7 0.1ml
EUR 565.2
Description: A polyclonal antibody for PKN1 (pThr774) from Human. The antibody is produced in rabbit after immunization with Human A phospho-specific peptide corresponding to residues surrounding Thr774 of human PKN1 (AA771-777). The Antibody is tested and validated for WB, AM assays with the following recommended dilutions: WB (1:250). This PKN1 (pThr774) antibody is conjugated to APC/Cy7.

Antibody for Human PKN1 (pThr774)
SPC-1065D-BI 0.1ml
EUR 475.2
Description: A polyclonal antibody for PKN1 (pThr774) from Human. The antibody is produced in rabbit after immunization with Human A phospho-specific peptide corresponding to residues surrounding Thr774 of human PKN1 (AA771-777). The Antibody is tested and validated for WB, AM assays with the following recommended dilutions: WB (1:250). This PKN1 (pThr774) antibody is conjugated to Biotin.

Antibody for Human PKN1 (pThr774)
SPC-1065D-DY350 0.1ml
EUR 570
Description: A polyclonal antibody for PKN1 (pThr774) from Human. The antibody is produced in rabbit after immunization with Human A phospho-specific peptide corresponding to residues surrounding Thr774 of human PKN1 (AA771-777). The Antibody is tested and validated for WB, AM assays with the following recommended dilutions: WB (1:250). This PKN1 (pThr774) antibody is conjugated to Dylight 350.

Antibody for Human PKN1 (pThr774)
SPC-1065D-DY405 0.1ml
EUR 542.4
Description: A polyclonal antibody for PKN1 (pThr774) from Human. The antibody is produced in rabbit after immunization with Human A phospho-specific peptide corresponding to residues surrounding Thr774 of human PKN1 (AA771-777). The Antibody is tested and validated for WB, AM assays with the following recommended dilutions: WB (1:250). This PKN1 (pThr774) antibody is conjugated to Dylight 405.

Antibody for Human PKN1 (pThr774)
SPC-1065D-DY488 0.1ml
EUR 518.4
Description: A polyclonal antibody for PKN1 (pThr774) from Human. The antibody is produced in rabbit after immunization with Human A phospho-specific peptide corresponding to residues surrounding Thr774 of human PKN1 (AA771-777). The Antibody is tested and validated for WB, AM assays with the following recommended dilutions: WB (1:250). This PKN1 (pThr774) antibody is conjugated to Dylight 488.

Antibody for Human PKN1 (pThr774)
SPC-1065D-DY594 0.1ml
EUR 523.2
Description: A polyclonal antibody for PKN1 (pThr774) from Human. The antibody is produced in rabbit after immunization with Human A phospho-specific peptide corresponding to residues surrounding Thr774 of human PKN1 (AA771-777). The Antibody is tested and validated for WB, AM assays with the following recommended dilutions: WB (1:250). This PKN1 (pThr774) antibody is conjugated to Dylight 594.

Antibody for Human PKN1 (pThr774)
SPC-1065D-DY633 0.1ml
EUR 511.2
Description: A polyclonal antibody for PKN1 (pThr774) from Human. The antibody is produced in rabbit after immunization with Human A phospho-specific peptide corresponding to residues surrounding Thr774 of human PKN1 (AA771-777). The Antibody is tested and validated for WB, AM assays with the following recommended dilutions: WB (1:250). This PKN1 (pThr774) antibody is conjugated to Dylight 633.

Antibody for Human PKN1 (pThr774)
SPC-1065D-FITC 0.1ml
EUR 470.4
Description: A polyclonal antibody for PKN1 (pThr774) from Human. The antibody is produced in rabbit after immunization with Human A phospho-specific peptide corresponding to residues surrounding Thr774 of human PKN1 (AA771-777). The Antibody is tested and validated for WB, AM assays with the following recommended dilutions: WB (1:250). This PKN1 (pThr774) antibody is conjugated to FITC.

Antibody for Human PKN1 (pThr774)
SPC-1065D-HRP 0.1ml
EUR 465.6
Description: A polyclonal antibody for PKN1 (pThr774) from Human. The antibody is produced in rabbit after immunization with Human A phospho-specific peptide corresponding to residues surrounding Thr774 of human PKN1 (AA771-777). The Antibody is tested and validated for WB, AM assays with the following recommended dilutions: WB (1:250). This PKN1 (pThr774) antibody is conjugated to HRP.

Antibody for Human PKN1 (pThr774)
SPC-1065D-P594 0.1ml
EUR 488.4
Description: A polyclonal antibody for PKN1 (pThr774) from Human. The antibody is produced in rabbit after immunization with Human A phospho-specific peptide corresponding to residues surrounding Thr774 of human PKN1 (AA771-777). The Antibody is tested and validated for WB, AM assays with the following recommended dilutions: WB (1:250). This PKN1 (pThr774) antibody is conjugated to PE/ATTO 594.

Antibody for Human PKN1 (pThr774)
SPC-1065D-PCP 0.1ml
EUR 478.8
Description: A polyclonal antibody for PKN1 (pThr774) from Human. The antibody is produced in rabbit after immunization with Human A phospho-specific peptide corresponding to residues surrounding Thr774 of human PKN1 (AA771-777). The Antibody is tested and validated for WB, AM assays with the following recommended dilutions: WB (1:250). This PKN1 (pThr774) antibody is conjugated to PerCP.

Antibody for Human PKN1 (pThr774)
SPC-1065D-RPE 0.1ml
EUR 476.4
Description: A polyclonal antibody for PKN1 (pThr774) from Human. The antibody is produced in rabbit after immunization with Human A phospho-specific peptide corresponding to residues surrounding Thr774 of human PKN1 (AA771-777). The Antibody is tested and validated for WB, AM assays with the following recommended dilutions: WB (1:250). This PKN1 (pThr774) antibody is conjugated to RPE .

Antibody for Human PKN1 (pThr774)
SPC-1065D-STR 0.1ml
EUR 477.6
Description: A polyclonal antibody for PKN1 (pThr774) from Human. The antibody is produced in rabbit after immunization with Human A phospho-specific peptide corresponding to residues surrounding Thr774 of human PKN1 (AA771-777). The Antibody is tested and validated for WB, AM assays with the following recommended dilutions: WB (1:250). This PKN1 (pThr774) antibody is conjugated to Streptavidin.

Human PKN1 shRNA Plasmid
20-abx953755
  • EUR 961.20
  • EUR 1345.20
  • 150 µg
  • 300 µg

Mouse PKN1 shRNA Plasmid
20-abx983453
  • EUR 961.20
  • EUR 1345.20
  • 150 µg
  • 300 µg

Rat PKN1 shRNA Plasmid
20-abx985442
  • EUR 961.20
  • EUR 1345.20
  • 150 µg
  • 300 µg

Porcine PKN1 ELISA Kit
EPP0125 96Tests
EUR 625.2

Rabbit PKN1 ELISA Kit
ERTP0125 96Tests
EUR 625.2

Rat PKN1 ELISA Kit
ERP0125 96Tests
EUR 625.2

Goat PKN1 ELISA Kit
EGTP0125 96Tests
EUR 625.2

Mouse PKN1 ELISA Kit
EMP0125 96Tests
EUR 625.2

Human PKN1 ELISA Kit
EHP0125 96Tests
EUR 625.2

PKN1 ELISA KIT|Human
EF005461 96 Tests
EUR 826.8

Bovine PKN1 ELISA Kit
EBP0125 96Tests
EUR 625.2

Canine PKN1 ELISA Kit
ECP0125 96Tests
EUR 625.2

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